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Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?

Altieri R, Fontanella M, Agnoletti A, Panciani PP, Spena G, Crobeddu E, Pilloni G, Tardivo V, Lanotte M, Zenga F, Ducati A, Garbossa D - Transl Med UniSa (2014)

Bottom Line: Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology.Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization.Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, University of Turin, Italy.

ABSTRACT
Glioblastoma Multiforme, the most common and aggressive primary brain tumor, remains incurable despite of the advent of modern surgical and medical treatments. This poor prognosis depends by the recurrence after surgery and intrinsic or acquired resistance to chemotherapy and radiotherapy. Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology. Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization. Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM.

No MeSH data available.


Related in: MedlinePlus

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Mentions: The only known receptor for NO is soluble guanylyl cyclase (sGC). The α1β1 heterodimer is the predominant isoform of sGC that is obligatory for catalytic activity. NO binding at histidine 105 of β1 subunit leads to sGC activity and cGMP production (Fig 1). The NO and 3′,5′-cyclic monophosphate (NO/cGMP) pathway plays a central role in many physiological processes such as induction of vasodilation. On the other hand, the effects of NO can be attributed to the cGMP-independent pathway, which is mediated mainly by reactive oxygen/nitrogen species such as highly reactive peroxynitrite (ONOO) [23]. The role of NO and cGMP signaling in tumor biology has been extensively studied during the past three decades. NO has been shown that affect GBM in great variety of ways [24]. It is almost proved the role of NO in peritumoural and tumoural cortex, and that the increase in NOS activity may play a role in tumour vascularization and progression [25]. Many researches showing that NO treatment results in the induction of apoptosis, radiosensitization and chemosensitization in tumor cells, and in increased permeability of the BBB [26].


Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?

Altieri R, Fontanella M, Agnoletti A, Panciani PP, Spena G, Crobeddu E, Pilloni G, Tardivo V, Lanotte M, Zenga F, Ducati A, Garbossa D - Transl Med UniSa (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592044&req=5

Mentions: The only known receptor for NO is soluble guanylyl cyclase (sGC). The α1β1 heterodimer is the predominant isoform of sGC that is obligatory for catalytic activity. NO binding at histidine 105 of β1 subunit leads to sGC activity and cGMP production (Fig 1). The NO and 3′,5′-cyclic monophosphate (NO/cGMP) pathway plays a central role in many physiological processes such as induction of vasodilation. On the other hand, the effects of NO can be attributed to the cGMP-independent pathway, which is mediated mainly by reactive oxygen/nitrogen species such as highly reactive peroxynitrite (ONOO) [23]. The role of NO and cGMP signaling in tumor biology has been extensively studied during the past three decades. NO has been shown that affect GBM in great variety of ways [24]. It is almost proved the role of NO in peritumoural and tumoural cortex, and that the increase in NOS activity may play a role in tumour vascularization and progression [25]. Many researches showing that NO treatment results in the induction of apoptosis, radiosensitization and chemosensitization in tumor cells, and in increased permeability of the BBB [26].

Bottom Line: Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology.Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization.Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, University of Turin, Italy.

ABSTRACT
Glioblastoma Multiforme, the most common and aggressive primary brain tumor, remains incurable despite of the advent of modern surgical and medical treatments. This poor prognosis depends by the recurrence after surgery and intrinsic or acquired resistance to chemotherapy and radiotherapy. Nitric oxide is a small molecule that plays a key roles in glioma pathophysiology. Many researches showing that NO is involved in induction of apoptosis, radiosensitization and chemosensitization. Therefore, NO role, if clarified, may improve the knowledge about this unsolved puzzle called GBM.

No MeSH data available.


Related in: MedlinePlus