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Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N - Transl Med UniSa (2014)

Bottom Line: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level IV, therapeutic case series.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.

ABSTRACT

Background: The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.

Methods: Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

Results: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.

Conclusions: The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.

Level of evidence: Level IV, therapeutic case series.

No MeSH data available.


Related in: MedlinePlus

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Mentions: The patient underwent removal of the external fixator of the lower leg, and started treatment with teriparatide (20 μg subcutaneous injection daily), calcium and vitamin D. After 3 months of therapy, radiographs showed good integration of the bone around the nail, and adequate callus over the site of nonunion (Fig 8). Twelve months later, he started to work again and had changed sport (body building). Flexion of the knee was to 95°, extension was full.


Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N - Transl Med UniSa (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592043&req=5

Mentions: The patient underwent removal of the external fixator of the lower leg, and started treatment with teriparatide (20 μg subcutaneous injection daily), calcium and vitamin D. After 3 months of therapy, radiographs showed good integration of the bone around the nail, and adequate callus over the site of nonunion (Fig 8). Twelve months later, he started to work again and had changed sport (body building). Flexion of the knee was to 95°, extension was full.

Bottom Line: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level IV, therapeutic case series.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.

ABSTRACT

Background: The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.

Methods: Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

Results: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.

Conclusions: The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.

Level of evidence: Level IV, therapeutic case series.

No MeSH data available.


Related in: MedlinePlus