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Evaluation of LiF:Mg,Ti (TLD-100) for Intraoperative Electron Radiation Therapy Quality Assurance.

Liuzzi R, Savino F, D'Avino V, Pugliese M, Cella L - PLoS ONE (2015)

Bottom Line: In the dose range of 0-10 Gy, the calibration curve was confirmed to be linear for the conventional photon beam.In the same dose region, the quadratic model performs better than the linear model when high dose-per-pulse electron beams were used (F test; p<0.05).This study demonstrates that the TLD dose response, for doses ≤10 Gy, has a parabolic behavior in high dose-per-pulse electron beams.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biostructure and Bioimaging, National Research Council (CNR), Naples, Italy.

ABSTRACT

Background: Purpose of the present work was to investigate thermoluminescent dosimeters (TLDs) response to intraoperative electron radiation therapy (IOERT) beams. In an IOERT treatment, a large single radiation dose is delivered with a high dose-per-pulse electron beam (2-12 cGy/pulse) during surgery. To verify and to record the delivered dose, in vivo dosimetry is a mandatory procedure for quality assurance. The TLDs feature many advantages such as a small detector size and close tissue equivalence that make them attractive for IOERT as in vivo dosimeters.

Methods: LiF:Mg,Ti dosimeters (TLD-100) were irradiated with different IOERT electron beam energies (5, 7 and 9 MeV) and with a 6 MV conventional photon beam. For each energy, the TLDs were irradiated in the dose range of 0-10 Gy in step of 2 Gy. Regression analysis was performed to establish the response variation of thermoluminescent signals with dose and energy.

Results: The TLD-100 dose-response curves were obtained. In the dose range of 0-10 Gy, the calibration curve was confirmed to be linear for the conventional photon beam. In the same dose region, the quadratic model performs better than the linear model when high dose-per-pulse electron beams were used (F test; p<0.05).

Conclusions: This study demonstrates that the TLD dose response, for doses ≤10 Gy, has a parabolic behavior in high dose-per-pulse electron beams. TLD-100 can be useful detectors for IOERT patient dosimetry if a proper calibration is provided.

No MeSH data available.


Related in: MedlinePlus

Individual sensitivity correction factor for all forty Thermoluminescent Dosimeters (TLDs).
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pone.0139287.g003: Individual sensitivity correction factor for all forty Thermoluminescent Dosimeters (TLDs).

Mentions: Sensitivity correction factors for all TLDs were reported in Fig 3. The Si factors ranged between 0.95 and 1.05. All values were included in the range of ± 10% of the mean value, and none of TLDs was rejected. Measurements from single TLD were corrected for the corresponding Si factor.


Evaluation of LiF:Mg,Ti (TLD-100) for Intraoperative Electron Radiation Therapy Quality Assurance.

Liuzzi R, Savino F, D'Avino V, Pugliese M, Cella L - PLoS ONE (2015)

Individual sensitivity correction factor for all forty Thermoluminescent Dosimeters (TLDs).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4591127&req=5

pone.0139287.g003: Individual sensitivity correction factor for all forty Thermoluminescent Dosimeters (TLDs).
Mentions: Sensitivity correction factors for all TLDs were reported in Fig 3. The Si factors ranged between 0.95 and 1.05. All values were included in the range of ± 10% of the mean value, and none of TLDs was rejected. Measurements from single TLD were corrected for the corresponding Si factor.

Bottom Line: In the dose range of 0-10 Gy, the calibration curve was confirmed to be linear for the conventional photon beam.In the same dose region, the quadratic model performs better than the linear model when high dose-per-pulse electron beams were used (F test; p<0.05).This study demonstrates that the TLD dose response, for doses ≤10 Gy, has a parabolic behavior in high dose-per-pulse electron beams.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biostructure and Bioimaging, National Research Council (CNR), Naples, Italy.

ABSTRACT

Background: Purpose of the present work was to investigate thermoluminescent dosimeters (TLDs) response to intraoperative electron radiation therapy (IOERT) beams. In an IOERT treatment, a large single radiation dose is delivered with a high dose-per-pulse electron beam (2-12 cGy/pulse) during surgery. To verify and to record the delivered dose, in vivo dosimetry is a mandatory procedure for quality assurance. The TLDs feature many advantages such as a small detector size and close tissue equivalence that make them attractive for IOERT as in vivo dosimeters.

Methods: LiF:Mg,Ti dosimeters (TLD-100) were irradiated with different IOERT electron beam energies (5, 7 and 9 MeV) and with a 6 MV conventional photon beam. For each energy, the TLDs were irradiated in the dose range of 0-10 Gy in step of 2 Gy. Regression analysis was performed to establish the response variation of thermoluminescent signals with dose and energy.

Results: The TLD-100 dose-response curves were obtained. In the dose range of 0-10 Gy, the calibration curve was confirmed to be linear for the conventional photon beam. In the same dose region, the quadratic model performs better than the linear model when high dose-per-pulse electron beams were used (F test; p<0.05).

Conclusions: This study demonstrates that the TLD dose response, for doses ≤10 Gy, has a parabolic behavior in high dose-per-pulse electron beams. TLD-100 can be useful detectors for IOERT patient dosimetry if a proper calibration is provided.

No MeSH data available.


Related in: MedlinePlus