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Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review.

Ahmadi A, Zorofchian Moghadamtousi S, Abubakar S, Zandi K - Biomed Res Int (2015)

Bottom Line: Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research.Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan.This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

ABSTRACT
From food to fertilizer, algal derived products are largely employed in assorted industries, including agricultural, biomedical, food, and pharmaceutical industries. Among different chemical compositions isolated from algae, polysaccharides are the most well-established compounds, which were subjected to a variety of studies due to extensive bioactivities. Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research. Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan. In addition, different mechanisms of action have been reported for these polysaccharides, such as inhibiting the binding or internalization of virus into the host cells or suppressing DNA replication and protein synthesis. This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

No MeSH data available.


Related in: MedlinePlus

Chemical structure of alginate polysaccharide (GM blocks).
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fig3: Chemical structure of alginate polysaccharide (GM blocks).

Mentions: Alginates are the principle cell wall acidic polysaccharides widely distributed in brown algae (Phaeophyceae) including Laminaria hyperborea, Laminaria digitata, Laminaria japonica, Ascophyllum nodosum, and Macrocystis pyrifera. They are mostly extracted from bubble Zosteraceae, kelp, macro algae, and marjoram algae, respectively. Alginates are linear anionic polysaccharides, composed of a main backbone of poly-D-glucuronic acid (G blocks) and poly-D-mannuronic acid (M blocks), together with D-guluronic acid and D-mannuronic acid (GM blocks) usually alternating (Figure 3) [54, 55]. Alginates have found numerous applications in biomedical science and engineering and have been particularly attractive for their antiviral activities.


Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review.

Ahmadi A, Zorofchian Moghadamtousi S, Abubakar S, Zandi K - Biomed Res Int (2015)

Chemical structure of alginate polysaccharide (GM blocks).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592888&req=5

fig3: Chemical structure of alginate polysaccharide (GM blocks).
Mentions: Alginates are the principle cell wall acidic polysaccharides widely distributed in brown algae (Phaeophyceae) including Laminaria hyperborea, Laminaria digitata, Laminaria japonica, Ascophyllum nodosum, and Macrocystis pyrifera. They are mostly extracted from bubble Zosteraceae, kelp, macro algae, and marjoram algae, respectively. Alginates are linear anionic polysaccharides, composed of a main backbone of poly-D-glucuronic acid (G blocks) and poly-D-mannuronic acid (M blocks), together with D-guluronic acid and D-mannuronic acid (GM blocks) usually alternating (Figure 3) [54, 55]. Alginates have found numerous applications in biomedical science and engineering and have been particularly attractive for their antiviral activities.

Bottom Line: Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research.Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan.This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

ABSTRACT
From food to fertilizer, algal derived products are largely employed in assorted industries, including agricultural, biomedical, food, and pharmaceutical industries. Among different chemical compositions isolated from algae, polysaccharides are the most well-established compounds, which were subjected to a variety of studies due to extensive bioactivities. Over the past few decades, the promising results for antiviral potential of algae-derived polysaccharides have advocated them as inordinate candidates for pharmaceutical research. Numerous studies have isolated various algal polysaccharides possessing antiviral activities, including carrageenan, alginate, fucan, laminaran, and naviculan. In addition, different mechanisms of action have been reported for these polysaccharides, such as inhibiting the binding or internalization of virus into the host cells or suppressing DNA replication and protein synthesis. This review strives for compiling previous antiviral studies of algae-derived polysaccharides and their mechanism of action towards their development as natural antiviral agents for future investigations.

No MeSH data available.


Related in: MedlinePlus