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Assessment of left ventricular longitudinal function in cats with subclinical hypertrophic cardiomyopathy using tissue Doppler imaging and speckle tracking echocardiography.

Sugimoto K, Fujii Y, Sunahara H, Aoki T - J. Vet. Med. Sci. (2015)

Bottom Line: Conventional echocardiography, TDI, and global and segmental STE indices were evaluated and compared between groups.Only the longitudinal strain rate during early diastole was significantly decreased in both HCM groups, even in all segments including those without hypertrophy in S-HCM group.This study suggests that STE parameters are the more sensitive variables compared with conventional TDI parameters to detect early myocardial diastolic dysfunction in cats with HCM.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Surgery 1, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.

ABSTRACT
Hypertrophic cardiomyopathy (HCM) in cats is characterized by concentric left ventricular (LV) hypertrophy and both diastolic and systolic dysfunction. Although impaired cardiac function detected by tissue Doppler imaging (TDI) in cats with HCM was previously reported, reference ranges of TDI in normal cats and cats with HCM have been reported as widely variable. Two-dimensional speckle tracking echocardiography (STE) was useful for assessment of cardiac function in human patients with HCM, but clinical utility was not known in cats. The aim of this study was to assess global and segmental LV myocardial function using STE in cats with HCM whose TDI variables were within the reference range. A total of 35 cats of different breeds were enrolled in this study. The HCM group (n=22) was cats diagnosed as HCM without left atrial enlargement and with normal TDI measurements. HCM cats were further divided into a segmental hypertrophy (S-HCM) group and a diffuse hypertrophy (D-HCM) group. The control group consisted of 13 clinically healthy cats. No cats in any group showed any clinical symptoms. Conventional echocardiography, TDI, and global and segmental STE indices were evaluated and compared between groups. Only the longitudinal strain rate during early diastole was significantly decreased in both HCM groups, even in all segments including those without hypertrophy in S-HCM group. This study suggests that STE parameters are the more sensitive variables compared with conventional TDI parameters to detect early myocardial diastolic dysfunction in cats with HCM.

No MeSH data available.


Related in: MedlinePlus

Boxplot comparing global SrLe. The boxes represent the interquartile ranges.Horizontal bar represents the median value for all groups. SrLe significantlydecreased in S-HCM and D-HCM groups in comparison with the control group. **P<0.01.
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fig_002: Boxplot comparing global SrLe. The boxes represent the interquartile ranges.Horizontal bar represents the median value for all groups. SrLe significantlydecreased in S-HCM and D-HCM groups in comparison with the control group. **P<0.01.

Mentions: SL: Peak systolic longitudinal strain; SrLs: Peak longitudinal strain rate duringsystole; SrLe: Peak longitudinal strain rate during diastole; midSept: Middleseptum;apSept: Apicalseptum; apLat: Apicallateral; midLat: Middlelateral; basLat:Baselateral; NS: Not significant. *: Significant difference compared with controlgroup by multiple comparison (P<0.05) **: Significant differencecompared with control group by multiple comparison (P<0.01)


Assessment of left ventricular longitudinal function in cats with subclinical hypertrophic cardiomyopathy using tissue Doppler imaging and speckle tracking echocardiography.

Sugimoto K, Fujii Y, Sunahara H, Aoki T - J. Vet. Med. Sci. (2015)

Boxplot comparing global SrLe. The boxes represent the interquartile ranges.Horizontal bar represents the median value for all groups. SrLe significantlydecreased in S-HCM and D-HCM groups in comparison with the control group. **P<0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591151&req=5

fig_002: Boxplot comparing global SrLe. The boxes represent the interquartile ranges.Horizontal bar represents the median value for all groups. SrLe significantlydecreased in S-HCM and D-HCM groups in comparison with the control group. **P<0.01.
Mentions: SL: Peak systolic longitudinal strain; SrLs: Peak longitudinal strain rate duringsystole; SrLe: Peak longitudinal strain rate during diastole; midSept: Middleseptum;apSept: Apicalseptum; apLat: Apicallateral; midLat: Middlelateral; basLat:Baselateral; NS: Not significant. *: Significant difference compared with controlgroup by multiple comparison (P<0.05) **: Significant differencecompared with control group by multiple comparison (P<0.01)

Bottom Line: Conventional echocardiography, TDI, and global and segmental STE indices were evaluated and compared between groups.Only the longitudinal strain rate during early diastole was significantly decreased in both HCM groups, even in all segments including those without hypertrophy in S-HCM group.This study suggests that STE parameters are the more sensitive variables compared with conventional TDI parameters to detect early myocardial diastolic dysfunction in cats with HCM.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Surgery 1, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.

ABSTRACT
Hypertrophic cardiomyopathy (HCM) in cats is characterized by concentric left ventricular (LV) hypertrophy and both diastolic and systolic dysfunction. Although impaired cardiac function detected by tissue Doppler imaging (TDI) in cats with HCM was previously reported, reference ranges of TDI in normal cats and cats with HCM have been reported as widely variable. Two-dimensional speckle tracking echocardiography (STE) was useful for assessment of cardiac function in human patients with HCM, but clinical utility was not known in cats. The aim of this study was to assess global and segmental LV myocardial function using STE in cats with HCM whose TDI variables were within the reference range. A total of 35 cats of different breeds were enrolled in this study. The HCM group (n=22) was cats diagnosed as HCM without left atrial enlargement and with normal TDI measurements. HCM cats were further divided into a segmental hypertrophy (S-HCM) group and a diffuse hypertrophy (D-HCM) group. The control group consisted of 13 clinically healthy cats. No cats in any group showed any clinical symptoms. Conventional echocardiography, TDI, and global and segmental STE indices were evaluated and compared between groups. Only the longitudinal strain rate during early diastole was significantly decreased in both HCM groups, even in all segments including those without hypertrophy in S-HCM group. This study suggests that STE parameters are the more sensitive variables compared with conventional TDI parameters to detect early myocardial diastolic dysfunction in cats with HCM.

No MeSH data available.


Related in: MedlinePlus