Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study.
Bottom Line: Population based cohort study.Among cardiovascular drugs, β blockers, calcium channel blockers, RAS blockers, and statins were associated with reduced mortality for indicated conditions.None of clopidogrel, metformin, or SSRIs/SNRIs was associated with reduced mortality.
Affiliation: Department of Internal Medicine (Geriatrics), Yale School of Medicine, New Haven, CT 06520, USA firstname.lastname@example.org.Show MeSH
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Mentions: Mortality was 26.6% (517/1946) among those with atrial fibrillation, 18.7% (707/3780) among those with coronary artery disease, 16.6% (617/3715) among those with diabetes, 32.8% (711/2169) among those with heart failure, 10.9% (747/6853) among those with hyperlipidemia, and 15.0% (1214/8074) among those with hypertension (fig 1). Figure 1 shows the associations between the guideline recommended cardiovascular drugs and the risk of death associated with each of β blockers, calcium channel blockers, RAS blockers, statins, and thiazides among participants with the cardiovascular condition for which the drugs are indicated. To explore whether the effects of these drugs differed according to the presence of different coexisting conditions, we identified participants who had common combinations of four conditions, as described in the statistical analysis section.
Affiliation: Department of Internal Medicine (Geriatrics), Yale School of Medicine, New Haven, CT 06520, USA email@example.com.