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Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review.

Bae JM, Kim EH - J Prev Med Public Health (2015)

Bottom Line: Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied.These facts support no significant effect of HRT history in the risk of breast cancer in Korean women.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.

ABSTRACT

Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women.

Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.

Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556).

Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

No MeSH data available.


Related in: MedlinePlus

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Mentions: When we applied our search function to the five information portals, we produced a list of 20, 6, 15, 9, and 2 articles respectively, constituting a total of 52 (Figure 1). Excluding six duplicate articles, we reviewed the content of the remaining total of 46 articles, and found a total of 4 that fitted our search criteria [24-27]. Among the papers cited in these 46 articles, we also identified an additional 106 papers about Korean women, and after reviewing the contents of these we selected one more paper for our investigation [28]. Among the articles citing the original 46, we found another 66 articles about Korean women, and after reviewing the contents, we added an additional four articles for our investigation [29-32].


Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review.

Bae JM, Kim EH - J Prev Med Public Health (2015)

Flow chart of article selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4592023&req=5

f1-jpmph-48-5-225: Flow chart of article selection.
Mentions: When we applied our search function to the five information portals, we produced a list of 20, 6, 15, 9, and 2 articles respectively, constituting a total of 52 (Figure 1). Excluding six duplicate articles, we reviewed the content of the remaining total of 46 articles, and found a total of 4 that fitted our search criteria [24-27]. Among the papers cited in these 46 articles, we also identified an additional 106 papers about Korean women, and after reviewing the contents of these we selected one more paper for our investigation [28]. Among the articles citing the original 46, we found another 66 articles about Korean women, and after reviewing the contents, we added an additional four articles for our investigation [29-32].

Bottom Line: Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied.These facts support no significant effect of HRT history in the risk of breast cancer in Korean women.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.

ABSTRACT

Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women.

Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models.

Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556).

Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

No MeSH data available.


Related in: MedlinePlus