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Horizontal transmission and phylogenetic analysis of bovine leukemia virus in two districts of Miyazaki, Japan.

Mekata H, Sekiguchi S, Konnai S, Kirino Y, Horii Y, Norimine J - J. Vet. Med. Sci. (2015)

Bottom Line: Among genotype I, genetically distinct strains were spread at each farm, and cattle infected with less than 3 copies/100 cells did not transmit BLV to other cattle for more than thirty months.The data facilitate farmers and veterinarians understanding the status of BLV infected cattle.This research contributes to BLV infection control and the development of effective BLV eradication programs.

View Article: PubMed Central - PubMed

Affiliation: Project for Zoonoses Education and Research, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai-Nishi, Miyazaki 889-2192, Japan.

ABSTRACT
Horizontal transmission is recognized as a major infection route for bovine leukemia virus (BLV), and cattle with high viral loads are considered to be a major infectious source in a herd. However, a correlation between viral loads and the risk of infection has been insufficient to use as a foundation for BLV control strategies. In this report, we examined the epidemiology of BLV infection and the infectious source in a local area. In 2013-2014, BLV infection was investigated in 1,823 cattle from 117 farms in two adjacent districts, Miyazaki, Japan. Seropositive samples for BLV were detected with 88 cattle and in 14 farms. Phylogenetic analysis revealed that 94% of the isolates clustered into genotype I and the remaining isolate into genotype III. Among genotype I, genetically distinct strains were spread at each farm, and cattle infected with less than 3 copies/100 cells did not transmit BLV to other cattle for more than thirty months. This is the first report of concrete data of viral load in relation to viral horizontal transmission under the field condition. The data facilitate farmers and veterinarians understanding the status of BLV infected cattle. This research contributes to BLV infection control and the development of effective BLV eradication programs.

No MeSH data available.


Related in: MedlinePlus

A map of Miyazaki prefecture showing Kawaminami and Tsuno.
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fig_001: A map of Miyazaki prefecture showing Kawaminami and Tsuno.

Mentions: This study was conducted in the cities of Kawaminami and Tsuno, Miyazaki prefecture, Japan(Fig. 1Fig. 1.


Horizontal transmission and phylogenetic analysis of bovine leukemia virus in two districts of Miyazaki, Japan.

Mekata H, Sekiguchi S, Konnai S, Kirino Y, Horii Y, Norimine J - J. Vet. Med. Sci. (2015)

A map of Miyazaki prefecture showing Kawaminami and Tsuno.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591153&req=5

fig_001: A map of Miyazaki prefecture showing Kawaminami and Tsuno.
Mentions: This study was conducted in the cities of Kawaminami and Tsuno, Miyazaki prefecture, Japan(Fig. 1Fig. 1.

Bottom Line: Among genotype I, genetically distinct strains were spread at each farm, and cattle infected with less than 3 copies/100 cells did not transmit BLV to other cattle for more than thirty months.The data facilitate farmers and veterinarians understanding the status of BLV infected cattle.This research contributes to BLV infection control and the development of effective BLV eradication programs.

View Article: PubMed Central - PubMed

Affiliation: Project for Zoonoses Education and Research, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-Kibanadai-Nishi, Miyazaki 889-2192, Japan.

ABSTRACT
Horizontal transmission is recognized as a major infection route for bovine leukemia virus (BLV), and cattle with high viral loads are considered to be a major infectious source in a herd. However, a correlation between viral loads and the risk of infection has been insufficient to use as a foundation for BLV control strategies. In this report, we examined the epidemiology of BLV infection and the infectious source in a local area. In 2013-2014, BLV infection was investigated in 1,823 cattle from 117 farms in two adjacent districts, Miyazaki, Japan. Seropositive samples for BLV were detected with 88 cattle and in 14 farms. Phylogenetic analysis revealed that 94% of the isolates clustered into genotype I and the remaining isolate into genotype III. Among genotype I, genetically distinct strains were spread at each farm, and cattle infected with less than 3 copies/100 cells did not transmit BLV to other cattle for more than thirty months. This is the first report of concrete data of viral load in relation to viral horizontal transmission under the field condition. The data facilitate farmers and veterinarians understanding the status of BLV infected cattle. This research contributes to BLV infection control and the development of effective BLV eradication programs.

No MeSH data available.


Related in: MedlinePlus