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The fate and tissue disposition of deoxynivalenol in broiler chickens.

Pralatnet S, Poapolathep S, Imsilp K, Tanhan P, Isariyodom S, Kumagai S, Poapolathep A - J. Vet. Med. Sci. (2015)

Bottom Line: To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered either intravenously or orally to broilers at a dose of 1 mg/kg BW.Following intravenous administration, the values for the elimination half-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03 l/kg and 4.16 ± 0.42 l/hr/kg, respectively.These results suggest that DON is able to penetrate into the various tissues in broilers, though poorly absorbed from their gastrointestinal tract.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

ABSTRACT
To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered either intravenously or orally to broilers at a dose of 1 mg/kg BW. Concentrations of DON in plasma were measurable up to 4 hr and 2 hr after intravenous and oral administration, respectively. Following intravenous administration, the values for the elimination half-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03 l/kg and 4.16 ± 0.42 l/hr/kg, respectively. The oral bioavailability was 15.46 ± 4.02%. DON was detectable in all tissues examined after oral administration. These results suggest that DON is able to penetrate into the various tissues in broilers, though poorly absorbed from their gastrointestinal tract.

No MeSH data available.


Related in: MedlinePlus

Mean values (± SD) of deoxynivalenol concentrations in plasma broiler chickens at adosage of 1 mg/kg BW; (▲) intravenous administration, (■) oral administration (n=5).
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fig_001: Mean values (± SD) of deoxynivalenol concentrations in plasma broiler chickens at adosage of 1 mg/kg BW; (▲) intravenous administration, (■) oral administration (n=5).

Mentions: DON was detectable in plasma following a single i.v. or p.o. administration. Thesemi-logarithmic plots of the mean (± SD) plasma concentration-time curves of DON are shown inFig. 1Fig. 1.


The fate and tissue disposition of deoxynivalenol in broiler chickens.

Pralatnet S, Poapolathep S, Imsilp K, Tanhan P, Isariyodom S, Kumagai S, Poapolathep A - J. Vet. Med. Sci. (2015)

Mean values (± SD) of deoxynivalenol concentrations in plasma broiler chickens at adosage of 1 mg/kg BW; (▲) intravenous administration, (■) oral administration (n=5).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591158&req=5

fig_001: Mean values (± SD) of deoxynivalenol concentrations in plasma broiler chickens at adosage of 1 mg/kg BW; (▲) intravenous administration, (■) oral administration (n=5).
Mentions: DON was detectable in plasma following a single i.v. or p.o. administration. Thesemi-logarithmic plots of the mean (± SD) plasma concentration-time curves of DON are shown inFig. 1Fig. 1.

Bottom Line: To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered either intravenously or orally to broilers at a dose of 1 mg/kg BW.Following intravenous administration, the values for the elimination half-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03 l/kg and 4.16 ± 0.42 l/hr/kg, respectively.These results suggest that DON is able to penetrate into the various tissues in broilers, though poorly absorbed from their gastrointestinal tract.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

ABSTRACT
To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered either intravenously or orally to broilers at a dose of 1 mg/kg BW. Concentrations of DON in plasma were measurable up to 4 hr and 2 hr after intravenous and oral administration, respectively. Following intravenous administration, the values for the elimination half-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03 l/kg and 4.16 ± 0.42 l/hr/kg, respectively. The oral bioavailability was 15.46 ± 4.02%. DON was detectable in all tissues examined after oral administration. These results suggest that DON is able to penetrate into the various tissues in broilers, though poorly absorbed from their gastrointestinal tract.

No MeSH data available.


Related in: MedlinePlus