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Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise.

Zaleski A, Capizzi J, Ballard KD, Troyanos C, Baggish A, D'Hemecourt P, Thompson PD, Parker B - J Sports Med (Hindawi Publ Corp) (2013)

Bottom Line: We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon.Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race.We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

View Article: PubMed Central - PubMed

Affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.

ABSTRACT
Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P < 0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P < 0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

No MeSH data available.


Related in: MedlinePlus

Relationship between LDL and p-selectin immediately after (FINISH) the marathon and 24 hours (POST) after the marathon in total group.
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fig2: Relationship between LDL and p-selectin immediately after (FINISH) the marathon and 24 hours (POST) after the marathon in total group.

Mentions: LDL was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), but not at PRE (P = 0.16) (Figure 2).


Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise.

Zaleski A, Capizzi J, Ballard KD, Troyanos C, Baggish A, D'Hemecourt P, Thompson PD, Parker B - J Sports Med (Hindawi Publ Corp) (2013)

Relationship between LDL and p-selectin immediately after (FINISH) the marathon and 24 hours (POST) after the marathon in total group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590908&req=5

fig2: Relationship between LDL and p-selectin immediately after (FINISH) the marathon and 24 hours (POST) after the marathon in total group.
Mentions: LDL was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), but not at PRE (P = 0.16) (Figure 2).

Bottom Line: We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon.Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race.We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

View Article: PubMed Central - PubMed

Affiliation: Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.

ABSTRACT
Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P < 0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P < 0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

No MeSH data available.


Related in: MedlinePlus