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Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes.

Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD, Rao PV - J Diabetes Metab Disord (2015)

Bottom Line: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls.The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly.Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.

ABSTRACT

Background: It is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes.

Methods: A 3-year randomized, controlled, parallel study for efficacy of Fenugreek (n = 66) and matched controls (n = 74) was conducted in men and women aged 30-70 years with criteria of prediabetes. Fenugreek powder, 5 g twice a day before meals, was given to study subjects and progression of type 2 diabetes mellitus (T2DM) was monitored at baseline and every 3 months for the 3-year study.

Results: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls. The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly. It was observed that controls had 4.2 times higher chance of developing diabetes compared to subjects in the Fenugreek group. The outcome of diabetes in Fenugreek group was positively associated with serum insulin and negatively associated with insulin resistance (HOMA IR).

Conclusions: Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

No MeSH data available.


Related in: MedlinePlus

Forest plot for multivariate analysis between independent predictor variables and the outcome
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Fig3: Forest plot for multivariate analysis between independent predictor variables and the outcome

Mentions: The odds ratio of 4.18 (p = 0.01) for the intervention group indicates that subjects in control group have 4.2 times higher chance of developing diabetes when compared to the subjects in Fenugreek group. It was observed that the outcome of diabetes in Fenugreek group was positively associated with serum insulin (OR 1.98, 95 % CI 1.30–3.02; p < 0.01) and negatively associated with HOMA IR (OR 0.07, 95 % CI 0.02–0.30; p < 0.001) (Fig. 3 and Table 4). The results of regression analysis i.e., the individual odds ratio and their confidence intervals are represented graphically by Forest plot based on logistic regression (Fig. 3).Fig. 3


Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes.

Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD, Rao PV - J Diabetes Metab Disord (2015)

Forest plot for multivariate analysis between independent predictor variables and the outcome
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4591578&req=5

Fig3: Forest plot for multivariate analysis between independent predictor variables and the outcome
Mentions: The odds ratio of 4.18 (p = 0.01) for the intervention group indicates that subjects in control group have 4.2 times higher chance of developing diabetes when compared to the subjects in Fenugreek group. It was observed that the outcome of diabetes in Fenugreek group was positively associated with serum insulin (OR 1.98, 95 % CI 1.30–3.02; p < 0.01) and negatively associated with HOMA IR (OR 0.07, 95 % CI 0.02–0.30; p < 0.001) (Fig. 3 and Table 4). The results of regression analysis i.e., the individual odds ratio and their confidence intervals are represented graphically by Forest plot based on logistic regression (Fig. 3).Fig. 3

Bottom Line: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls.The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly.Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.

ABSTRACT

Background: It is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes.

Methods: A 3-year randomized, controlled, parallel study for efficacy of Fenugreek (n = 66) and matched controls (n = 74) was conducted in men and women aged 30-70 years with criteria of prediabetes. Fenugreek powder, 5 g twice a day before meals, was given to study subjects and progression of type 2 diabetes mellitus (T2DM) was monitored at baseline and every 3 months for the 3-year study.

Results: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls. The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly. It was observed that controls had 4.2 times higher chance of developing diabetes compared to subjects in the Fenugreek group. The outcome of diabetes in Fenugreek group was positively associated with serum insulin and negatively associated with insulin resistance (HOMA IR).

Conclusions: Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

No MeSH data available.


Related in: MedlinePlus