Limits...
Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study.

Chou YY, Lai KL, Chen DY, Lin CH, Chen HH - PLoS ONE (2015)

Bottom Line: In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56-2.29 and 1.09-1.87, respectively).For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57-2.30 and 1.09-1.67, respectively).PD was associated with an increased risk of RA development.

View Article: PubMed Central - PubMed

Affiliation: Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

ABSTRACT

Background: The risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure.

Methods and findings: This study identified 3 mutually exclusive cohorts using the 1999-2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999-2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999-2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56-2.29 and 1.09-1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57-2.30 and 1.09-1.67, respectively).

Conclusion: PD was associated with an increased risk of RA development.

No MeSH data available.


Related in: MedlinePlus

Free of incident rheumatoid arthritis rates among individuals without periodontal diseases, patients with periodontitis, and patients receiving dental scaling.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4591281&req=5

pone.0139693.g001: Free of incident rheumatoid arthritis rates among individuals without periodontal diseases, patients with periodontitis, and patients receiving dental scaling.

Mentions: As shown in Table 2, after adjusting for age, sex, and DM history, the risk of RA development was higher in PD and DS cohorts (HR, 1.89 and 1.43; 95% CI, 1.56–2.29 and 1.09–1.87, respectively) than in the non-PO cohort. Using the DS cohort as the reference cohort, the adjusted HRs (95% CIs) of RA risk for the PD and non-PO cohorts were 1.33 (1.08–1.64) and 0.70 (0.54–0.92), respectively. There were no significant differences in the associations between periodontal status and RA risk between men and women, although women had a higher risk of RA development (HR, 3.62; 95% CI, 3.19–4.11) than men. A history of treated DM was associated with a lower risk of RA development (HR, 0.65; 95% CI, 0.49–0.88), and this protective effect seemed stronger in men (HR, 0.55; 95% CI, 0.28–1.07). However, the effect of sex on the association between DM and RA risk was not statistically significant (interaction, p = 0.552). Fig 1 illustrates the rates of incident RA among the three cohorts. A survival curve for incident RA of the three cohorts is shown in Fig 1.


Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study.

Chou YY, Lai KL, Chen DY, Lin CH, Chen HH - PLoS ONE (2015)

Free of incident rheumatoid arthritis rates among individuals without periodontal diseases, patients with periodontitis, and patients receiving dental scaling.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591281&req=5

pone.0139693.g001: Free of incident rheumatoid arthritis rates among individuals without periodontal diseases, patients with periodontitis, and patients receiving dental scaling.
Mentions: As shown in Table 2, after adjusting for age, sex, and DM history, the risk of RA development was higher in PD and DS cohorts (HR, 1.89 and 1.43; 95% CI, 1.56–2.29 and 1.09–1.87, respectively) than in the non-PO cohort. Using the DS cohort as the reference cohort, the adjusted HRs (95% CIs) of RA risk for the PD and non-PO cohorts were 1.33 (1.08–1.64) and 0.70 (0.54–0.92), respectively. There were no significant differences in the associations between periodontal status and RA risk between men and women, although women had a higher risk of RA development (HR, 3.62; 95% CI, 3.19–4.11) than men. A history of treated DM was associated with a lower risk of RA development (HR, 0.65; 95% CI, 0.49–0.88), and this protective effect seemed stronger in men (HR, 0.55; 95% CI, 0.28–1.07). However, the effect of sex on the association between DM and RA risk was not statistically significant (interaction, p = 0.552). Fig 1 illustrates the rates of incident RA among the three cohorts. A survival curve for incident RA of the three cohorts is shown in Fig 1.

Bottom Line: In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56-2.29 and 1.09-1.87, respectively).For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57-2.30 and 1.09-1.67, respectively).PD was associated with an increased risk of RA development.

View Article: PubMed Central - PubMed

Affiliation: Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

ABSTRACT

Background: The risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure.

Methods and findings: This study identified 3 mutually exclusive cohorts using the 1999-2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999-2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999-2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56-2.29 and 1.09-1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57-2.30 and 1.09-1.67, respectively).

Conclusion: PD was associated with an increased risk of RA development.

No MeSH data available.


Related in: MedlinePlus