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Efficacy of Procyanidins against In Vivo Cellular Oxidative Damage: A Systematic Review and Meta-Analysis.

Li S, Xu M, Niu Q, Xu S, Ding Y, Yan Y, Guo S, Li F - PLoS ONE (2015)

Bottom Line: Statistically significant differences in the effects of PCs (P < 0.00001) were observed between these two methods.The effect of PCs on MDA was significantly greater in tissue samples than in serum samples (P = 0.02).The antagonistic effect may be related to intervention time, intervention method, and the source from which the indexes are estimated.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Xinjiang, China.

ABSTRACT

Aims: In this study, the efficacy of proanthocyanidins (PCs) against oxidative damage was systematically reviewed to facilitate their use in various applications.

Methods: A meta-analysis was performed by two researchers. Each investigator independently searched electronic databases, including Cochrane, PubMed, Springer, Web of Science, China National Knowledge Infrastructure (CKNI), China Science and Technology Journal Database (CSTJ), and WanFang Data, and analyzed published data from 29 studies on the effects of PCs against oxidative damage. Oxidative stress indexes included superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and total antioxidative capacity (T-AOC).

Results: Compared with the oxidative damage model group, PCs effectively improved the T-AOC, SOD, GSH, GPx, and CAT levels, and reduced the MDA levels; these differences were statistically significant (P < 0.05). In studies that used the gavage method, SOD (95% CI, 2.33-4.00) and GPx (95% CI, 2.10-4.05) were 3.16-fold and 3.08-fold higher in the PC group than in the control group, respectively. In studies that used the feeding method, SOD (95% CI, 0.32-1.74) and GPx (95% CI, -0.31 to 1.65) were 1.03-fold and 0.67-fold higher in the PC group than in the control group, respectively. Statistically significant differences in the effects of PCs (P < 0.00001) were observed between these two methods. MDA estimated from tissue samples (95% CI, -5.82 to -2.60) was 4.32-fold lower in the PC group than in the control group. In contrast, MDA estimated using serum samples (95% CI, -4.07 to -2.06) was 3.06-fold lower in the PC group than in the control group. The effect of PCs on MDA was significantly greater in tissue samples than in serum samples (P = 0.02).

Conclusion: PCs effectively antagonize oxidative damage and enhance antioxidant capacity. The antagonistic effect may be related to intervention time, intervention method, and the source from which the indexes are estimated.

No MeSH data available.


Related in: MedlinePlus

Flowchart of search strategy.The meta-analysis included animal studies that investigated the antioxidant effect of proanthocyanidins (PCs).
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pone.0139455.g001: Flowchart of search strategy.The meta-analysis included animal studies that investigated the antioxidant effect of proanthocyanidins (PCs).

Mentions: Using the search strategy, 462 articles were identified (Fig 1), of which 29 were valid for the meta-analysis according to the eligibility and exclusion criterias. [14–42] (Table 1). Mice were used as animal models in these studies, and each study investigated the effect of PCs on oxidative damage. The oxidative damage models were primarily mice induced by various substances (e.g., arsenite, H2O2, and fluorine), and the antioxidative damage models were provided various PCs as interventions. PCs were administered by feeding (n = 3) or gavage (n = 26). The PC intervention time varied among studies, and was categorized as <30 d (n = 17) or ≥30 d (n = 12). Oxidative stress indexes (i.e., MDA, SOD, GPx, T-AOC, GSH, and CAT) were examined using serum (n = 19) and tissue samples (n = 10).


Efficacy of Procyanidins against In Vivo Cellular Oxidative Damage: A Systematic Review and Meta-Analysis.

Li S, Xu M, Niu Q, Xu S, Ding Y, Yan Y, Guo S, Li F - PLoS ONE (2015)

Flowchart of search strategy.The meta-analysis included animal studies that investigated the antioxidant effect of proanthocyanidins (PCs).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591260&req=5

pone.0139455.g001: Flowchart of search strategy.The meta-analysis included animal studies that investigated the antioxidant effect of proanthocyanidins (PCs).
Mentions: Using the search strategy, 462 articles were identified (Fig 1), of which 29 were valid for the meta-analysis according to the eligibility and exclusion criterias. [14–42] (Table 1). Mice were used as animal models in these studies, and each study investigated the effect of PCs on oxidative damage. The oxidative damage models were primarily mice induced by various substances (e.g., arsenite, H2O2, and fluorine), and the antioxidative damage models were provided various PCs as interventions. PCs were administered by feeding (n = 3) or gavage (n = 26). The PC intervention time varied among studies, and was categorized as <30 d (n = 17) or ≥30 d (n = 12). Oxidative stress indexes (i.e., MDA, SOD, GPx, T-AOC, GSH, and CAT) were examined using serum (n = 19) and tissue samples (n = 10).

Bottom Line: Statistically significant differences in the effects of PCs (P < 0.00001) were observed between these two methods.The effect of PCs on MDA was significantly greater in tissue samples than in serum samples (P = 0.02).The antagonistic effect may be related to intervention time, intervention method, and the source from which the indexes are estimated.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Xinjiang, China.

ABSTRACT

Aims: In this study, the efficacy of proanthocyanidins (PCs) against oxidative damage was systematically reviewed to facilitate their use in various applications.

Methods: A meta-analysis was performed by two researchers. Each investigator independently searched electronic databases, including Cochrane, PubMed, Springer, Web of Science, China National Knowledge Infrastructure (CKNI), China Science and Technology Journal Database (CSTJ), and WanFang Data, and analyzed published data from 29 studies on the effects of PCs against oxidative damage. Oxidative stress indexes included superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and total antioxidative capacity (T-AOC).

Results: Compared with the oxidative damage model group, PCs effectively improved the T-AOC, SOD, GSH, GPx, and CAT levels, and reduced the MDA levels; these differences were statistically significant (P < 0.05). In studies that used the gavage method, SOD (95% CI, 2.33-4.00) and GPx (95% CI, 2.10-4.05) were 3.16-fold and 3.08-fold higher in the PC group than in the control group, respectively. In studies that used the feeding method, SOD (95% CI, 0.32-1.74) and GPx (95% CI, -0.31 to 1.65) were 1.03-fold and 0.67-fold higher in the PC group than in the control group, respectively. Statistically significant differences in the effects of PCs (P < 0.00001) were observed between these two methods. MDA estimated from tissue samples (95% CI, -5.82 to -2.60) was 4.32-fold lower in the PC group than in the control group. In contrast, MDA estimated using serum samples (95% CI, -4.07 to -2.06) was 3.06-fold lower in the PC group than in the control group. The effect of PCs on MDA was significantly greater in tissue samples than in serum samples (P = 0.02).

Conclusion: PCs effectively antagonize oxidative damage and enhance antioxidant capacity. The antagonistic effect may be related to intervention time, intervention method, and the source from which the indexes are estimated.

No MeSH data available.


Related in: MedlinePlus