Limits...
Reprint of 'Model of unidirectional block formation leading to reentrant ventricular tachycardia in the infarct border zone of postinfarction canine hearts'.

Ciaccio EJ, Coromilas J, Ashikaga H, Cervantes DO, Wit AL, Peters NS, McVeigh ER, Garan H - Comput. Biol. Med. (2015)

Bottom Line: A quantitative model was developed to describe how thin-to-thick changes in the border zone result in critically convex wavefront curvature leading to conduction block, which is dependent upon coupling interval.The double-loop reentrant circuit pattern is a consequence of wavefront bifurcation around this UBL followed by coalescence, and then impulse propagation through the isthmus.The wavefront is blocked from propagating laterally away from the isthmus by sharp increases in border zone thickness, which results in critically convex wavefront curvature at VT cycle lengths.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, United States. Electronic address: ciaccio@columbia.edu.

No MeSH data available.


Related in: MedlinePlus

Comparison of the locations of the premature stimulus site (circle), the unidirectional block line forming from this site (thinner curved gray line), and functional block (thick curved black lines) during double-loop reentrant ventricular tachycardia, for all 12 experiments of the study. In each panel, the arrow denotes the direction of propagation through the isthmus during reentrant ventricular tachycardia. In panel 9, very slow conduction rather than actual block is denoted by a dotted line.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4593299&req=5

f0035: Comparison of the locations of the premature stimulus site (circle), the unidirectional block line forming from this site (thinner curved gray line), and functional block (thick curved black lines) during double-loop reentrant ventricular tachycardia, for all 12 experiments of the study. In each panel, the arrow denotes the direction of propagation through the isthmus during reentrant ventricular tachycardia. In panel 9, very slow conduction rather than actual block is denoted by a dotted line.

Mentions: In Fig. 7 is depicted the results of activation mapping for all 12 postinfarction canine experiments, which are numbered. A marker depicting 10 mm in length is shown at lower right in the figure, and it applies to all 12 panels, which are drawn to scale. The LAD side of the grid is at top for all 12 panels. Functional lines of conduction block during reentry are illustrated as thick black lines. The UBL of premature stimulation resulting in reentry is delineated as a thinner gray line. The stimulus site is noted by a circle, and the direction of propagation leading to breakthrough at onset of the first reentry cycle is delineated as a black arrow. The stimulus site is approximately in the direction of this arrow, in proximity to the isthmus exit location. The UBL forms at the isthmus end that is furthest from the stimulus site, which becomes the isthmus entrance during reentry. The lateral UBL edges approximately coincide with the lateral isthmus boundaries during reentry. Overall, the error was 4.8±5.7 mm (measurement e, Fig. 3). The relatively large standard deviation occurred because in six experiments the UBL edges and the lateral isthmus boundaries overlapped (error=0) while in a few experiments there was some misalignment.


Reprint of 'Model of unidirectional block formation leading to reentrant ventricular tachycardia in the infarct border zone of postinfarction canine hearts'.

Ciaccio EJ, Coromilas J, Ashikaga H, Cervantes DO, Wit AL, Peters NS, McVeigh ER, Garan H - Comput. Biol. Med. (2015)

Comparison of the locations of the premature stimulus site (circle), the unidirectional block line forming from this site (thinner curved gray line), and functional block (thick curved black lines) during double-loop reentrant ventricular tachycardia, for all 12 experiments of the study. In each panel, the arrow denotes the direction of propagation through the isthmus during reentrant ventricular tachycardia. In panel 9, very slow conduction rather than actual block is denoted by a dotted line.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4593299&req=5

f0035: Comparison of the locations of the premature stimulus site (circle), the unidirectional block line forming from this site (thinner curved gray line), and functional block (thick curved black lines) during double-loop reentrant ventricular tachycardia, for all 12 experiments of the study. In each panel, the arrow denotes the direction of propagation through the isthmus during reentrant ventricular tachycardia. In panel 9, very slow conduction rather than actual block is denoted by a dotted line.
Mentions: In Fig. 7 is depicted the results of activation mapping for all 12 postinfarction canine experiments, which are numbered. A marker depicting 10 mm in length is shown at lower right in the figure, and it applies to all 12 panels, which are drawn to scale. The LAD side of the grid is at top for all 12 panels. Functional lines of conduction block during reentry are illustrated as thick black lines. The UBL of premature stimulation resulting in reentry is delineated as a thinner gray line. The stimulus site is noted by a circle, and the direction of propagation leading to breakthrough at onset of the first reentry cycle is delineated as a black arrow. The stimulus site is approximately in the direction of this arrow, in proximity to the isthmus exit location. The UBL forms at the isthmus end that is furthest from the stimulus site, which becomes the isthmus entrance during reentry. The lateral UBL edges approximately coincide with the lateral isthmus boundaries during reentry. Overall, the error was 4.8±5.7 mm (measurement e, Fig. 3). The relatively large standard deviation occurred because in six experiments the UBL edges and the lateral isthmus boundaries overlapped (error=0) while in a few experiments there was some misalignment.

Bottom Line: A quantitative model was developed to describe how thin-to-thick changes in the border zone result in critically convex wavefront curvature leading to conduction block, which is dependent upon coupling interval.The double-loop reentrant circuit pattern is a consequence of wavefront bifurcation around this UBL followed by coalescence, and then impulse propagation through the isthmus.The wavefront is blocked from propagating laterally away from the isthmus by sharp increases in border zone thickness, which results in critically convex wavefront curvature at VT cycle lengths.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, United States. Electronic address: ciaccio@columbia.edu.

No MeSH data available.


Related in: MedlinePlus