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Trends in global clinical trial registration: an analysis of numbers of registered clinical trials in different parts of the world from 2004 to 2013.

Viergever RF, Li K - BMJ Open (2015)

Bottom Line: In India and Japan, two countries with marked but more gradual increases, these increases only happened after several local measures were implemented that encouraged and enforced registration.However, these improvements have not taken place equally in all parts of the world.Achieving compliance with registration requires a coalescence of global and local measures, and remains a key challenge in many countries.

View Article: PubMed Central - PubMed

Affiliation: Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

No MeSH data available.


Related in: MedlinePlus

Annual numbers of clinical trials on the International Clinical Trials Registry Platform (ICTRP) registered for recruitment in country income groups (A) and geographical regions (B) from 1998 to 2013. Legend is ordered by numbers of registered trials in 2013. Numbers for further regional disaggregation for the year 2013 do not add up to regional totals because trials were regularly registered for recruitment in multiple regions. Information on countries or regions of recruitment was available for 179 724 interventional trials. A total of 113 trials only specified a region of recruitment (eg, Asia) and not a country of recruitment, and were not included for the income group analysis.
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BMJOPEN2015008932F3: Annual numbers of clinical trials on the International Clinical Trials Registry Platform (ICTRP) registered for recruitment in country income groups (A) and geographical regions (B) from 1998 to 2013. Legend is ordered by numbers of registered trials in 2013. Numbers for further regional disaggregation for the year 2013 do not add up to regional totals because trials were regularly registered for recruitment in multiple regions. Information on countries or regions of recruitment was available for 179 724 interventional trials. A total of 113 trials only specified a region of recruitment (eg, Asia) and not a country of recruitment, and were not included for the income group analysis.

Mentions: Information on trials’ country(ies) or region(s) of recruitment was available for 179 724 trials. Figure 3 provides an overview of how many trials were registered every year for participant recruitment in different parts of the world. From 1999 to 2004, the figure shows small increases in the annual numbers of trials registered for recruitment in Northern America and in Europe, corresponding to increases in numbers of trials registered at ClinicalTrials.gov, the International Standard Randomised Controlled Trial Number Register (ISRCTN), and the EU Clinical Trials Register (EU-CTR) (see figure 2). In 2005, the year that trial registration became a prerequisite for publication according to ICMJE guidelines, annual numbers of registered trials showed marked increases in all regions, particularly in Northern America and in Europe. In other regions, particularly Asia, the annual number of registered clinical trials increased more gradually and continued to increase up to 2013. Numbers of registered clinical trials were lowest in Africa, and in Latin America and the Caribbean. Finally, registration appears to show a second peak in Northern America in 2008.


Trends in global clinical trial registration: an analysis of numbers of registered clinical trials in different parts of the world from 2004 to 2013.

Viergever RF, Li K - BMJ Open (2015)

Annual numbers of clinical trials on the International Clinical Trials Registry Platform (ICTRP) registered for recruitment in country income groups (A) and geographical regions (B) from 1998 to 2013. Legend is ordered by numbers of registered trials in 2013. Numbers for further regional disaggregation for the year 2013 do not add up to regional totals because trials were regularly registered for recruitment in multiple regions. Information on countries or regions of recruitment was available for 179 724 interventional trials. A total of 113 trials only specified a region of recruitment (eg, Asia) and not a country of recruitment, and were not included for the income group analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4593134&req=5

BMJOPEN2015008932F3: Annual numbers of clinical trials on the International Clinical Trials Registry Platform (ICTRP) registered for recruitment in country income groups (A) and geographical regions (B) from 1998 to 2013. Legend is ordered by numbers of registered trials in 2013. Numbers for further regional disaggregation for the year 2013 do not add up to regional totals because trials were regularly registered for recruitment in multiple regions. Information on countries or regions of recruitment was available for 179 724 interventional trials. A total of 113 trials only specified a region of recruitment (eg, Asia) and not a country of recruitment, and were not included for the income group analysis.
Mentions: Information on trials’ country(ies) or region(s) of recruitment was available for 179 724 trials. Figure 3 provides an overview of how many trials were registered every year for participant recruitment in different parts of the world. From 1999 to 2004, the figure shows small increases in the annual numbers of trials registered for recruitment in Northern America and in Europe, corresponding to increases in numbers of trials registered at ClinicalTrials.gov, the International Standard Randomised Controlled Trial Number Register (ISRCTN), and the EU Clinical Trials Register (EU-CTR) (see figure 2). In 2005, the year that trial registration became a prerequisite for publication according to ICMJE guidelines, annual numbers of registered trials showed marked increases in all regions, particularly in Northern America and in Europe. In other regions, particularly Asia, the annual number of registered clinical trials increased more gradually and continued to increase up to 2013. Numbers of registered clinical trials were lowest in Africa, and in Latin America and the Caribbean. Finally, registration appears to show a second peak in Northern America in 2008.

Bottom Line: In India and Japan, two countries with marked but more gradual increases, these increases only happened after several local measures were implemented that encouraged and enforced registration.However, these improvements have not taken place equally in all parts of the world.Achieving compliance with registration requires a coalescence of global and local measures, and remains a key challenge in many countries.

View Article: PubMed Central - PubMed

Affiliation: Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

No MeSH data available.


Related in: MedlinePlus