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Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study.

Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG - BMJ (2015)

Bottom Line: Population based cohort study.Among cardiovascular drugs, β blockers, calcium channel blockers, RAS blockers, and statins were associated with reduced mortality for indicated conditions.None of clopidogrel, metformin, or SSRIs/SNRIs was associated with reduced mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine (Geriatrics), Yale School of Medicine, New Haven, CT 06520, USA mary.tinetti@yale.edu.

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Related in: MedlinePlus

Fig 1 Adjusted hazard ratios of death associated with guideline recommended cardiovascular drugs for older adults with chronic conditions. AF=atrial fibrillation; CAD=coronary artery disease; DEP=depression; DM=diabetes; HF=heart failure; HL=hyperlipidemia; HTN=hypertension. Hazard ratios are adjusted for the covariates described in the Methods section,as well as number of drugs other than the study drugs, and all coexisting study conditions and drugs
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fig1: Fig 1 Adjusted hazard ratios of death associated with guideline recommended cardiovascular drugs for older adults with chronic conditions. AF=atrial fibrillation; CAD=coronary artery disease; DEP=depression; DM=diabetes; HF=heart failure; HL=hyperlipidemia; HTN=hypertension. Hazard ratios are adjusted for the covariates described in the Methods section,as well as number of drugs other than the study drugs, and all coexisting study conditions and drugs

Mentions: Mortality was 26.6% (517/1946) among those with atrial fibrillation, 18.7% (707/3780) among those with coronary artery disease, 16.6% (617/3715) among those with diabetes, 32.8% (711/2169) among those with heart failure, 10.9% (747/6853) among those with hyperlipidemia, and 15.0% (1214/8074) among those with hypertension (fig 1). Figure 1 shows the associations between the guideline recommended cardiovascular drugs and the risk of death associated with each of β blockers, calcium channel blockers, RAS blockers, statins, and thiazides among participants with the cardiovascular condition for which the drugs are indicated. To explore whether the effects of these drugs differed according to the presence of different coexisting conditions, we identified participants who had common combinations of four conditions, as described in the statistical analysis section.


Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study.

Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG - BMJ (2015)

Fig 1 Adjusted hazard ratios of death associated with guideline recommended cardiovascular drugs for older adults with chronic conditions. AF=atrial fibrillation; CAD=coronary artery disease; DEP=depression; DM=diabetes; HF=heart failure; HL=hyperlipidemia; HTN=hypertension. Hazard ratios are adjusted for the covariates described in the Methods section,as well as number of drugs other than the study drugs, and all coexisting study conditions and drugs
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591503&req=5

fig1: Fig 1 Adjusted hazard ratios of death associated with guideline recommended cardiovascular drugs for older adults with chronic conditions. AF=atrial fibrillation; CAD=coronary artery disease; DEP=depression; DM=diabetes; HF=heart failure; HL=hyperlipidemia; HTN=hypertension. Hazard ratios are adjusted for the covariates described in the Methods section,as well as number of drugs other than the study drugs, and all coexisting study conditions and drugs
Mentions: Mortality was 26.6% (517/1946) among those with atrial fibrillation, 18.7% (707/3780) among those with coronary artery disease, 16.6% (617/3715) among those with diabetes, 32.8% (711/2169) among those with heart failure, 10.9% (747/6853) among those with hyperlipidemia, and 15.0% (1214/8074) among those with hypertension (fig 1). Figure 1 shows the associations between the guideline recommended cardiovascular drugs and the risk of death associated with each of β blockers, calcium channel blockers, RAS blockers, statins, and thiazides among participants with the cardiovascular condition for which the drugs are indicated. To explore whether the effects of these drugs differed according to the presence of different coexisting conditions, we identified participants who had common combinations of four conditions, as described in the statistical analysis section.

Bottom Line: Population based cohort study.Among cardiovascular drugs, β blockers, calcium channel blockers, RAS blockers, and statins were associated with reduced mortality for indicated conditions.None of clopidogrel, metformin, or SSRIs/SNRIs was associated with reduced mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine (Geriatrics), Yale School of Medicine, New Haven, CT 06520, USA mary.tinetti@yale.edu.

Show MeSH
Related in: MedlinePlus