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A Study on the Association between Low Maternal Serum Magnesium Level and Preterm Labour.

Okunade KS, Oluwole AA, Adegbesan-Omilabu MA - Adv Med (2014)

Bottom Line: Objectives.Results.The study showed that 36% of the study patients had varying degrees of hypomagnesaemia.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria.

ABSTRACT
Objectives. The study was aimed to assess the association between low maternal serum magnesium levels and preterm labour. Methods. It is a cross-sectional case-control study in which eligible participants were pregnant women admitted in labour within the labour ward complex of a Lagos tertiary hospital. Relevant data were extracted from the case records of these women and blood samples were obtained from all participants and serum magnesium levels measured. Results. The study showed that 36% of the study patients had varying degrees of hypomagnesaemia. The relative risk indicates that preterm labour is 1.83 times higher among the patients with low serum magnesium (less than 1.6 mg/dL). The mean difference in serum magnesium levels in both groups was statistically significant (P<0.05). Conclusion. We can infer that low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour. We can, also from this finding, formulate a proposition that would help in preventing preterm labour and birth with the use of prophylactic oral magnesium supplementation among patients with higher risk for development of preterm labour.

No MeSH data available.


Related in: MedlinePlus

ROC curve for low maternal serum magnesium level (>1.6 mg/dL) and preterm labour.
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Related In: Results  -  Collection


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fig1: ROC curve for low maternal serum magnesium level (>1.6 mg/dL) and preterm labour.

Mentions: In Table 2, 36% of the study patients have varying degrees of hypomagnesaemia. It was also revealed that 47% of the case patients had serum magnesium level less than 1.6 mg/dL, whereas only 25% of the control patients had this low serum magnesium level. The relative risk (RR) indicates that the risk of preterm labour is 1.83 times higher among the patients with low serum magnesium (less than 1.6 mg/dL). The mean difference in serum magnesium level in both groups was statistically significant (P = 0.024). Table 3 shows the comparison of the present study with other previous studies on serum magnesium level in preterm labour. However, further analysis of the maternal serum magnesium cutoff value of less than 1.6 mg/dL as a predictive measure of preterm labour using the ROC curve (Figure 1) revealed that its sensitivity, specificity, positive, and negative predictive values were 50, 52, 73.8, and 60.6%, respectively.


A Study on the Association between Low Maternal Serum Magnesium Level and Preterm Labour.

Okunade KS, Oluwole AA, Adegbesan-Omilabu MA - Adv Med (2014)

ROC curve for low maternal serum magnesium level (>1.6 mg/dL) and preterm labour.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590970&req=5

fig1: ROC curve for low maternal serum magnesium level (>1.6 mg/dL) and preterm labour.
Mentions: In Table 2, 36% of the study patients have varying degrees of hypomagnesaemia. It was also revealed that 47% of the case patients had serum magnesium level less than 1.6 mg/dL, whereas only 25% of the control patients had this low serum magnesium level. The relative risk (RR) indicates that the risk of preterm labour is 1.83 times higher among the patients with low serum magnesium (less than 1.6 mg/dL). The mean difference in serum magnesium level in both groups was statistically significant (P = 0.024). Table 3 shows the comparison of the present study with other previous studies on serum magnesium level in preterm labour. However, further analysis of the maternal serum magnesium cutoff value of less than 1.6 mg/dL as a predictive measure of preterm labour using the ROC curve (Figure 1) revealed that its sensitivity, specificity, positive, and negative predictive values were 50, 52, 73.8, and 60.6%, respectively.

Bottom Line: Objectives.Results.The study showed that 36% of the study patients had varying degrees of hypomagnesaemia.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria.

ABSTRACT
Objectives. The study was aimed to assess the association between low maternal serum magnesium levels and preterm labour. Methods. It is a cross-sectional case-control study in which eligible participants were pregnant women admitted in labour within the labour ward complex of a Lagos tertiary hospital. Relevant data were extracted from the case records of these women and blood samples were obtained from all participants and serum magnesium levels measured. Results. The study showed that 36% of the study patients had varying degrees of hypomagnesaemia. The relative risk indicates that preterm labour is 1.83 times higher among the patients with low serum magnesium (less than 1.6 mg/dL). The mean difference in serum magnesium levels in both groups was statistically significant (P<0.05). Conclusion. We can infer that low serum magnesium (hypomagnesaemia) is associated with preterm onset of labour. We can, also from this finding, formulate a proposition that would help in preventing preterm labour and birth with the use of prophylactic oral magnesium supplementation among patients with higher risk for development of preterm labour.

No MeSH data available.


Related in: MedlinePlus