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Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N - Transl Med UniSa (2014)

Bottom Line: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level IV, therapeutic case series.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.

ABSTRACT

Background: The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.

Methods: Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

Results: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.

Conclusions: The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.

Level of evidence: Level IV, therapeutic case series.

No MeSH data available.


Related in: MedlinePlus

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Mentions: A 28-year-old healthy male nonsmoking truck driver sustained a Gustilo III 3B fracture of the left femoral shaft (32B.2 by AO classification) and left tibia and fibula (43A.3 by AO classification) (Fig 6) after a road accident. He underwent reduction and internal fixation using a reamed retrograde femoral nail, and external fixation of the fracture of the tibia and fibula. At 4 months, radiographs showed poor healing, lack of bone callus, and atrophic nonunion for both fractures (Fig 7).


Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N - Transl Med UniSa (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592043&req=5

Mentions: A 28-year-old healthy male nonsmoking truck driver sustained a Gustilo III 3B fracture of the left femoral shaft (32B.2 by AO classification) and left tibia and fibula (43A.3 by AO classification) (Fig 6) after a road accident. He underwent reduction and internal fixation using a reamed retrograde femoral nail, and external fixation of the fracture of the tibia and fibula. At 4 months, radiographs showed poor healing, lack of bone callus, and atrophic nonunion for both fractures (Fig 7).

Bottom Line: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level IV, therapeutic case series.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.

ABSTRACT

Background: The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.

Methods: Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

Results: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.

Conclusions: The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.

Level of evidence: Level IV, therapeutic case series.

No MeSH data available.


Related in: MedlinePlus