Limits...
Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant.

Yamamoto K, Kudo M, Arito H, Ogawa Y, Takata T - Ind Health (2015)

Bottom Line: Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs) followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs.The estimated half-lives and elimination rates of PCDDs and PCDFs in the highly exposed workers increased compared with the moderately exposed workers.The estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively.

View Article: PubMed Central - PubMed

Affiliation: Occupational Health Research and Development Center, Japan Industrial Safety and Health Association, Japan.

ABSTRACT
The aim of this study was to clarify patterns of serum concentrations of dioxins in the employees of a waste incineration plant and to estimate elimination rates and half-lives of serum dioxin isomers, and the maximum serum concentrations of dioxin isomers at the time of plant shutdown. Sixteen subjects participating 3 times or more in annual health examinations during an 8-yr period from 2000 to 2007 were recruited for this study. Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs) followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs. The serum toxic equivalency (TEQ) concentrations of PCDF and PCDD congeners in the employees were higher than those in the general population survey by the Ministry of the Environment, Japan, whereas the serum concentrations of coplanar PCBs were similar to those in the general population. The estimated half-lives and elimination rates of PCDDs and PCDFs in the highly exposed workers increased compared with the moderately exposed workers. The estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively.

No MeSH data available.


Yearly changes in serum concentrations (geometric means and SDs) of PCDDs, PCDFs,coplanar PCBs and total dioxins for the highly exposed workers classified as groupIV (with means indicated by a solid line with closed circles and SDs indicated byvertical bars) and for the moderately exposed workers classified as group III (withmeans indicated by a dotted line with open circles and SDs indicated by verticalbars).
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fig_001: Yearly changes in serum concentrations (geometric means and SDs) of PCDDs, PCDFs,coplanar PCBs and total dioxins for the highly exposed workers classified as groupIV (with means indicated by a solid line with closed circles and SDs indicated byvertical bars) and for the moderately exposed workers classified as group III (withmeans indicated by a dotted line with open circles and SDs indicated by verticalbars).

Mentions: Figure 1Fig. 1.


Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant.

Yamamoto K, Kudo M, Arito H, Ogawa Y, Takata T - Ind Health (2015)

Yearly changes in serum concentrations (geometric means and SDs) of PCDDs, PCDFs,coplanar PCBs and total dioxins for the highly exposed workers classified as groupIV (with means indicated by a solid line with closed circles and SDs indicated byvertical bars) and for the moderately exposed workers classified as group III (withmeans indicated by a dotted line with open circles and SDs indicated by verticalbars).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591138&req=5

fig_001: Yearly changes in serum concentrations (geometric means and SDs) of PCDDs, PCDFs,coplanar PCBs and total dioxins for the highly exposed workers classified as groupIV (with means indicated by a solid line with closed circles and SDs indicated byvertical bars) and for the moderately exposed workers classified as group III (withmeans indicated by a dotted line with open circles and SDs indicated by verticalbars).
Mentions: Figure 1Fig. 1.

Bottom Line: Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs) followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs.The estimated half-lives and elimination rates of PCDDs and PCDFs in the highly exposed workers increased compared with the moderately exposed workers.The estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively.

View Article: PubMed Central - PubMed

Affiliation: Occupational Health Research and Development Center, Japan Industrial Safety and Health Association, Japan.

ABSTRACT
The aim of this study was to clarify patterns of serum concentrations of dioxins in the employees of a waste incineration plant and to estimate elimination rates and half-lives of serum dioxin isomers, and the maximum serum concentrations of dioxin isomers at the time of plant shutdown. Sixteen subjects participating 3 times or more in annual health examinations during an 8-yr period from 2000 to 2007 were recruited for this study. Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs) followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs. The serum toxic equivalency (TEQ) concentrations of PCDF and PCDD congeners in the employees were higher than those in the general population survey by the Ministry of the Environment, Japan, whereas the serum concentrations of coplanar PCBs were similar to those in the general population. The estimated half-lives and elimination rates of PCDDs and PCDFs in the highly exposed workers increased compared with the moderately exposed workers. The estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively.

No MeSH data available.