Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study.
Bottom Line: Population based cohort study.Among cardiovascular drugs, β blockers, calcium channel blockers, RAS blockers, and statins were associated with reduced mortality for indicated conditions.None of clopidogrel, metformin, or SSRIs/SNRIs was associated with reduced mortality.
Affiliation: Department of Internal Medicine (Geriatrics), Yale School of Medicine, New Haven, CT 06520, USA firstname.lastname@example.org.Show MeSH
Related in: MedlinePlus
Mentions: Figure 2 displays the association between each of clopidogrel, metformin, SSRIs or SNRIs, and warfarin and risk of death for participants with the conditions for which these drugs are recommended. Clopidogrel was not associated with a reduced risk of death in participants with atrial fibrillation or coronary artery disease nor was metformin in those with diabetes or SSRIs or SNRIs among participants with depression. Warfarin was associated with a reduction in death among those with atrial fibrillation (adjusted hazard ratio 0.69, 95% confidence interval 0.56 to 0.85) and thromboembolic disease (0.44, 0.30 to 0.62). The association between warfarin and risk of death was attenuated in participants with atrial fibrillation who had coexisting conditions, particularly depression, hypertension, and hyperlipidemia. The number of people with thromboembolic disease was insufficient to look at combinations of coexisting conditions.
Affiliation: Department of Internal Medicine (Geriatrics), Yale School of Medicine, New Haven, CT 06520, USA email@example.com.