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IRAK4 gene polymorphism and odontogenic maxillary sinusitis.

Pereira IG, Vaz P, Almeida RF, Braga AC, Felino A - Clin Oral Investig (2015)

Bottom Line: The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %].This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.The area under the ROC curve found, AUC = 0.91, revealed that the model correctly predicts the outcome in 91.1% of cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Surgery, Faculty of Dentistry, Oporto University, Rua Dr. Manuel Pereira da Silva, 4200 393, Porto, Portugal. inesguerrapereira@gmail.com.

ABSTRACT

Objectives: This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin.

Materials and methods: The study population included 153 Portuguese Caucasians that were selected from a database of 504 retrospectively analysed computed tomography (CT) scans. A genetic test was performed, and a model was created through logistic analysis and regression coefficients. The statistical methodologies included were the independent Chi test, Fisher's exact test, binary logistic regression and the receiver operating characteristic (ROC) curve.

Results: The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed. This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.

Conclusions: The constructed model should be considered an initial clinical tool. The area under the ROC curve found, AUC = 0.91, revealed that the model correctly predicts the outcome in 91.1% of cases.

Clinical relevance: The clinical relevance of this study lies in trying to achieve a potential tool (a model) that may assist the clinician in the implementation of suitable dental treatment plans in complex cases, with probable involvement of the maxillary sinus.

No MeSH data available.


Related in: MedlinePlus

Illustration of the statistical association between the presence of IRAK4 gene polymorphism (positive genetic test) and the presence of the mucosal thickening of maxillary sinus on computed tomography image
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Fig2: Illustration of the statistical association between the presence of IRAK4 gene polymorphism (positive genetic test) and the presence of the mucosal thickening of maxillary sinus on computed tomography image

Mentions: The Fisher exact test (p = 0.030 < 0.05) showed statistically significant association between the presence of the IRAK4 gene polymorphism and the mucosal thickening on CT imaging (Fig. 2).Fig. 2


IRAK4 gene polymorphism and odontogenic maxillary sinusitis.

Pereira IG, Vaz P, Almeida RF, Braga AC, Felino A - Clin Oral Investig (2015)

Illustration of the statistical association between the presence of IRAK4 gene polymorphism (positive genetic test) and the presence of the mucosal thickening of maxillary sinus on computed tomography image
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4592703&req=5

Fig2: Illustration of the statistical association between the presence of IRAK4 gene polymorphism (positive genetic test) and the presence of the mucosal thickening of maxillary sinus on computed tomography image
Mentions: The Fisher exact test (p = 0.030 < 0.05) showed statistically significant association between the presence of the IRAK4 gene polymorphism and the mucosal thickening on CT imaging (Fig. 2).Fig. 2

Bottom Line: The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %].This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.The area under the ROC curve found, AUC = 0.91, revealed that the model correctly predicts the outcome in 91.1% of cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Surgery, Faculty of Dentistry, Oporto University, Rua Dr. Manuel Pereira da Silva, 4200 393, Porto, Portugal. inesguerrapereira@gmail.com.

ABSTRACT

Objectives: This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin.

Materials and methods: The study population included 153 Portuguese Caucasians that were selected from a database of 504 retrospectively analysed computed tomography (CT) scans. A genetic test was performed, and a model was created through logistic analysis and regression coefficients. The statistical methodologies included were the independent Chi test, Fisher's exact test, binary logistic regression and the receiver operating characteristic (ROC) curve.

Results: The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95%) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed. This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.

Conclusions: The constructed model should be considered an initial clinical tool. The area under the ROC curve found, AUC = 0.91, revealed that the model correctly predicts the outcome in 91.1% of cases.

Clinical relevance: The clinical relevance of this study lies in trying to achieve a potential tool (a model) that may assist the clinician in the implementation of suitable dental treatment plans in complex cases, with probable involvement of the maxillary sinus.

No MeSH data available.


Related in: MedlinePlus