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Expression of Fascin-1 on human lung cancer and paracarcinoma tissue and its relation to clinicopathological characteristics in patients with lung cancer.

Zhao W, Gao J, Wu J, Liu QH, Wang ZG, Li HL, Xing LH - Onco Targets Ther (2015)

Bottom Line: This study set the expression of Fascin-1 in vascular endothelial cells as the positive control, and used phosphate buffered saline (replacing the primary antibodies) as negative control.Differences in Fascin-1 expression between different age groups, clinical stages, and lymph node metastases were statistically significant (P<0.05), while differences in Fascin-1 expression between sexes, tumor stages, and pathological types demonstrated no statistical significance (P>0.05).In lung cancer, Fascin-1 expression was closely related to tumor invasion and metastasis, and the difference in expression of Fascin-1 had a significant effect on the survival time of the lung cancer patients.

View Article: PubMed Central - PubMed

Affiliation: The Third Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.

ABSTRACT

Background: Lung cancer poses a severe threat to human life. Biomarkers of cancers are helpful in the diagnosis and treatment of patients with cancers. Biomarkers of lung cancers are rare, and thus deserve further research.

Objective: The objective of the present study was to explore the expression of Fascin-1 in human lung cancer and paracarcinoma tissue, its correlation with clinicopathological characteristics in patients with lung cancer, and study the possible relationship between Fascin-1 expression and clinical-biological behavior of lung cancer.

Method: This study used the MaxVision two-step immunohistochemical detection method to detect Fascin-1 expression in 84 of lung cancer and paracarcinoma tissues. This study set the expression of Fascin-1 in vascular endothelial cells as the positive control, and used phosphate buffered saline (replacing the primary antibodies) as negative control.

Result: Of all the 84 lung cancer tissues and paracarcinoma tissues, positive expression of the Fascin-1 protein were detected in 78 cases (92.9%) and 27 cases (32.1%), respectively, and the difference was statistically significant (P<0.05). Differences in Fascin-1 expression between different age groups, clinical stages, and lymph node metastases were statistically significant (P<0.05), while differences in Fascin-1 expression between sexes, tumor stages, and pathological types demonstrated no statistical significance (P>0.05). The survival times of the patients with different Fascin-1 protein-positive expressions in lung cancer tissues were statistically significant (P>0.05), while the survival times of the patients with different Fascin-1 protein-positive expressions in paracarcinoma tissues were not statistically significant (P>0.05).

Conclusion: In lung cancer, Fascin-1 expression was closely related to tumor invasion and metastasis, and the difference in expression of Fascin-1 had a significant effect on the survival time of the lung cancer patients. Therefore, Fascin-1 might be expected to serve as a possible potential biomarker of lung cancer.

No MeSH data available.


Related in: MedlinePlus

Overall survival stairs of patients with different Fascin-1 protein-positive expression in lung cancer tissues.
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f3-ott-8-2571: Overall survival stairs of patients with different Fascin-1 protein-positive expression in lung cancer tissues.

Mentions: In the follow-up of 40 patients, until the finalization of follow-up on March 2013, there were 21 deaths, and 19 survivors. The overall survival rate was 47.5%, and the survival time was 8–70 months. Then, this study analyzed Fascin-1 protein-positive expression in lung cancer tissues and patient survival time, the median survival time of different patients, and the differences in intensity of Fascin-1 protein-positive expression in lung cancer tissue in different patients. The results demonstrated that there were significant differences in expression of Fascin-1 in different patients with different survival time (P<0.05); in paracarcinoma tissues, the median survival time of different patients and the difference in intensity of Fascin-1 protein-positive expression was not significantly different (P>0.05), as shown in Table 2 and Figure 3. Multivariable Cox regression analysis also showed that Fascin-1 protein-positive expression intensity in lung cancer tissue was closely related to the survival time of the patients (hazard ratio =4.505, 95% CI =1.615–12.569, P=0.004).


