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Prognostic role of LSD1 in various cancers: evidence from a meta-analysis.

Wu J, Hu L, Du Y, Kong F, Pan Y - Onco Targets Ther (2015)

Bottom Line: Eligible studies were identified by searching the online databases PubMed and China National Knowledge Infrastructure up to February 2015.Subgroup analysis by ethnicity, cancer type and HR estimate also showed that high levels of LSD1 were significantly correlated with OS.The meta-analysis showed that LSD1 overexpression may be associated with a worse prognosis in cancer patients.

View Article: PubMed Central - PubMed

Affiliation: The Central Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

ABSTRACT
The prognostic value of lysine-specific demethylase 1 (LSD1) overexpression in various cancers has been investigated by many studies with inconsistent results. A meta-analysis was performed to assess the association between LSD1 and overall survival (OS) in cancer patients. Eligible studies were identified by searching the online databases PubMed and China National Knowledge Infrastructure up to February 2015. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to clarify the correlation between LSD1 expression and prognosis of different cancers. In total, nine studies with 1,149 cancer patients were included for final analysis. The meta-analysis suggested that LSD1 overexpression was associated with poor OS in cancer patients (HR =1.80, 95% CI: 1.39-2.34, P=0.000). Subgroup analysis by ethnicity, cancer type and HR estimate also showed that high levels of LSD1 were significantly correlated with OS. The meta-analysis showed that LSD1 overexpression may be associated with a worse prognosis in cancer patients.

No MeSH data available.


Related in: MedlinePlus

Forest plots for the relationship between LSD1 expression and overall survival.Note: Weights are from random effects analysis.Abbreviation: LSD1, lysine-specific demethylase 1.
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f2-ott-8-2565: Forest plots for the relationship between LSD1 expression and overall survival.Note: Weights are from random effects analysis.Abbreviation: LSD1, lysine-specific demethylase 1.

Mentions: The main results of this meta-analysis are listed in Table 2. Our analysis suggested that LSD1 overexpression was associated with poor OS in cancer patients (HR =1.80, 95% CI: 1.39–2.34, P=0.000) with heterogeneity (I2=53.6%, P=0.028) (Figure 2).


Prognostic role of LSD1 in various cancers: evidence from a meta-analysis.

Wu J, Hu L, Du Y, Kong F, Pan Y - Onco Targets Ther (2015)

Forest plots for the relationship between LSD1 expression and overall survival.Note: Weights are from random effects analysis.Abbreviation: LSD1, lysine-specific demethylase 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592051&req=5

f2-ott-8-2565: Forest plots for the relationship between LSD1 expression and overall survival.Note: Weights are from random effects analysis.Abbreviation: LSD1, lysine-specific demethylase 1.
Mentions: The main results of this meta-analysis are listed in Table 2. Our analysis suggested that LSD1 overexpression was associated with poor OS in cancer patients (HR =1.80, 95% CI: 1.39–2.34, P=0.000) with heterogeneity (I2=53.6%, P=0.028) (Figure 2).

Bottom Line: Eligible studies were identified by searching the online databases PubMed and China National Knowledge Infrastructure up to February 2015.Subgroup analysis by ethnicity, cancer type and HR estimate also showed that high levels of LSD1 were significantly correlated with OS.The meta-analysis showed that LSD1 overexpression may be associated with a worse prognosis in cancer patients.

View Article: PubMed Central - PubMed

Affiliation: The Central Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

ABSTRACT
The prognostic value of lysine-specific demethylase 1 (LSD1) overexpression in various cancers has been investigated by many studies with inconsistent results. A meta-analysis was performed to assess the association between LSD1 and overall survival (OS) in cancer patients. Eligible studies were identified by searching the online databases PubMed and China National Knowledge Infrastructure up to February 2015. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to clarify the correlation between LSD1 expression and prognosis of different cancers. In total, nine studies with 1,149 cancer patients were included for final analysis. The meta-analysis suggested that LSD1 overexpression was associated with poor OS in cancer patients (HR =1.80, 95% CI: 1.39-2.34, P=0.000). Subgroup analysis by ethnicity, cancer type and HR estimate also showed that high levels of LSD1 were significantly correlated with OS. The meta-analysis showed that LSD1 overexpression may be associated with a worse prognosis in cancer patients.

No MeSH data available.


Related in: MedlinePlus