Limits...
Glaucomatous-Type Optic Discs in High Myopia.

Nagaoka N, Jonas JB, Morohoshi K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K - PLoS ONE (2015)

Bottom Line: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45).Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy.The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

ABSTRACT

Purpose: To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error of >-8 diopters or axial length ≥26.5 mm.

Methods: The hospital-based observational study included 172 patients (336 eyes) with a mean age of 61.9±12.3 years and mean axial length of 30.1±2.3 mm (range: 24.7-39.1mm). Glaucomatous-type optic discs were defined by glaucomatous optic disc appearance. Glaucoma was defined by glaucomatous optic disc appearance and glaucomatous Goldmann visual field defects not corresponding with myopic macular changes.

Results: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45). Glaucoma was detected in 94 (28%; 95% Confidence intervals: 23%, 33%) eyes. In multivariate analysis, glaucoma prevalence was 3.2 times higher (P<0.001) in megalodiscs (>3.79 mm2) than in normal-sized discs or small discs (<1.51 mm2) after adjusting for older age. Axial length was not significantly (P = 0.38) associated with glaucoma prevalence in that model. Glaucoma prevalence increased by a factor of 1.39 for each increase in optic disc area by one mm2. Again, axial length was not significantly (P = 0.38) associated with glaucoma prevalence when added to this multivariate model.

Conclusion: Within highly myopic individuals, glaucoma prevalence increased with larger optic disc size beyond a disc area of 3.8 mm2. Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy. The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

No MeSH data available.


Related in: MedlinePlus

Correlation between axial length and optic disc size.In univariate analysis, optic disc area was significantly associated with axial length (P<0.001).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4591327&req=5

pone.0138825.g001: Correlation between axial length and optic disc size.In univariate analysis, optic disc area was significantly associated with axial length (P<0.001).

Mentions: Mean optic disc area was 3.18 ± 1.94 mm2 (median: 2.81 mm2). In univariate analysis, larger optic disc area was significantly associated with longer axial length (P<0.001; standardized correlation coefficient r: 0.45; equation of the regression line: Optic Disc Area (mm2) = 0.39 x Axial Length (mm)– 8.62) (Fig 1) and with younger age (P<0.001; r: -0.32).


Glaucomatous-Type Optic Discs in High Myopia.

Nagaoka N, Jonas JB, Morohoshi K, Moriyama M, Shimada N, Yoshida T, Ohno-Matsui K - PLoS ONE (2015)

Correlation between axial length and optic disc size.In univariate analysis, optic disc area was significantly associated with axial length (P<0.001).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591327&req=5

pone.0138825.g001: Correlation between axial length and optic disc size.In univariate analysis, optic disc area was significantly associated with axial length (P<0.001).
Mentions: Mean optic disc area was 3.18 ± 1.94 mm2 (median: 2.81 mm2). In univariate analysis, larger optic disc area was significantly associated with longer axial length (P<0.001; standardized correlation coefficient r: 0.45; equation of the regression line: Optic Disc Area (mm2) = 0.39 x Axial Length (mm)– 8.62) (Fig 1) and with younger age (P<0.001; r: -0.32).

Bottom Line: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45).Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy.The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

ABSTRACT

Purpose: To assess the prevalence of glaucoma in patients with high myopia defined as myopic refractive error of >-8 diopters or axial length ≥26.5 mm.

Methods: The hospital-based observational study included 172 patients (336 eyes) with a mean age of 61.9±12.3 years and mean axial length of 30.1±2.3 mm (range: 24.7-39.1mm). Glaucomatous-type optic discs were defined by glaucomatous optic disc appearance. Glaucoma was defined by glaucomatous optic disc appearance and glaucomatous Goldmann visual field defects not corresponding with myopic macular changes.

Results: Larger disc area (mean: 3.18±1.94 mm2) was associated with longer axial length (P<0.001; standardized correlation coefficient: 0.45). Glaucoma was detected in 94 (28%; 95% Confidence intervals: 23%, 33%) eyes. In multivariate analysis, glaucoma prevalence was 3.2 times higher (P<0.001) in megalodiscs (>3.79 mm2) than in normal-sized discs or small discs (<1.51 mm2) after adjusting for older age. Axial length was not significantly (P = 0.38) associated with glaucoma prevalence in that model. Glaucoma prevalence increased by a factor of 1.39 for each increase in optic disc area by one mm2. Again, axial length was not significantly (P = 0.38) associated with glaucoma prevalence when added to this multivariate model.

Conclusion: Within highly myopic individuals, glaucoma prevalence increased with larger optic disc size beyond a disc area of 3.8 mm2. Highly myopic megalodiscs as compared to normal sized discs or small discs had a 3.2 times higher risk for glaucomatous optic nerve neuropathy. The increased glaucoma prevalence in axial high myopia was primarily associated with axial myopia associated disc enlargement and not with axial elongation itself.

No MeSH data available.


Related in: MedlinePlus