Expression of Fascin-1 on human lung cancer and paracarcinoma tissue and its relation to clinicopathological characteristics in patients with lung cancer.

Zhao W, Gao J, Wu J, Liu QH, Wang ZG, Li HL, Xing LH - Onco Targets Ther (2015)

Overall survival stairs of patients with different Fascin-1 protein-positive expression in lung cancer tissues.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592059&req=5

f3-ott-8-2571: Overall survival stairs of patients with different Fascin-1 protein-positive expression in lung cancer tissues.
Mentions: In the follow-up of 40 patients, until the finalization of follow-up on March 2013, there were 21 deaths, and 19 survivors. The overall survival rate was 47.5%, and the survival time was 8–70 months. Then, this study analyzed Fascin-1 protein-positive expression in lung cancer tissues and patient survival time, the median survival time of different patients, and the differences in intensity of Fascin-1 protein-positive expression in lung cancer tissue in different patients. The results demonstrated that there were significant differences in expression of Fascin-1 in different patients with different survival time (P<0.05); in paracarcinoma tissues, the median survival time of different patients and the difference in intensity of Fascin-1 protein-positive expression was not significantly different (P>0.05), as shown in Table 2 and Figure 3. Multivariable Cox regression analysis also showed that Fascin-1 protein-positive expression intensity in lung cancer tissue was closely related to the survival time of the patients (hazard ratio =4.505, 95% CI =1.615–12.569, P=0.004).

Bottom Line: This study set the expression of Fascin-1 in vascular endothelial cells as the positive control, and used phosphate buffered saline (replacing the primary antibodies) as negative control.Differences in Fascin-1 expression between different age groups, clinical stages, and lymph node metastases were statistically significant (P<0.05), while differences in Fascin-1 expression between sexes, tumor stages, and pathological types demonstrated no statistical significance (P>0.05).In lung cancer, Fascin-1 expression was closely related to tumor invasion and metastasis, and the difference in expression of Fascin-1 had a significant effect on the survival time of the lung cancer patients.

View Article: PubMed Central - PubMed

Affiliation: The Third Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.

ABSTRACT

Background: Lung cancer poses a severe threat to human life. Biomarkers of cancers are helpful in the diagnosis and treatment of patients with cancers. Biomarkers of lung cancers are rare, and thus deserve further research.

Objective: The objective of the present study was to explore the expression of Fascin-1 in human lung cancer and paracarcinoma tissue, its correlation with clinicopathological characteristics in patients with lung cancer, and study the possible relationship between Fascin-1 expression and clinical-biological behavior of lung cancer.

Method: This study used the MaxVision two-step immunohistochemical detection method to detect Fascin-1 expression in 84 of lung cancer and paracarcinoma tissues. This study set the expression of Fascin-1 in vascular endothelial cells as the positive control, and used phosphate buffered saline (replacing the primary antibodies) as negative control.

Result: Of all the 84 lung cancer tissues and paracarcinoma tissues, positive expression of the Fascin-1 protein were detected in 78 cases (92.9%) and 27 cases (32.1%), respectively, and the difference was statistically significant (P<0.05). Differences in Fascin-1 expression between different age groups, clinical stages, and lymph node metastases were statistically significant (P<0.05), while differences in Fascin-1 expression between sexes, tumor stages, and pathological types demonstrated no statistical significance (P>0.05). The survival times of the patients with different Fascin-1 protein-positive expressions in lung cancer tissues were statistically significant (P>0.05), while the survival times of the patients with different Fascin-1 protein-positive expressions in paracarcinoma tissues were not statistically significant (P>0.05).

Conclusion: In lung cancer, Fascin-1 expression was closely related to tumor invasion and metastasis, and the difference in expression of Fascin-1 had a significant effect on the survival time of the lung cancer patients. Therefore, Fascin-1 might be expected to serve as a possible potential biomarker of lung cancer.

No MeSH data available.


Related in: MedlinePlus