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Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise.

Zaleski A, Capizzi J, Ballard KD, Troyanos C, Baggish A, D'Hemecourt P, Thompson PD, Parker B - J Sports Med (Hindawi Publ Corp) (2013)

Bottom Line: We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon.Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race.We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

View Article: PubMed Central - PubMed

Affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.

ABSTRACT
Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P < 0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P < 0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

No MeSH data available.


Related in: MedlinePlus

Number of cases in each quartile of soluble p-selectin after (FINISH) the marathon and 24 hours (POST) after the marathon in statin users versus controls.
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fig3: Number of cases in each quartile of soluble p-selectin after (FINISH) the marathon and 24 hours (POST) after the marathon in statin users versus controls.

Mentions: We also examined the estimated risk of future cardiovascular events using established quartiles according to p-selectin levels measured at FINISH and POST [8]. Immediately following the marathon (FINISH) the distribution of runners with a relative risk quartile above the >4th quartile cut point was significantly higher in controls versus statin using athletes (23 control versus 7 statin users; χ2 = 8.14; P < 0.01) (Figure 3). The day following the marathon (POST) controls tended to have a higher distribution of runners in the 4th quartile when compared to statin users; however, this trend did not reach statistical significance (26 control versus 13 statin users) (P = 0.07).


Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise.

Zaleski A, Capizzi J, Ballard KD, Troyanos C, Baggish A, D'Hemecourt P, Thompson PD, Parker B - J Sports Med (Hindawi Publ Corp) (2013)

Number of cases in each quartile of soluble p-selectin after (FINISH) the marathon and 24 hours (POST) after the marathon in statin users versus controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590908&req=5

fig3: Number of cases in each quartile of soluble p-selectin after (FINISH) the marathon and 24 hours (POST) after the marathon in statin users versus controls.
Mentions: We also examined the estimated risk of future cardiovascular events using established quartiles according to p-selectin levels measured at FINISH and POST [8]. Immediately following the marathon (FINISH) the distribution of runners with a relative risk quartile above the >4th quartile cut point was significantly higher in controls versus statin using athletes (23 control versus 7 statin users; χ2 = 8.14; P < 0.01) (Figure 3). The day following the marathon (POST) controls tended to have a higher distribution of runners in the 4th quartile when compared to statin users; however, this trend did not reach statistical significance (26 control versus 13 statin users) (P = 0.07).

Bottom Line: We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon.Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race.We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

View Article: PubMed Central - PubMed

Affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.

ABSTRACT
Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P < 0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P < 0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

No MeSH data available.


Related in: MedlinePlus