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Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis.

Tian X, Xu G - BMJ Open (2015)

Bottom Line: A significant association between MALAT1 overexpression and poor overall survival (OS) (HR=1.95; 95% CI 1.57 to 2.41) was observed.A similar effect was also seen in different regions.Furthermore, the overexpression of MALAT1 was associated with disease-free, recurrence-free and progression-free survivals.

View Article: PubMed Central - PubMed

Affiliation: Center Laboratory, Jinshan Hospital, Fudan University, Shanghai, China.

No MeSH data available.


Related in: MedlinePlus

Sensitivity analysis of the effect of the individual study on the pooled HRs for the correlation between MALAT1 expression and overall survival (OS) in patients with cancer by univariate and multivariate analyses. (A) Sensitivity analysis of the effect of the individual study on the pooled HRs of OS in the different types of cancer with MALAT1 overexpression. (B) Sensitivity analysis of the effect of the individual study on the independent role of MALAT1 on OS in the different types of cancer by univariate analysis. (C) Sensitivity analysis of the effect of the individual study on the independent role of MALAT-1 on OS in the different types of cancer by multivariate analysis.
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BMJOPEN2015008653F4: Sensitivity analysis of the effect of the individual study on the pooled HRs for the correlation between MALAT1 expression and overall survival (OS) in patients with cancer by univariate and multivariate analyses. (A) Sensitivity analysis of the effect of the individual study on the pooled HRs of OS in the different types of cancer with MALAT1 overexpression. (B) Sensitivity analysis of the effect of the individual study on the independent role of MALAT1 on OS in the different types of cancer by univariate analysis. (C) Sensitivity analysis of the effect of the individual study on the independent role of MALAT-1 on OS in the different types of cancer by multivariate analysis.

Mentions: A meta-regression was applied to quantify the heterogeneity among the covariates, including region, sample size, the type of cancer and paper quality (table 2). We found that there was no specific factor accounting for the interstudy heterogeneity which was consistent with the results of the subgroup analysis. Moreover, the sensitivity analyses showed that the pooled HRs of OS were reliable (figure 4). The exclusion of any individual study did not change the significance of the HRs. The results of sensitivity analyses were similar between those included data and excluded data obtained from Kaplan–Meier curves (see online supplementary information).


Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis.

Tian X, Xu G - BMJ Open (2015)

Sensitivity analysis of the effect of the individual study on the pooled HRs for the correlation between MALAT1 expression and overall survival (OS) in patients with cancer by univariate and multivariate analyses. (A) Sensitivity analysis of the effect of the individual study on the pooled HRs of OS in the different types of cancer with MALAT1 overexpression. (B) Sensitivity analysis of the effect of the individual study on the independent role of MALAT1 on OS in the different types of cancer by univariate analysis. (C) Sensitivity analysis of the effect of the individual study on the independent role of MALAT-1 on OS in the different types of cancer by multivariate analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4593150&req=5

BMJOPEN2015008653F4: Sensitivity analysis of the effect of the individual study on the pooled HRs for the correlation between MALAT1 expression and overall survival (OS) in patients with cancer by univariate and multivariate analyses. (A) Sensitivity analysis of the effect of the individual study on the pooled HRs of OS in the different types of cancer with MALAT1 overexpression. (B) Sensitivity analysis of the effect of the individual study on the independent role of MALAT1 on OS in the different types of cancer by univariate analysis. (C) Sensitivity analysis of the effect of the individual study on the independent role of MALAT-1 on OS in the different types of cancer by multivariate analysis.
Mentions: A meta-regression was applied to quantify the heterogeneity among the covariates, including region, sample size, the type of cancer and paper quality (table 2). We found that there was no specific factor accounting for the interstudy heterogeneity which was consistent with the results of the subgroup analysis. Moreover, the sensitivity analyses showed that the pooled HRs of OS were reliable (figure 4). The exclusion of any individual study did not change the significance of the HRs. The results of sensitivity analyses were similar between those included data and excluded data obtained from Kaplan–Meier curves (see online supplementary information).

Bottom Line: A significant association between MALAT1 overexpression and poor overall survival (OS) (HR=1.95; 95% CI 1.57 to 2.41) was observed.A similar effect was also seen in different regions.Furthermore, the overexpression of MALAT1 was associated with disease-free, recurrence-free and progression-free survivals.

View Article: PubMed Central - PubMed

Affiliation: Center Laboratory, Jinshan Hospital, Fudan University, Shanghai, China.

No MeSH data available.


Related in: MedlinePlus