Limits...
Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire.

Keegan J, Raphael CE, Parker K, Simpson RM, Strain S, de Silva R, Di Mario C, Collinson J, Stables RH, Wage R, Drivas P, Sugathapala M, Prasad SK, Firmin DN - J Cardiovasc Magn Reson (2015)

Bottom Line: A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK. j.keegan@rbht.nhs.uk.

ABSTRACT

Background: Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.

Methods: A retrospectively-gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.

Results: When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PDV) were approximately 40 % of the peak Doppler values with a moderate - good linear relationship between the two techniques (R(2): 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

Conclusions: High temporal resolution breath-hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.

No MeSH data available.


Related in: MedlinePlus

CMR measurement of the ratio of peak diastolic velocity to peak systolic velocity (PDV/PSV) plotted against Doppler values in 8 right coronary arteries (a) and 14 left anterior descending arteries (b). (One LAD artery was excluded as it had no systolic peak)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4591589&req=5

Fig5: CMR measurement of the ratio of peak diastolic velocity to peak systolic velocity (PDV/PSV) plotted against Doppler values in 8 right coronary arteries (a) and 14 left anterior descending arteries (b). (One LAD artery was excluded as it had no systolic peak)

Mentions: Figure 5 show plots of CMR versus Doppler values of PDV/PSV for the RCAs (a) and LAD vessels (b). The relationships are linear with slopes close to unity (RCA: slope 0.90, LAD: slope 0.89) with high coefficients of determination (0.93 and 0.70 for the right and left arteries respectively).Fig. 5


Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire.

Keegan J, Raphael CE, Parker K, Simpson RM, Strain S, de Silva R, Di Mario C, Collinson J, Stables RH, Wage R, Drivas P, Sugathapala M, Prasad SK, Firmin DN - J Cardiovasc Magn Reson (2015)

CMR measurement of the ratio of peak diastolic velocity to peak systolic velocity (PDV/PSV) plotted against Doppler values in 8 right coronary arteries (a) and 14 left anterior descending arteries (b). (One LAD artery was excluded as it had no systolic peak)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4591589&req=5

Fig5: CMR measurement of the ratio of peak diastolic velocity to peak systolic velocity (PDV/PSV) plotted against Doppler values in 8 right coronary arteries (a) and 14 left anterior descending arteries (b). (One LAD artery was excluded as it had no systolic peak)
Mentions: Figure 5 show plots of CMR versus Doppler values of PDV/PSV for the RCAs (a) and LAD vessels (b). The relationships are linear with slopes close to unity (RCA: slope 0.90, LAD: slope 0.89) with high coefficients of determination (0.93 and 0.70 for the right and left arteries respectively).Fig. 5

Bottom Line: A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK. j.keegan@rbht.nhs.uk.

ABSTRACT

Background: Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning.

Methods: A retrospectively-gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data.

Results: When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PDV) were approximately 40 % of the peak Doppler values with a moderate - good linear relationship between the two techniques (R(2): 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R(2) values (mean +/-SD: 0.79 +/-.13).

Conclusions: High temporal resolution breath-hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.

No MeSH data available.


Related in: MedlinePlus