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Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review.

Ahmadi A, Zorofchian Moghadamtousi S, Abubakar S, Zandi K - Biomed Res Int (2015)

Bottom Line: Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research.Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan.This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

ABSTRACT
From food to fertilizer, algal derived products are largely employed in assorted industries, including agricultural, biomedical, food, and pharmaceutical industries. Among different chemical compositions isolated from algae, polysaccharides are the most well-established compounds, which were subjected to a variety of studies due to extensive bioactivities. Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research. Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan. In addition, different mechanisms of action have been reported for these polysaccharides, such as inhibiting the binding or internalization of virus into the host cells or suppressing DNA replication and protein synthesis. This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

No MeSH data available.


Related in: MedlinePlus

Chemical structures of two different backbones for fucoidan. R groups demonstrate potential places for attachment of carbohydrate (α-L-fucopyranose and α-D-glucuronic acid) and noncarbohydrate (sulfate and acetyl groups) substituents.
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fig5: Chemical structures of two different backbones for fucoidan. R groups demonstrate potential places for attachment of carbohydrate (α-L-fucopyranose and α-D-glucuronic acid) and noncarbohydrate (sulfate and acetyl groups) substituents.

Mentions: Fucoidan is a term used to define a polysaccharide based mainly on sulfated L-fucose and less than 10% on other monosaccharides. The term sulfated fucan can be used to define heterofucans containing sulfated fucose and neutral sugars. However, fucans and fucoidans are often used interchangeably. Fucoidan has a high proportion of fucose in the extracellular matrix of several brown algae such as mozuku, komby, limu moui, bladderwrack, wakame, hijiki, and sea cucumber. The main skeleton of fucoidans involves a-1,3-linked sulfated L-fucose, a repeating sequence of alternating a-(1-3)- with the possible a-(1-4)-glycosidic bonds. The chemical structure and composition of fucoidans are considerably diverse, depending highly on the isolated species, which usually are sulfated and acetylated and may also hold uronic acid (Figure 5) [70–72].


Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review.

Ahmadi A, Zorofchian Moghadamtousi S, Abubakar S, Zandi K - Biomed Res Int (2015)

Chemical structures of two different backbones for fucoidan. R groups demonstrate potential places for attachment of carbohydrate (α-L-fucopyranose and α-D-glucuronic acid) and noncarbohydrate (sulfate and acetyl groups) substituents.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592888&req=5

fig5: Chemical structures of two different backbones for fucoidan. R groups demonstrate potential places for attachment of carbohydrate (α-L-fucopyranose and α-D-glucuronic acid) and noncarbohydrate (sulfate and acetyl groups) substituents.
Mentions: Fucoidan is a term used to define a polysaccharide based mainly on sulfated L-fucose and less than 10% on other monosaccharides. The term sulfated fucan can be used to define heterofucans containing sulfated fucose and neutral sugars. However, fucans and fucoidans are often used interchangeably. Fucoidan has a high proportion of fucose in the extracellular matrix of several brown algae such as mozuku, komby, limu moui, bladderwrack, wakame, hijiki, and sea cucumber. The main skeleton of fucoidans involves a-1,3-linked sulfated L-fucose, a repeating sequence of alternating a-(1-3)- with the possible a-(1-4)-glycosidic bonds. The chemical structure and composition of fucoidans are considerably diverse, depending highly on the isolated species, which usually are sulfated and acetylated and may also hold uronic acid (Figure 5) [70–72].

Bottom Line: Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research.Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan.This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

ABSTRACT
From food to fertilizer, algal derived products are largely employed in assorted industries, including agricultural, biomedical, food, and pharmaceutical industries. Among different chemical compositions isolated from algae, polysaccharides are the most well-established compounds, which were subjected to a variety of studies due to extensive bioactivities. Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research. Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan. In addition, different mechanisms of action have been reported for these polysaccharides, such as inhibiting the binding or internalization of virus into the host cells or suppressing DNA replication and protein synthesis. This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

No MeSH data available.


Related in: MedlinePlus