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Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N - Transl Med UniSa (2014)

Bottom Line: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level IV, therapeutic case series.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.

ABSTRACT

Background: The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.

Methods: Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

Results: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.

Conclusions: The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.

Level of evidence: Level IV, therapeutic case series.

No MeSH data available.


Related in: MedlinePlus

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Mentions: A 33-year-old healthy non-smoking male underwent reduction and external fixation of a post-traumatic (traffic accident) Gustilo III 3B fracture of the right tibia and fibula, 42A.2 according to the AO classification (Fig 4). At 5 months from surgery, given the absence of any signs of healing on radiographs, the patient underwent open reduction and reamed intramedullary nailing. At 5 months from the nailing, the patient continued to report pain, and was only able to partially weight bear with two elbow crutches. Radiographs showed lack of evident callus, and atrophic nonunion.


Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N - Transl Med UniSa (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592043&req=5

Mentions: A 33-year-old healthy non-smoking male underwent reduction and external fixation of a post-traumatic (traffic accident) Gustilo III 3B fracture of the right tibia and fibula, 42A.2 according to the AO classification (Fig 4). At 5 months from surgery, given the absence of any signs of healing on radiographs, the patient underwent open reduction and reamed intramedullary nailing. At 5 months from the nailing, the patient continued to report pain, and was only able to partially weight bear with two elbow crutches. Radiographs showed lack of evident callus, and atrophic nonunion.

Bottom Line: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level IV, therapeutic case series.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic and Trauma Surgery, Hospital "S. Maria di Loreto Nuovo", Naples, Italy.

ABSTRACT

Background: The use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.

Methods: Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

Results: Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.

Conclusions: The efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.

Level of evidence: Level IV, therapeutic case series.

No MeSH data available.


Related in: MedlinePlus