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Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study.

Marzouk H, Lotfy HM, Farag Y, Rashed LA, El-Garf K - Int J Chronic Dis (2015)

Bottom Line: There was a statistically significant correlation between MPV and splenic span (P = 0.045).Conclusion.Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

ABSTRACT
Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P = 0.045). Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

No MeSH data available.


Related in: MedlinePlus

Correlation between MPV and splenomegaly.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Correlation between MPV and splenomegaly.

Mentions: Positive significant correlation was found between MPV and splenic span (r = 0.204, P = 0.045) (Figure 1). There was no significant correlation between MPV, CRP titer, ESR, platelet count, type of MEFV gene mutations, and colchicine treatment duration.


Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study.

Marzouk H, Lotfy HM, Farag Y, Rashed LA, El-Garf K - Int J Chronic Dis (2015)

Correlation between MPV and splenomegaly.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590932&req=5

fig1: Correlation between MPV and splenomegaly.
Mentions: Positive significant correlation was found between MPV and splenic span (r = 0.204, P = 0.045) (Figure 1). There was no significant correlation between MPV, CRP titer, ESR, platelet count, type of MEFV gene mutations, and colchicine treatment duration.

Bottom Line: There was a statistically significant correlation between MPV and splenic span (P = 0.045).Conclusion.Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

ABSTRACT
Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P = 0.045). Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

No MeSH data available.


Related in: MedlinePlus