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Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo.

Hu L, Kong D, Hu Q, Gao N, Pang S - Nanoscale Res Lett (2015)

Bottom Line: The effects of different milling times on particle size and aerodynamic performance were investigated.Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs.The aerodynamic results indicated that the DPIs displayed a good aerosol performance.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China. hbupharm@126.com.

ABSTRACT
This paper focused on formulating high-performance curcumin spray-dried powders for inhalation (curcumin-DPIs) to achieve a high lung concentration. Curcumin-DPIs were produced using wet milling combined with the spray drying method. The effects of different milling times on particle size and aerodynamic performance were investigated. The curcumin-DPIs were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution. Furthermore, the in vivo pharmacokinetic behavior and tissue distribution after pulmonary administration were also evaluated. Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs. The aerodynamic results indicated that the DPIs displayed a good aerosol performance. The plasma curcumin concentration was obviously enhanced by inhalation, and most of the curcumin-DPIs were deposited in the lung. This study demonstrated that inhalation was an effective way to carry drug to the lung, and curcumin-DPIs were hopeful for lung cancer treatment in the future.

No MeSH data available.


Related in: MedlinePlus

Dissolution profiles of curcumin-DPIs and bulk curcumin in different media
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Fig6: Dissolution profiles of curcumin-DPIs and bulk curcumin in different media

Mentions: Figure 6 showed the dissolution behavior of bulk curcumin and curcumin-DPIs. Curcumin-DPIs showed a higher dissolution of about 98 % at 4 h with 1 % SDS, 87 % with 0.5 % SDS, and 74 % with 0.3 % SDS, while the dissolution from bulk curcumin was about 90 % with 1 % SDS, 81 % with 0.5 % SDS, and 62 % with 0.3 % SDS. The dramatic increase of dissolution could be attributed to the following reason. According to the Noyes-Whitney equation, the curcumin-DPIs had a smaller size and a larger surface area with a higher apparent saturation solubility, which pronouncedly enhanced the dissolution rate. In addition, the dissolution rate could be improved significantly with the SDS concentration increasing.Fig. 6


Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo.

Hu L, Kong D, Hu Q, Gao N, Pang S - Nanoscale Res Lett (2015)

Dissolution profiles of curcumin-DPIs and bulk curcumin in different media
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591223&req=5

Fig6: Dissolution profiles of curcumin-DPIs and bulk curcumin in different media
Mentions: Figure 6 showed the dissolution behavior of bulk curcumin and curcumin-DPIs. Curcumin-DPIs showed a higher dissolution of about 98 % at 4 h with 1 % SDS, 87 % with 0.5 % SDS, and 74 % with 0.3 % SDS, while the dissolution from bulk curcumin was about 90 % with 1 % SDS, 81 % with 0.5 % SDS, and 62 % with 0.3 % SDS. The dramatic increase of dissolution could be attributed to the following reason. According to the Noyes-Whitney equation, the curcumin-DPIs had a smaller size and a larger surface area with a higher apparent saturation solubility, which pronouncedly enhanced the dissolution rate. In addition, the dissolution rate could be improved significantly with the SDS concentration increasing.Fig. 6

Bottom Line: The effects of different milling times on particle size and aerodynamic performance were investigated.Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs.The aerodynamic results indicated that the DPIs displayed a good aerosol performance.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China. hbupharm@126.com.

ABSTRACT
This paper focused on formulating high-performance curcumin spray-dried powders for inhalation (curcumin-DPIs) to achieve a high lung concentration. Curcumin-DPIs were produced using wet milling combined with the spray drying method. The effects of different milling times on particle size and aerodynamic performance were investigated. The curcumin-DPIs were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution. Furthermore, the in vivo pharmacokinetic behavior and tissue distribution after pulmonary administration were also evaluated. Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs. The aerodynamic results indicated that the DPIs displayed a good aerosol performance. The plasma curcumin concentration was obviously enhanced by inhalation, and most of the curcumin-DPIs were deposited in the lung. This study demonstrated that inhalation was an effective way to carry drug to the lung, and curcumin-DPIs were hopeful for lung cancer treatment in the future.

No MeSH data available.


Related in: MedlinePlus