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Compensatory Effect between Aortic Stiffening and Remodelling during Ageing.

Guala A, Camporeale C, Ridolfi L - PLoS ONE (2015)

Bottom Line: These two degenerative processes however, have different impacts on the arterial wave pattern.They both tend to compensate for each other, thus reducing the detrimental effect they would have had if they had arisen individually.This remarkable compensatory mechanism is investigated by a validated multi-scale model, with the aim to elucidate how aortic stiffening and remodelling quantitatively impact the complex interplay between forward and reflected backward waves in the arterial network.

View Article: PubMed Central - PubMed

Affiliation: DIATI, Politecnico di Torino, Torino, Italy.

ABSTRACT
The arterial tree exhibits a complex spatio-temporal wave pattern, whose healthy behaviour depends on a subtle balance between mechanical and geometrical properties. Several clinical studies demonstrated that such a balance progressively breaks down during ageing, when the aorta stiffens and remodels by increasing its diameter. These two degenerative processes however, have different impacts on the arterial wave pattern. They both tend to compensate for each other, thus reducing the detrimental effect they would have had if they had arisen individually. This remarkable compensatory mechanism is investigated by a validated multi-scale model, with the aim to elucidate how aortic stiffening and remodelling quantitatively impact the complex interplay between forward and reflected backward waves in the arterial network. We focus on the aorta and on the pressure at the ventricular-aortic interface, which epidemiological studies demonstrate to play a key role in cardiovascular diseases.

No MeSH data available.


Related in: MedlinePlus

Pressure waves at ascending aortic section.Upper row: total pressure, P, with physiological ageing (a), when the pulse wave velocity increase is removed (d), or the plastic geometric remodelling is not accounted (g). Middle and lower rows report the corresponding forward and backward pressures, respectively. The darker the younger, from 20 to 80 years old. Insets show the evolution of maximum and minimum pressures during ageing.
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pone.0139211.g001: Pressure waves at ascending aortic section.Upper row: total pressure, P, with physiological ageing (a), when the pulse wave velocity increase is removed (d), or the plastic geometric remodelling is not accounted (g). Middle and lower rows report the corresponding forward and backward pressures, respectively. The darker the younger, from 20 to 80 years old. Insets show the evolution of maximum and minimum pressures during ageing.

Mentions: Fig 1a shows the evolution of central pressure behaviour during ageing. At a young age, systolic portion exhibits a clear inflection between early and late systolic peaks, while diastolic decay has a weak local bump just after the dicrotic notch (marked with an arrow in Fig 1a). With age, a second late systolic peak arises, which tends to join with the first peak and overwhelms it, while inflection disappears. At the same time, diastolic decay becomes more and more regular and concave.


Compensatory Effect between Aortic Stiffening and Remodelling during Ageing.

Guala A, Camporeale C, Ridolfi L - PLoS ONE (2015)

Pressure waves at ascending aortic section.Upper row: total pressure, P, with physiological ageing (a), when the pulse wave velocity increase is removed (d), or the plastic geometric remodelling is not accounted (g). Middle and lower rows report the corresponding forward and backward pressures, respectively. The darker the younger, from 20 to 80 years old. Insets show the evolution of maximum and minimum pressures during ageing.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591291&req=5

pone.0139211.g001: Pressure waves at ascending aortic section.Upper row: total pressure, P, with physiological ageing (a), when the pulse wave velocity increase is removed (d), or the plastic geometric remodelling is not accounted (g). Middle and lower rows report the corresponding forward and backward pressures, respectively. The darker the younger, from 20 to 80 years old. Insets show the evolution of maximum and minimum pressures during ageing.
Mentions: Fig 1a shows the evolution of central pressure behaviour during ageing. At a young age, systolic portion exhibits a clear inflection between early and late systolic peaks, while diastolic decay has a weak local bump just after the dicrotic notch (marked with an arrow in Fig 1a). With age, a second late systolic peak arises, which tends to join with the first peak and overwhelms it, while inflection disappears. At the same time, diastolic decay becomes more and more regular and concave.

Bottom Line: These two degenerative processes however, have different impacts on the arterial wave pattern.They both tend to compensate for each other, thus reducing the detrimental effect they would have had if they had arisen individually.This remarkable compensatory mechanism is investigated by a validated multi-scale model, with the aim to elucidate how aortic stiffening and remodelling quantitatively impact the complex interplay between forward and reflected backward waves in the arterial network.

View Article: PubMed Central - PubMed

Affiliation: DIATI, Politecnico di Torino, Torino, Italy.

ABSTRACT
The arterial tree exhibits a complex spatio-temporal wave pattern, whose healthy behaviour depends on a subtle balance between mechanical and geometrical properties. Several clinical studies demonstrated that such a balance progressively breaks down during ageing, when the aorta stiffens and remodels by increasing its diameter. These two degenerative processes however, have different impacts on the arterial wave pattern. They both tend to compensate for each other, thus reducing the detrimental effect they would have had if they had arisen individually. This remarkable compensatory mechanism is investigated by a validated multi-scale model, with the aim to elucidate how aortic stiffening and remodelling quantitatively impact the complex interplay between forward and reflected backward waves in the arterial network. We focus on the aorta and on the pressure at the ventricular-aortic interface, which epidemiological studies demonstrate to play a key role in cardiovascular diseases.

No MeSH data available.


Related in: MedlinePlus