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Glaucomatous-Type Optic Discs in High Myopia.

Nagaoka N, Jonas JB, Morohoshi K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K - PLoS ONE (2015)

Bottom Line: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45).Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy.The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

ABSTRACT

Purpose: To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error of >-8 diopters or axial length ≥26.5 mm.

Methods: The hospital-based observational study included 172 patients (336 eyes) with a mean age of 61.9±12.3 years and mean axial length of 30.1±2.3 mm (range: 24.7-39.1mm). Glaucomatous-type optic discs were defined by glaucomatous optic disc appearance. Glaucoma was defined by glaucomatous optic disc appearance and glaucomatous Goldmann visual field defects not corresponding with myopic macular changes.

Results: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45). Glaucoma was detected in 94 (28%; 95% Confidence intervals: 23%, 33%) eyes. In multivariate analysis, glaucoma prevalence was 3.2 times higher (P<0.001) in megalodiscs (>3.79 mm2) than in normal-sized discs or small discs (<1.51 mm2) after adjusting for older age. Axial length was not significantly (P = 0.38) associated with glaucoma prevalence in that model. Glaucoma prevalence increased by a factor of 1.39 for each increase in optic disc area by one mm2. Again, axial length was not significantly (P = 0.38) associated with glaucoma prevalence when added to this multivariate model.

Conclusion: Within highly myopic individuals, glaucoma prevalence increased with larger optic disc size beyond a disc area of 3.8 mm2. Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy. The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

No MeSH data available.


Related in: MedlinePlus

Prevalence of glaucomatous optic nerve damage in highly myopic individuals stratified by optic disc size.In univariate analysis, the prevalence of glaucomatous-type discs increased significantly with optic disc area (P<0.001).
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pone.0138825.g002: Prevalence of glaucomatous optic nerve damage in highly myopic individuals stratified by optic disc size.In univariate analysis, the prevalence of glaucomatous-type discs increased significantly with optic disc area (P<0.001).

Mentions: Out of the 336 eyes included into the study, 105 (31.3%; 95% CI: 26%, 36%) eyes showed a glaucomatous-type optic disc (Table 1). Both examiners had disagreed in the assessment of two optic discs, which were then together assessed and discussed. The prevalence of glaucomatous-type discs did not differ significantly (P = 0.73) between the group of small discs (14/64 or 21.9%; 95% CI: 11%, 32%) and the group of normal-sized discs (42/173 or 24.3%, 95%CI: 18%, 31%) while it was significantly (P<0.001) higher in the group of megalodiscs (49/99 or 49.5%, 95% CI: 39%, 60%). In univariate analysis, the prevalence of glaucomatous-type discs increased significantly with optic disc area (P<0.001; OR: 1.29; 95%CI: 1.14, 1.47) (Fig 2), older age (P = 0.039; OR: 1.02; 95%CI: 1.001, 1.04), and with longer axial length (P<0.001; OR: 1.18; 95%CI: 1.06, 1.31). It was positively associated with taken anti-glaucomatous medication (P<0.001). The prevalence of glaucomatous-type discs was not significantly associated with gender (P = 0.49),


Glaucomatous-Type Optic Discs in High Myopia.

Nagaoka N, Jonas JB, Morohoshi K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K - PLoS ONE (2015)

Prevalence of glaucomatous optic nerve damage in highly myopic individuals stratified by optic disc size.In univariate analysis, the prevalence of glaucomatous-type discs increased significantly with optic disc area (P<0.001).
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4591327&req=5

pone.0138825.g002: Prevalence of glaucomatous optic nerve damage in highly myopic individuals stratified by optic disc size.In univariate analysis, the prevalence of glaucomatous-type discs increased significantly with optic disc area (P<0.001).
Mentions: Out of the 336 eyes included into the study, 105 (31.3%; 95% CI: 26%, 36%) eyes showed a glaucomatous-type optic disc (Table 1). Both examiners had disagreed in the assessment of two optic discs, which were then together assessed and discussed. The prevalence of glaucomatous-type discs did not differ significantly (P = 0.73) between the group of small discs (14/64 or 21.9%; 95% CI: 11%, 32%) and the group of normal-sized discs (42/173 or 24.3%, 95%CI: 18%, 31%) while it was significantly (P<0.001) higher in the group of megalodiscs (49/99 or 49.5%, 95% CI: 39%, 60%). In univariate analysis, the prevalence of glaucomatous-type discs increased significantly with optic disc area (P<0.001; OR: 1.29; 95%CI: 1.14, 1.47) (Fig 2), older age (P = 0.039; OR: 1.02; 95%CI: 1.001, 1.04), and with longer axial length (P<0.001; OR: 1.18; 95%CI: 1.06, 1.31). It was positively associated with taken anti-glaucomatous medication (P<0.001). The prevalence of glaucomatous-type discs was not significantly associated with gender (P = 0.49),

Bottom Line: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45).Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy.The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

ABSTRACT

Purpose: To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error of >-8 diopters or axial length ≥26.5 mm.

Methods: The hospital-based observational study included 172 patients (336 eyes) with a mean age of 61.9±12.3 years and mean axial length of 30.1±2.3 mm (range: 24.7-39.1mm). Glaucomatous-type optic discs were defined by glaucomatous optic disc appearance. Glaucoma was defined by glaucomatous optic disc appearance and glaucomatous Goldmann visual field defects not corresponding with myopic macular changes.

Results: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45). Glaucoma was detected in 94 (28%; 95% Confidence intervals: 23%, 33%) eyes. In multivariate analysis, glaucoma prevalence was 3.2 times higher (P<0.001) in megalodiscs (>3.79 mm2) than in normal-sized discs or small discs (<1.51 mm2) after adjusting for older age. Axial length was not significantly (P = 0.38) associated with glaucoma prevalence in that model. Glaucoma prevalence increased by a factor of 1.39 for each increase in optic disc area by one mm2. Again, axial length was not significantly (P = 0.38) associated with glaucoma prevalence when added to this multivariate model.

Conclusion: Within highly myopic individuals, glaucoma prevalence increased with larger optic disc size beyond a disc area of 3.8 mm2. Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy. The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

No MeSH data available.


Related in: MedlinePlus