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Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire.

Keegan J, Raphael CE, Parker K, Simpson RM, Strain S, de Silva R, Di Mario C, Collinson J, Stables RH, Wage R, Drivas P, Sugathapala M, Prasad SK, Firmin DN - J Cardiovasc Magn Reson (2015)

Bottom Line: A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK. j.keegan@rbht.nhs.uk.

ABSTRACT

Background: Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.

Methods: A retrospectively-gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.

Results: When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PDV) were approximately 40 % of the peak Doppler values with a moderate - good linear relationship between the two techniques (R(2): 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

Conclusions: High temporal resolution breath-hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.

No MeSH data available.


Related in: MedlinePlus

CMR velocity at all points in the cardiac cycle against Doppler velocity for all 8 right coronary arteries and all 15 left anterior descending arteries. Linear regression lines are superimposed and the R2 values presented for each. (For all plots, x-axis is Doppler velocity in mm/s; y-axis is CMR velocity in mm/s)
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Fig6: CMR velocity at all points in the cardiac cycle against Doppler velocity for all 8 right coronary arteries and all 15 left anterior descending arteries. Linear regression lines are superimposed and the R2 values presented for each. (For all plots, x-axis is Doppler velocity in mm/s; y-axis is CMR velocity in mm/s)

Mentions: Figure 6 shows plots of the CMR measured velocities at all time points in the cardiac cycle against the corresponding Doppler velocities for all 23 vessels. Linear regressions are superimposed on each plot together with the coefficient of determination. The slopes of the regression plots vary from vessel to vessel (mean (+/−SD): 0.45 +/−0.20, range 0.20–0.93) which results in the scatter in MV, PSV and PDV seen in Fig. 4. Higher regression slopes are seen in patients in whom the heart rate during the CMR study was higher than that during the invasive study, as shown in Fig. 7. In studies where the heart rate in the CMR study was within 15 % of that in the invasive study, the regression slope was 0.35 +/−0.13. However, regardless of the value of the slope, the relationships between the CMR and Doppler velocities are linear with high coefficients of determination (mean R2 (+/−SD) = 0.79 +/−0.13). All R2 values were > 0.5 and in 74 % of vessels, R2 was ≥ 0.75.Fig. 6


Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire.

Keegan J, Raphael CE, Parker K, Simpson RM, Strain S, de Silva R, Di Mario C, Collinson J, Stables RH, Wage R, Drivas P, Sugathapala M, Prasad SK, Firmin DN - J Cardiovasc Magn Reson (2015)

CMR velocity at all points in the cardiac cycle against Doppler velocity for all 8 right coronary arteries and all 15 left anterior descending arteries. Linear regression lines are superimposed and the R2 values presented for each. (For all plots, x-axis is Doppler velocity in mm/s; y-axis is CMR velocity in mm/s)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4591589&req=5

Fig6: CMR velocity at all points in the cardiac cycle against Doppler velocity for all 8 right coronary arteries and all 15 left anterior descending arteries. Linear regression lines are superimposed and the R2 values presented for each. (For all plots, x-axis is Doppler velocity in mm/s; y-axis is CMR velocity in mm/s)
Mentions: Figure 6 shows plots of the CMR measured velocities at all time points in the cardiac cycle against the corresponding Doppler velocities for all 23 vessels. Linear regressions are superimposed on each plot together with the coefficient of determination. The slopes of the regression plots vary from vessel to vessel (mean (+/−SD): 0.45 +/−0.20, range 0.20–0.93) which results in the scatter in MV, PSV and PDV seen in Fig. 4. Higher regression slopes are seen in patients in whom the heart rate during the CMR study was higher than that during the invasive study, as shown in Fig. 7. In studies where the heart rate in the CMR study was within 15 % of that in the invasive study, the regression slope was 0.35 +/−0.13. However, regardless of the value of the slope, the relationships between the CMR and Doppler velocities are linear with high coefficients of determination (mean R2 (+/−SD) = 0.79 +/−0.13). All R2 values were > 0.5 and in 74 % of vessels, R2 was ≥ 0.75.Fig. 6

Bottom Line: A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK. j.keegan@rbht.nhs.uk.

ABSTRACT

Background: Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.

Methods: A retrospectively-gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.

Results: When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PDV) were approximately 40 % of the peak Doppler values with a moderate - good linear relationship between the two techniques (R(2): 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

Conclusions: High temporal resolution breath-hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.

No MeSH data available.


Related in: MedlinePlus