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Changes in Meningococcal Strains in the Era of a Serogroup C Vaccination Campaign: Trends and Evolution in Belgium during the Period 1997-2012.

Mattheus W, Hanquet G, Collard JM, Vanhoof R, Bertrand S - PLoS ONE (2015)

Bottom Line: This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex).The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%).

View Article: PubMed Central - PubMed

Affiliation: Sections of Bacterial Diseases, Scientific Institute of Public Health, Brussels, Belgium.

ABSTRACT

Background: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitides and septicaemia. This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.

Methods: The results are based on microbiological and molecular laboratory surveillance of 2997 clinical isolates of N. meningitides received by the Belgian Meningococcal Reference Centre (BMRC) over the period 1997-2012.

Results: Serogroup B has always been a major cause of meningococcal disease in Belgium, with P3.4 as most frequent serotype till 2008, while an increase in non-serotypable strains has been observed in the last few years. Clonal complexes cc-41/44 and cc-269 are most frequently observed in serogroup B strains. In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex). The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%). Since 2008 a difference in incidence of serogroup C was observed in Flanders (0-0.1/100,000) versus Wallonia (0.1-0.3/100,000).

Conclusion: This study showed the change in epidemiology and strain population over a 16 years period spanning an exhaustive vaccination campaign and highlights the influence of regional vaccination policies with different cohorts sizes on short and long-term IMD incidences.

No MeSH data available.


Related in: MedlinePlus

Proportional MLST distribution of serogroup B and C during the epidemic peak (2000–2002) and after the vaccination campaign (2008–2012).
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pone.0139615.g003: Proportional MLST distribution of serogroup B and C during the epidemic peak (2000–2002) and after the vaccination campaign (2008–2012).

Mentions: Analysis by multi-locus sequence typing was performed on a representative population of 276 N. meningitidis strains isolated in 2000–2002, during the peak of serogroup C meningococcal disease, and of 389 N. meningitidis strains isolated in 2008–2012 (Fig 3).


Changes in Meningococcal Strains in the Era of a Serogroup C Vaccination Campaign: Trends and Evolution in Belgium during the Period 1997-2012.

Mattheus W, Hanquet G, Collard JM, Vanhoof R, Bertrand S - PLoS ONE (2015)

Proportional MLST distribution of serogroup B and C during the epidemic peak (2000–2002) and after the vaccination campaign (2008–2012).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591272&req=5

pone.0139615.g003: Proportional MLST distribution of serogroup B and C during the epidemic peak (2000–2002) and after the vaccination campaign (2008–2012).
Mentions: Analysis by multi-locus sequence typing was performed on a representative population of 276 N. meningitidis strains isolated in 2000–2002, during the peak of serogroup C meningococcal disease, and of 389 N. meningitidis strains isolated in 2008–2012 (Fig 3).

Bottom Line: This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex).The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%).

View Article: PubMed Central - PubMed

Affiliation: Sections of Bacterial Diseases, Scientific Institute of Public Health, Brussels, Belgium.

ABSTRACT

Background: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitides and septicaemia. This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.

Methods: The results are based on microbiological and molecular laboratory surveillance of 2997 clinical isolates of N. meningitides received by the Belgian Meningococcal Reference Centre (BMRC) over the period 1997-2012.

Results: Serogroup B has always been a major cause of meningococcal disease in Belgium, with P3.4 as most frequent serotype till 2008, while an increase in non-serotypable strains has been observed in the last few years. Clonal complexes cc-41/44 and cc-269 are most frequently observed in serogroup B strains. In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex). The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%). Since 2008 a difference in incidence of serogroup C was observed in Flanders (0-0.1/100,000) versus Wallonia (0.1-0.3/100,000).

Conclusion: This study showed the change in epidemiology and strain population over a 16 years period spanning an exhaustive vaccination campaign and highlights the influence of regional vaccination policies with different cohorts sizes on short and long-term IMD incidences.

No MeSH data available.


Related in: MedlinePlus