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Water Selective Imaging and bSSFP Banding Artifact Correction in Humans and Small Animals at 3T and 7T, Respectively.

Ribot EJ, Wecker D, Trotier AJ, Dallaudière B, Lefrançois W, Thiaudière E, Franconi JM, Miraux S - PLoS ONE (2015)

Bottom Line: In addition, ankles, full head coverage and legs of volunteers were imaged, demonstrating the possible application of the method also for large FOV.In conclusion, this robust method can be applied in small animals and humans at high magnetic fields.The high SNR and tissue contrast obtained in short acquisition times allows to prescribe bSSFP sequence for several preclinical and clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS/University Bordeaux, Bordeaux, France.

ABSTRACT

Introduction: The purpose of this paper is to develop an easy method to generate both fat signal and banding artifact free 3D balanced Steady State Free Precession (bSSFP) images at high magnetic field.

Methods: In order to suppress fat signal and bSSFP banding artifacts, two or four images were acquired with the excitation frequency of the water-selective binomial radiofrequency pulse set On Resonance or shifted by a maximum of 3/4TR. Mice and human volunteers were imaged at 7 T and 3 T, respectively to perform whole-body and musculoskeletal imaging. "Sum-Of-Square" reconstruction was performed and combined or not with parallel imaging.

Results: The frequency selectivity of 1-2-3-2-1 or 1-3-3-1 binomial pulses was preserved after (3/4TR) frequency shifting. Consequently, whole body small animal 3D imaging was performed at 7 T and enabled visualization of small structures within adipose tissue like lymph nodes. In parallel, this method allowed 3D musculoskeletal imaging in humans with high spatial resolution at 3 T. The combination with parallel imaging allowed the acquisition of knee images with ~500 μm resolution images in less than 2 min. In addition, ankles, full head coverage and legs of volunteers were imaged, demonstrating the possible application of the method also for large FOV.

Conclusion: In conclusion, this robust method can be applied in small animals and humans at high magnetic fields. The high SNR and tissue contrast obtained in short acquisition times allows to prescribe bSSFP sequence for several preclinical and clinical applications.

No MeSH data available.


Related in: MedlinePlus

Small-animal applications of the 3D WS-bSSFP sequence at 7T.Coronal mouse whole-body images using standard bSSFP (B) and WS-bSSFP (A) sequences. Sagittal standard bSSFP (D,F) and WS-bSSFP (C,E) images showing the inguinal lymph node (C,D) and its corresponding lymphatic vessel (arrow) and a primary tumor (E,F) developing into the renal cortex (arrowhead).
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pone.0139249.g003: Small-animal applications of the 3D WS-bSSFP sequence at 7T.Coronal mouse whole-body images using standard bSSFP (B) and WS-bSSFP (A) sequences. Sagittal standard bSSFP (D,F) and WS-bSSFP (C,E) images showing the inguinal lymph node (C,D) and its corresponding lymphatic vessel (arrow) and a primary tumor (E,F) developing into the renal cortex (arrowhead).

Mentions: The 3D WS-bSSFP sequence was then validated for several applications on small animals at 7T. Whole-body imaging was performed as shown in Fig 3A and 3B. Acquiring four 3D WS-bSSFP images allowed to visualize the entire mouse body without fat signal (Fig 3A), even in areas with poor field homogeneity (lungs, abdomen). The organs were well differentiated and fluids that still appeared as hyperintense signal on the images like cerebrospinal fluid and vessels, could be then distinguished from fat signal.


Water Selective Imaging and bSSFP Banding Artifact Correction in Humans and Small Animals at 3T and 7T, Respectively.

Ribot EJ, Wecker D, Trotier AJ, Dallaudière B, Lefrançois W, Thiaudière E, Franconi JM, Miraux S - PLoS ONE (2015)

Small-animal applications of the 3D WS-bSSFP sequence at 7T.Coronal mouse whole-body images using standard bSSFP (B) and WS-bSSFP (A) sequences. Sagittal standard bSSFP (D,F) and WS-bSSFP (C,E) images showing the inguinal lymph node (C,D) and its corresponding lymphatic vessel (arrow) and a primary tumor (E,F) developing into the renal cortex (arrowhead).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591352&req=5

pone.0139249.g003: Small-animal applications of the 3D WS-bSSFP sequence at 7T.Coronal mouse whole-body images using standard bSSFP (B) and WS-bSSFP (A) sequences. Sagittal standard bSSFP (D,F) and WS-bSSFP (C,E) images showing the inguinal lymph node (C,D) and its corresponding lymphatic vessel (arrow) and a primary tumor (E,F) developing into the renal cortex (arrowhead).
Mentions: The 3D WS-bSSFP sequence was then validated for several applications on small animals at 7T. Whole-body imaging was performed as shown in Fig 3A and 3B. Acquiring four 3D WS-bSSFP images allowed to visualize the entire mouse body without fat signal (Fig 3A), even in areas with poor field homogeneity (lungs, abdomen). The organs were well differentiated and fluids that still appeared as hyperintense signal on the images like cerebrospinal fluid and vessels, could be then distinguished from fat signal.

Bottom Line: In addition, ankles, full head coverage and legs of volunteers were imaged, demonstrating the possible application of the method also for large FOV.In conclusion, this robust method can be applied in small animals and humans at high magnetic fields.The high SNR and tissue contrast obtained in short acquisition times allows to prescribe bSSFP sequence for several preclinical and clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS/University Bordeaux, Bordeaux, France.

ABSTRACT

Introduction: The purpose of this paper is to develop an easy method to generate both fat signal and banding artifact free 3D balanced Steady State Free Precession (bSSFP) images at high magnetic field.

Methods: In order to suppress fat signal and bSSFP banding artifacts, two or four images were acquired with the excitation frequency of the water-selective binomial radiofrequency pulse set On Resonance or shifted by a maximum of 3/4TR. Mice and human volunteers were imaged at 7 T and 3 T, respectively to perform whole-body and musculoskeletal imaging. "Sum-Of-Square" reconstruction was performed and combined or not with parallel imaging.

Results: The frequency selectivity of 1-2-3-2-1 or 1-3-3-1 binomial pulses was preserved after (3/4TR) frequency shifting. Consequently, whole body small animal 3D imaging was performed at 7 T and enabled visualization of small structures within adipose tissue like lymph nodes. In parallel, this method allowed 3D musculoskeletal imaging in humans with high spatial resolution at 3 T. The combination with parallel imaging allowed the acquisition of knee images with ~500 μm resolution images in less than 2 min. In addition, ankles, full head coverage and legs of volunteers were imaged, demonstrating the possible application of the method also for large FOV.

Conclusion: In conclusion, this robust method can be applied in small animals and humans at high magnetic fields. The high SNR and tissue contrast obtained in short acquisition times allows to prescribe bSSFP sequence for several preclinical and clinical applications.

No MeSH data available.


Related in: MedlinePlus