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Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review.

Bae JM, Kim EH - J Prev Med Public Health (2015)

Bottom Line: Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied.These facts support no significant effect of HRT history in the risk of breast cancer in Korean women.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.

ABSTRACT

Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women.

Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.

Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556).

Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of using mixed-effects summary estimates in 6 articles. SElogor, standard error of log odds ratio; logor, log odds ratio.
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f3-jpmph-48-5-225: Funnel plot of using mixed-effects summary estimates in 6 articles. SElogor, standard error of log odds ratio; logor, log odds ratio.

Mentions: Figure 2 displays a forest plot for the six selected articles. Because the I-squared value of 70.2% indicated heterogeneity, we applied a random effect model. In the results, the pooled ES was 0.983 (95% CI, 0.620 to 1.556), which was not statistically significant. When we performed Egger’s test, the p-value was 0.996, showing that the results were not influenced by small-scale studies, and the relevant funnel plot showed symmetry (Figure 3).


Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review.

Bae JM, Kim EH - J Prev Med Public Health (2015)

Funnel plot of using mixed-effects summary estimates in 6 articles. SElogor, standard error of log odds ratio; logor, log odds ratio.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592023&req=5

f3-jpmph-48-5-225: Funnel plot of using mixed-effects summary estimates in 6 articles. SElogor, standard error of log odds ratio; logor, log odds ratio.
Mentions: Figure 2 displays a forest plot for the six selected articles. Because the I-squared value of 70.2% indicated heterogeneity, we applied a random effect model. In the results, the pooled ES was 0.983 (95% CI, 0.620 to 1.556), which was not statistically significant. When we performed Egger’s test, the p-value was 0.996, showing that the results were not influenced by small-scale studies, and the relevant funnel plot showed symmetry (Figure 3).

Bottom Line: Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied.These facts support no significant effect of HRT history in the risk of breast cancer in Korean women.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.

ABSTRACT

Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women.

Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.

Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556).

Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

No MeSH data available.


Related in: MedlinePlus