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Reduced Risk of Parkinson's Disease in Users of Calcium Channel Blockers: A Meta-Analysis.

Gudala K, Kanukula R, Bansal D - Int J Chronic Dis (2015)

Bottom Line: We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%).Conclusion.In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.

ABSTRACT
Aim. To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson's disease (PD). Methods. Literature search in PubMed, EBSCO, and Cochrane library was undertaken through March 2014, looking for observational studies evaluating the association between CCBs use and PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup analyses, sensitivity Analysis, and cumulative meta-analysis were also performed. Results. Six studies were included in our meta-analysis according to the selection criteria, including three cohort studies and three case-control studies involving 27,67,990 subjects including 11,941 PD cases. We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%). Both the classes of CCB, that is, dihydropyridine calcium channel blockers (DiCCB) (0.80 (95% CI, 0.65-0.98) P = 0.032) and non-DiCCB (0.70 (95% CI, 0.53-0.92) P = 0.013), were found to be reducing the risk of PD. Conclusion. In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.

No MeSH data available.


Related in: MedlinePlus

Flowchart representing the selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Flowchart representing the selection process.

Mentions: A total of 626 articles were identified during the initial search (Figure 1). After screening the titles of 626 articles, 575 articles were excluded, as they were found irrelevant. Full text of 51 articles was collected and read. After detailed evaluation, 45 articles were found to be ineligible as there were reviews, editorials, case reports, and others which did not meet the inclusion criteria (Figure 1). A total of 6 studies were included for final analysis [15–20].


Reduced Risk of Parkinson's Disease in Users of Calcium Channel Blockers: A Meta-Analysis.

Gudala K, Kanukula R, Bansal D - Int J Chronic Dis (2015)

Flowchart representing the selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590944&req=5

fig1: Flowchart representing the selection process.
Mentions: A total of 626 articles were identified during the initial search (Figure 1). After screening the titles of 626 articles, 575 articles were excluded, as they were found irrelevant. Full text of 51 articles was collected and read. After detailed evaluation, 45 articles were found to be ineligible as there were reviews, editorials, case reports, and others which did not meet the inclusion criteria (Figure 1). A total of 6 studies were included for final analysis [15–20].

Bottom Line: We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%).Conclusion.In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab 160062, India.

ABSTRACT
Aim. To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson's disease (PD). Methods. Literature search in PubMed, EBSCO, and Cochrane library was undertaken through March 2014, looking for observational studies evaluating the association between CCBs use and PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup analyses, sensitivity Analysis, and cumulative meta-analysis were also performed. Results. Six studies were included in our meta-analysis according to the selection criteria, including three cohort studies and three case-control studies involving 27,67,990 subjects including 11,941 PD cases. We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%). Both the classes of CCB, that is, dihydropyridine calcium channel blockers (DiCCB) (0.80 (95% CI, 0.65-0.98) P = 0.032) and non-DiCCB (0.70 (95% CI, 0.53-0.92) P = 0.013), were found to be reducing the risk of PD. Conclusion. In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.

No MeSH data available.


Related in: MedlinePlus