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Beneficial Effect of Low-Fat Elemental Diet Therapy on Pain in Chronic Pancreatitis.

Ikeura T, Takaoka M, Uchida K, Miyoshi H, Okazaki K - Int J Chronic Dis (2014)

Bottom Line: Mean serum levels of amylase and lipase at 8 weeks after the beginning of low-fat ED therapy decreased compared to those before the therapy.Conclusion.The therapy is recommended in outpatients with CP who present with pain despite conventional dietary and medical treatments.

View Article: PubMed Central - PubMed

Affiliation: The Third Department of Internal Medicine, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan.

ABSTRACT
Background & Aims. Chronic pancreatitis (CP) is often associated with abdominal pain, which impairs quality of life. The aim of this prospective study was to clarify whether the use of a low-fat elemental diet (ED) is beneficial for managing pain in patients with CP. Methods. Seventeen CP patients with pain despite fat-restricted dietary and conventional medical treatments were enrolled in this prospective study. These patients received low-fat ED therapy in addition to restricting fat intake for 8 weeks. The change of pain severity was examined by interviewing the patient and status of analgesic use. Results. Mean serum levels of amylase and lipase at 8 weeks after the beginning of low-fat ED therapy decreased compared to those before the therapy. At 8 weeks, pain alleviation after low-fat ED therapy was reported in 15 out of 17 patients (88%). Of these 15 patients, 10 patients reported complete pain disappearance. One of 3 patients with severe or moderate pain requiring analgesic was relieved of analgesic use after low-fat ED therapy. Conclusion. Low-fat ED therapy is useful as means of pain control in CP. The therapy is recommended in outpatients with CP who present with pain despite conventional dietary and medical treatments.

No MeSH data available.


Related in: MedlinePlus

Serum levels of amylase and lipase at 0 and 8 weeks after low-fat ED therapy. (a) Amylase. (b) Lipase.
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fig1: Serum levels of amylase and lipase at 0 and 8 weeks after low-fat ED therapy. (a) Amylase. (b) Lipase.

Mentions: Mean serum levels of amylase and lipase at 8 weeks after low-fat ED therapy decreased compared to those at 0 weeks (amylase, 48 ± 27.2 IU/L at 0 weeks versus 38.8 ± 13.5 IU/L at 8 weeks; lipase, 55.3 ± 36 IU/L at 0 weeks versus 43.8 ± 14.9 IU/L at 8 weeks), but the differences were not significant (Figure 1).


Beneficial Effect of Low-Fat Elemental Diet Therapy on Pain in Chronic Pancreatitis.

Ikeura T, Takaoka M, Uchida K, Miyoshi H, Okazaki K - Int J Chronic Dis (2014)

Serum levels of amylase and lipase at 0 and 8 weeks after low-fat ED therapy. (a) Amylase. (b) Lipase.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590936&req=5

fig1: Serum levels of amylase and lipase at 0 and 8 weeks after low-fat ED therapy. (a) Amylase. (b) Lipase.
Mentions: Mean serum levels of amylase and lipase at 8 weeks after low-fat ED therapy decreased compared to those at 0 weeks (amylase, 48 ± 27.2 IU/L at 0 weeks versus 38.8 ± 13.5 IU/L at 8 weeks; lipase, 55.3 ± 36 IU/L at 0 weeks versus 43.8 ± 14.9 IU/L at 8 weeks), but the differences were not significant (Figure 1).

Bottom Line: Mean serum levels of amylase and lipase at 8 weeks after the beginning of low-fat ED therapy decreased compared to those before the therapy.Conclusion.The therapy is recommended in outpatients with CP who present with pain despite conventional dietary and medical treatments.

View Article: PubMed Central - PubMed

Affiliation: The Third Department of Internal Medicine, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan.

ABSTRACT
Background & Aims. Chronic pancreatitis (CP) is often associated with abdominal pain, which impairs quality of life. The aim of this prospective study was to clarify whether the use of a low-fat elemental diet (ED) is beneficial for managing pain in patients with CP. Methods. Seventeen CP patients with pain despite fat-restricted dietary and conventional medical treatments were enrolled in this prospective study. These patients received low-fat ED therapy in addition to restricting fat intake for 8 weeks. The change of pain severity was examined by interviewing the patient and status of analgesic use. Results. Mean serum levels of amylase and lipase at 8 weeks after the beginning of low-fat ED therapy decreased compared to those before the therapy. At 8 weeks, pain alleviation after low-fat ED therapy was reported in 15 out of 17 patients (88%). Of these 15 patients, 10 patients reported complete pain disappearance. One of 3 patients with severe or moderate pain requiring analgesic was relieved of analgesic use after low-fat ED therapy. Conclusion. Low-fat ED therapy is useful as means of pain control in CP. The therapy is recommended in outpatients with CP who present with pain despite conventional dietary and medical treatments.

No MeSH data available.


Related in: MedlinePlus