Limits...
Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes.

Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD, Rao PV - J Diabetes Metab Disord (2015)

Bottom Line: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls.The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly.Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.

ABSTRACT

Background: It is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes.

Methods: A 3-year randomized, controlled, parallel study for efficacy of Fenugreek (n = 66) and matched controls (n = 74) was conducted in men and women aged 30-70 years with criteria of prediabetes. Fenugreek powder, 5 g twice a day before meals, was given to study subjects and progression of type 2 diabetes mellitus (T2DM) was monitored at baseline and every 3 months for the 3-year study.

Results: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls. The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly. It was observed that controls had 4.2 times higher chance of developing diabetes compared to subjects in the Fenugreek group. The outcome of diabetes in Fenugreek group was positively associated with serum insulin and negatively associated with insulin resistance (HOMA IR).

Conclusions: Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

No MeSH data available.


Related in: MedlinePlus

Cumulative Incidence Rate of Diabetes. During the study period at ½, 1, 1½, 2, 2½ and 3 years cumulative incidence rates in control and Fenugreek groups are represented
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4591578&req=5

Fig2: Cumulative Incidence Rate of Diabetes. During the study period at ½, 1, 1½, 2, 2½ and 3 years cumulative incidence rates in control and Fenugreek groups are represented

Mentions: Cumulative incidence rates of diabetes at every six months for the length of 3 years were 10.6, 24.2, 34.9, 43.9, 51.5 and 55.0 % respectively in the control and 2.7, 6.7, 10.8, 13.5, 16.2 and 23.0 % respectively in the Fenugreek group (Fig. 2). By the end of the 3-year intervention period, the cumulative incidence rate of diabetes reduced significantly in Fenugreek group compared to the control (chi-square = 13.4; p < 0.01). RRR for developing diabetes at the end of 3 years was 0.6 in Fenugreek group.Fig. 2


Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes.

Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD, Rao PV - J Diabetes Metab Disord (2015)

Cumulative Incidence Rate of Diabetes. During the study period at ½, 1, 1½, 2, 2½ and 3 years cumulative incidence rates in control and Fenugreek groups are represented
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4591578&req=5

Fig2: Cumulative Incidence Rate of Diabetes. During the study period at ½, 1, 1½, 2, 2½ and 3 years cumulative incidence rates in control and Fenugreek groups are represented
Mentions: Cumulative incidence rates of diabetes at every six months for the length of 3 years were 10.6, 24.2, 34.9, 43.9, 51.5 and 55.0 % respectively in the control and 2.7, 6.7, 10.8, 13.5, 16.2 and 23.0 % respectively in the Fenugreek group (Fig. 2). By the end of the 3-year intervention period, the cumulative incidence rate of diabetes reduced significantly in Fenugreek group compared to the control (chi-square = 13.4; p < 0.01). RRR for developing diabetes at the end of 3 years was 0.6 in Fenugreek group.Fig. 2

Bottom Line: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls.The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly.Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.

ABSTRACT

Background: It is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes.

Methods: A 3-year randomized, controlled, parallel study for efficacy of Fenugreek (n = 66) and matched controls (n = 74) was conducted in men and women aged 30-70 years with criteria of prediabetes. Fenugreek powder, 5 g twice a day before meals, was given to study subjects and progression of type 2 diabetes mellitus (T2DM) was monitored at baseline and every 3 months for the 3-year study.

Results: By the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls. The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly. It was observed that controls had 4.2 times higher chance of developing diabetes compared to subjects in the Fenugreek group. The outcome of diabetes in Fenugreek group was positively associated with serum insulin and negatively associated with insulin resistance (HOMA IR).

Conclusions: Dietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

No MeSH data available.


Related in: MedlinePlus