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Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo.

Hu L, Kong D, Hu Q, Gao N, Pang S - Nanoscale Res Lett (2015)

Bottom Line: The effects of different milling times on particle size and aerodynamic performance were investigated.Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs.The aerodynamic results indicated that the DPIs displayed a good aerosol performance.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China. hbupharm@126.com.

ABSTRACT
This paper focused on formulating high-performance curcumin spray-dried powders for inhalation (curcumin-DPIs) to achieve a high lung concentration. Curcumin-DPIs were produced using wet milling combined with the spray drying method. The effects of different milling times on particle size and aerodynamic performance were investigated. The curcumin-DPIs were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution. Furthermore, the in vivo pharmacokinetic behavior and tissue distribution after pulmonary administration were also evaluated. Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs. The aerodynamic results indicated that the DPIs displayed a good aerosol performance. The plasma curcumin concentration was obviously enhanced by inhalation, and most of the curcumin-DPIs were deposited in the lung. This study demonstrated that inhalation was an effective way to carry drug to the lung, and curcumin-DPIs were hopeful for lung cancer treatment in the future.

No MeSH data available.


Related in: MedlinePlus

DSC curves of bulk curcumin and curcumin-DPIs milled with different times
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Fig3: DSC curves of bulk curcumin and curcumin-DPIs milled with different times

Mentions: In Fig. 3, the bulk curcumin exhibited a sharp endotherm peak with melting point at 186.2 °C, while the melting point of curcumin-DPIs was between 183.2 and 183.7 °C. The melting point of curcumin-DPIs shifted forward with significant reduction in peak intensity, and it may be caused by the interactions between curcumin and the co-grinding surfactant in the experimental process.Fig. 3


Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo.

Hu L, Kong D, Hu Q, Gao N, Pang S - Nanoscale Res Lett (2015)

DSC curves of bulk curcumin and curcumin-DPIs milled with different times
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591223&req=5

Fig3: DSC curves of bulk curcumin and curcumin-DPIs milled with different times
Mentions: In Fig. 3, the bulk curcumin exhibited a sharp endotherm peak with melting point at 186.2 °C, while the melting point of curcumin-DPIs was between 183.2 and 183.7 °C. The melting point of curcumin-DPIs shifted forward with significant reduction in peak intensity, and it may be caused by the interactions between curcumin and the co-grinding surfactant in the experimental process.Fig. 3

Bottom Line: The effects of different milling times on particle size and aerodynamic performance were investigated.Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs.The aerodynamic results indicated that the DPIs displayed a good aerosol performance.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China. hbupharm@126.com.

ABSTRACT
This paper focused on formulating high-performance curcumin spray-dried powders for inhalation (curcumin-DPIs) to achieve a high lung concentration. Curcumin-DPIs were produced using wet milling combined with the spray drying method. The effects of different milling times on particle size and aerodynamic performance were investigated. The curcumin-DPIs were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution. Furthermore, the in vivo pharmacokinetic behavior and tissue distribution after pulmonary administration were also evaluated. Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs. The aerodynamic results indicated that the DPIs displayed a good aerosol performance. The plasma curcumin concentration was obviously enhanced by inhalation, and most of the curcumin-DPIs were deposited in the lung. This study demonstrated that inhalation was an effective way to carry drug to the lung, and curcumin-DPIs were hopeful for lung cancer treatment in the future.

No MeSH data available.


Related in: MedlinePlus