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Curcuma aromatica Water Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status.

Jeon WY, Lee MY, Shin IS, Jin SE, Ha H - Evid Based Complement Alternat Med (2015)

Bottom Line: To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach.CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach.These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status.

View Article: PubMed Central - PubMed

Affiliation: K-Herb Research Center, Korea Institute of Oriental Medicine, 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea.

ABSTRACT
Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW) in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach. CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach. CAW reduced the increase in lipid peroxidation associated with ethanol-induced gastritis (250 and 500 mg/kg, p < 0.01, resp.) and increased mucosal GSH content (500 mg/kg, p < 0.01) and the activity of catalase (250 and 500 mg/kg, p < 0.01, resp.). CAW increased the production of prostaglandin E2. These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status. We suggest that CAW could be developed for the treatment of gastritis induced by alcohol.

No MeSH data available.


Related in: MedlinePlus

Effects of CAW on gastric MDA concentration (a) and GSH contents (b) in rats with absolute ethanol-induced gastritis. Each bar represents the mean ± SD of five rats. Control, normal control group; EtOH, absolute ethanol treatment group; cimetidine, ethanol + cimetidine (100 mg/kg); CAW-250, ethanol + CAW (250 mg/kg); CAW-500, ethanol + CAW (500 mg/kg). ##p < 0.01 compared with the control group and ∗p < 0.05 and ∗∗p < 0.01 compared with rats in the EtOH group.
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fig1: Effects of CAW on gastric MDA concentration (a) and GSH contents (b) in rats with absolute ethanol-induced gastritis. Each bar represents the mean ± SD of five rats. Control, normal control group; EtOH, absolute ethanol treatment group; cimetidine, ethanol + cimetidine (100 mg/kg); CAW-250, ethanol + CAW (250 mg/kg); CAW-500, ethanol + CAW (500 mg/kg). ##p < 0.01 compared with the control group and ∗p < 0.05 and ∗∗p < 0.01 compared with rats in the EtOH group.

Mentions: The concentration of MDA, an end product of lipid peroxidation, was greater in the stomach of rats in the EtOH group (130.75 ± 17.25 nmol/mg protein, p < 0.01) than in the stomach of control group (72.05 ± 8.39 nmol/mg protein) (Figure 1(a)). The MDA level in rats in the CAW-treated group was significantly reduced at 250 (76.60 ± 9.33 nmol/mg protein, p < 0.01) and 500 (62.11 ± 19.01 nmol/mg protein, p < 0.01) mg/kg compared with rats in the EtOH group. A significant reduction of MDA was observed in rats in the cimetidine-treated group (63.42 ± 14.11 nmol/mg protein, p < 0.01) compared with rat in the EtOH group.


Curcuma aromatica Water Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status.

Jeon WY, Lee MY, Shin IS, Jin SE, Ha H - Evid Based Complement Alternat Med (2015)

Effects of CAW on gastric MDA concentration (a) and GSH contents (b) in rats with absolute ethanol-induced gastritis. Each bar represents the mean ± SD of five rats. Control, normal control group; EtOH, absolute ethanol treatment group; cimetidine, ethanol + cimetidine (100 mg/kg); CAW-250, ethanol + CAW (250 mg/kg); CAW-500, ethanol + CAW (500 mg/kg). ##p < 0.01 compared with the control group and ∗p < 0.05 and ∗∗p < 0.01 compared with rats in the EtOH group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4592911&req=5

fig1: Effects of CAW on gastric MDA concentration (a) and GSH contents (b) in rats with absolute ethanol-induced gastritis. Each bar represents the mean ± SD of five rats. Control, normal control group; EtOH, absolute ethanol treatment group; cimetidine, ethanol + cimetidine (100 mg/kg); CAW-250, ethanol + CAW (250 mg/kg); CAW-500, ethanol + CAW (500 mg/kg). ##p < 0.01 compared with the control group and ∗p < 0.05 and ∗∗p < 0.01 compared with rats in the EtOH group.
Mentions: The concentration of MDA, an end product of lipid peroxidation, was greater in the stomach of rats in the EtOH group (130.75 ± 17.25 nmol/mg protein, p < 0.01) than in the stomach of control group (72.05 ± 8.39 nmol/mg protein) (Figure 1(a)). The MDA level in rats in the CAW-treated group was significantly reduced at 250 (76.60 ± 9.33 nmol/mg protein, p < 0.01) and 500 (62.11 ± 19.01 nmol/mg protein, p < 0.01) mg/kg compared with rats in the EtOH group. A significant reduction of MDA was observed in rats in the cimetidine-treated group (63.42 ± 14.11 nmol/mg protein, p < 0.01) compared with rat in the EtOH group.

Bottom Line: To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach.CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach.These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status.

View Article: PubMed Central - PubMed

Affiliation: K-Herb Research Center, Korea Institute of Oriental Medicine, 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea.

ABSTRACT
Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW) in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach. CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach. CAW reduced the increase in lipid peroxidation associated with ethanol-induced gastritis (250 and 500 mg/kg, p < 0.01, resp.) and increased mucosal GSH content (500 mg/kg, p < 0.01) and the activity of catalase (250 and 500 mg/kg, p < 0.01, resp.). CAW increased the production of prostaglandin E2. These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status. We suggest that CAW could be developed for the treatment of gastritis induced by alcohol.

No MeSH data available.


Related in: MedlinePlus