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Changes in Meningococcal Strains in the Era of a Serogroup C Vaccination Campaign: Trends and Evolution in Belgium during the Period 1997-2012.

Mattheus W, Hanquet G, Collard JM, Vanhoof R, Bertrand S - PLoS ONE (2015)

Bottom Line: This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex).The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%).

View Article: PubMed Central - PubMed

Affiliation: Sections of Bacterial Diseases, Scientific Institute of Public Health, Brussels, Belgium.

ABSTRACT

Background: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitides and septicaemia. This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.

Methods: The results are based on microbiological and molecular laboratory surveillance of 2997 clinical isolates of N. meningitides received by the Belgian Meningococcal Reference Centre (BMRC) over the period 1997-2012.

Results: Serogroup B has always been a major cause of meningococcal disease in Belgium, with P3.4 as most frequent serotype till 2008, while an increase in non-serotypable strains has been observed in the last few years. Clonal complexes cc-41/44 and cc-269 are most frequently observed in serogroup B strains. In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex). The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%). Since 2008 a difference in incidence of serogroup C was observed in Flanders (0-0.1/100,000) versus Wallonia (0.1-0.3/100,000).

Conclusion: This study showed the change in epidemiology and strain population over a 16 years period spanning an exhaustive vaccination campaign and highlights the influence of regional vaccination policies with different cohorts sizes on short and long-term IMD incidences.

No MeSH data available.


Related in: MedlinePlus

Number of laboratory confirmed invasive meningococcal disease cases in Belgium, 1997–2012.Serogroup C vaccination period 2001–2004.
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pone.0139615.g001: Number of laboratory confirmed invasive meningococcal disease cases in Belgium, 1997–2012.Serogroup C vaccination period 2001–2004.

Mentions: From 1997 to 2012, isolates from 2997 patients (1556 males, 1429 females, 12 of unspecified gender; sex ratio 1.09) were submitted to the BMRC, the annual number of strains varying between 96 and 364 (Fig 1). Serogroup could be identified for 2983 meningococcal strains (99.5%) and serogroup B was the most common (72.5%), followed by serogroup C (22.8%), serogroup W135 (2.7%). and serogroup Y (1.8%). Other serogroups (A, X and 29E) accounted each for less than 1% of the total typed cases.


Changes in Meningococcal Strains in the Era of a Serogroup C Vaccination Campaign: Trends and Evolution in Belgium during the Period 1997-2012.

Mattheus W, Hanquet G, Collard JM, Vanhoof R, Bertrand S - PLoS ONE (2015)

Number of laboratory confirmed invasive meningococcal disease cases in Belgium, 1997–2012.Serogroup C vaccination period 2001–2004.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591272&req=5

pone.0139615.g001: Number of laboratory confirmed invasive meningococcal disease cases in Belgium, 1997–2012.Serogroup C vaccination period 2001–2004.
Mentions: From 1997 to 2012, isolates from 2997 patients (1556 males, 1429 females, 12 of unspecified gender; sex ratio 1.09) were submitted to the BMRC, the annual number of strains varying between 96 and 364 (Fig 1). Serogroup could be identified for 2983 meningococcal strains (99.5%) and serogroup B was the most common (72.5%), followed by serogroup C (22.8%), serogroup W135 (2.7%). and serogroup Y (1.8%). Other serogroups (A, X and 29E) accounted each for less than 1% of the total typed cases.

Bottom Line: This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex).The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%).

View Article: PubMed Central - PubMed

Affiliation: Sections of Bacterial Diseases, Scientific Institute of Public Health, Brussels, Belgium.

ABSTRACT

Background: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitides and septicaemia. This study shows the results of the laboratory-based surveillance of IMD in Belgium over the period 1997-2012.

Methods: The results are based on microbiological and molecular laboratory surveillance of 2997 clinical isolates of N. meningitides received by the Belgian Meningococcal Reference Centre (BMRC) over the period 1997-2012.

Results: Serogroup B has always been a major cause of meningococcal disease in Belgium, with P3.4 as most frequent serotype till 2008, while an increase in non-serotypable strains has been observed in the last few years. Clonal complexes cc-41/44 and cc-269 are most frequently observed in serogroup B strains. In the late nineties, the incidence of serogroup C disease increased considerably and peaked in 2001, mainly associated with phenotypes C:2a:P1.5,2, C:2a:P1.5 and C:2a:P1.2 (ST-11/ET-37 clonal complex). The introduction of the meningococcal C conjugate vaccine has been followed by an 88% significant decrease in serogroup C disease from 2001 to 2004 nationally, yet sharper in Flanders (92%) compared to Wallonia (77%). Since 2008 a difference in incidence of serogroup C was observed in Flanders (0-0.1/100,000) versus Wallonia (0.1-0.3/100,000).

Conclusion: This study showed the change in epidemiology and strain population over a 16 years period spanning an exhaustive vaccination campaign and highlights the influence of regional vaccination policies with different cohorts sizes on short and long-term IMD incidences.

No MeSH data available.


Related in: MedlinePlus