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Hemostatic Markers in Congestive Heart Failure Dogs with Mitral Valve Disease.

Prihirunkit K, Sastravaha A, Lekcharoensuk C, Chanloinapha P - J Vet Med (2014)

Bottom Line: All of variables of MVD group, except APTT, were significantly different (P < 0.5) from control group.Additionally, TP had linear correlation with fibrinogen, D-dimer, HCT, and PLT (r = 0.31, 0.30, 0.43, and 0.38, resp., P < 0.5).These findings suggested that fibrinogen and D-dimer were the factors predisposing hypercoagulability through an increase in blood viscosity.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

ABSTRACT
Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, D-dimer, antithrombin III (AT III), protein C (PC), factor VII (F.VII), and factor VIII (F.VIII), as well as hematocrit (HCT), platelets number (PLT), total plasma protein (TP), and albumin (ALB), were studied on fifty-eight congestive heart failure (CHF) dogs with mitral valve disease (MVD) and fifty control dogs. All of variables of MVD group, except APTT, were significantly different (P < 0.5) from control group. The variables were also compared among functional classes of CHF dogs and control dogs. It was determined that the higher the functional class of CHF dogs was, the greater the levels of fibrinogen and D-dimer were, whereas the lesser the activities of AT III and PC were presented. Additionally, TP had linear correlation with fibrinogen, D-dimer, HCT, and PLT (r = 0.31, 0.30, 0.43, and 0.38, resp., P < 0.5). These findings suggested that fibrinogen and D-dimer were the factors predisposing hypercoagulability through an increase in blood viscosity. The hemorheological abnormalities would shift an overall hemostatic balance toward a more thrombotic state in CHF dogs with MVD.

No MeSH data available.


Related in: MedlinePlus

Comparison of all parameters; prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, antithrombin III (ATIII), protein C (PC), D-dimer, factor VII (F.VII), factor VIII (F.VIII), platelets number (PLT), hematocrit (HCT), total plasma protein (TP), and albumin (ALB), between dogs with mitral valve disease (MVD) and control (cont.) dogs observed in the study. Data are presented as boxes and whiskers. Each box includes the interquartile range, whereas the line within a box represents the median; the whiskers represent the range and extend to a maximum of 1.5 times the interquartile range. Outliers are depicted by circles.
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Related In: Results  -  Collection


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fig1: Comparison of all parameters; prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, antithrombin III (ATIII), protein C (PC), D-dimer, factor VII (F.VII), factor VIII (F.VIII), platelets number (PLT), hematocrit (HCT), total plasma protein (TP), and albumin (ALB), between dogs with mitral valve disease (MVD) and control (cont.) dogs observed in the study. Data are presented as boxes and whiskers. Each box includes the interquartile range, whereas the line within a box represents the median; the whiskers represent the range and extend to a maximum of 1.5 times the interquartile range. Outliers are depicted by circles.

Mentions: The comparison of selected coagulation, hematology, and blood chemistry profiles: PT, APTT, fibrinogen, D-dimer, AT III, PC, F.VII, F.VIII, hematocrit (HCT), platelets number (PLT), TP, and ALB, between MVD and control groups showed that only APTT was not statistically different (P > 0.05) (Figure 1). Those variables were also compared among functional classes of CHF dogs and control dogs. They were summarized in Table 2. It was shown that the more the functional class of CHF dogs was, the more the concentration of fibrinogen and D-dimer increased, whereas the lesser the activity of AT III and PC decreased. However, these were noted significantly (P < 0.05) in Class IV CHF dogs. PT of CHF Class III and Class IV was statistically less than that of dogs in control group (P < 0.05), but APTT was not significantly different (P > 0.05) among functional classes of CHF group and control group. According to the percentage activities of F.VII and F.VIII, only Class I CHF dogs had no significant difference (P > 0.05) compared to that of control dogs, while the levels of HCT, PLT, TP, and ALB of CHF dogs in Class II and Class III were of significant difference (P < 0.05) compared to that of dogs in control group.


Hemostatic Markers in Congestive Heart Failure Dogs with Mitral Valve Disease.

Prihirunkit K, Sastravaha A, Lekcharoensuk C, Chanloinapha P - J Vet Med (2014)

Comparison of all parameters; prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, antithrombin III (ATIII), protein C (PC), D-dimer, factor VII (F.VII), factor VIII (F.VIII), platelets number (PLT), hematocrit (HCT), total plasma protein (TP), and albumin (ALB), between dogs with mitral valve disease (MVD) and control (cont.) dogs observed in the study. Data are presented as boxes and whiskers. Each box includes the interquartile range, whereas the line within a box represents the median; the whiskers represent the range and extend to a maximum of 1.5 times the interquartile range. Outliers are depicted by circles.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590876&req=5

fig1: Comparison of all parameters; prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, antithrombin III (ATIII), protein C (PC), D-dimer, factor VII (F.VII), factor VIII (F.VIII), platelets number (PLT), hematocrit (HCT), total plasma protein (TP), and albumin (ALB), between dogs with mitral valve disease (MVD) and control (cont.) dogs observed in the study. Data are presented as boxes and whiskers. Each box includes the interquartile range, whereas the line within a box represents the median; the whiskers represent the range and extend to a maximum of 1.5 times the interquartile range. Outliers are depicted by circles.
Mentions: The comparison of selected coagulation, hematology, and blood chemistry profiles: PT, APTT, fibrinogen, D-dimer, AT III, PC, F.VII, F.VIII, hematocrit (HCT), platelets number (PLT), TP, and ALB, between MVD and control groups showed that only APTT was not statistically different (P > 0.05) (Figure 1). Those variables were also compared among functional classes of CHF dogs and control dogs. They were summarized in Table 2. It was shown that the more the functional class of CHF dogs was, the more the concentration of fibrinogen and D-dimer increased, whereas the lesser the activity of AT III and PC decreased. However, these were noted significantly (P < 0.05) in Class IV CHF dogs. PT of CHF Class III and Class IV was statistically less than that of dogs in control group (P < 0.05), but APTT was not significantly different (P > 0.05) among functional classes of CHF group and control group. According to the percentage activities of F.VII and F.VIII, only Class I CHF dogs had no significant difference (P > 0.05) compared to that of control dogs, while the levels of HCT, PLT, TP, and ALB of CHF dogs in Class II and Class III were of significant difference (P < 0.05) compared to that of dogs in control group.

Bottom Line: All of variables of MVD group, except APTT, were significantly different (P < 0.5) from control group.Additionally, TP had linear correlation with fibrinogen, D-dimer, HCT, and PLT (r = 0.31, 0.30, 0.43, and 0.38, resp., P < 0.5).These findings suggested that fibrinogen and D-dimer were the factors predisposing hypercoagulability through an increase in blood viscosity.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

ABSTRACT
Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, D-dimer, antithrombin III (AT III), protein C (PC), factor VII (F.VII), and factor VIII (F.VIII), as well as hematocrit (HCT), platelets number (PLT), total plasma protein (TP), and albumin (ALB), were studied on fifty-eight congestive heart failure (CHF) dogs with mitral valve disease (MVD) and fifty control dogs. All of variables of MVD group, except APTT, were significantly different (P < 0.5) from control group. The variables were also compared among functional classes of CHF dogs and control dogs. It was determined that the higher the functional class of CHF dogs was, the greater the levels of fibrinogen and D-dimer were, whereas the lesser the activities of AT III and PC were presented. Additionally, TP had linear correlation with fibrinogen, D-dimer, HCT, and PLT (r = 0.31, 0.30, 0.43, and 0.38, resp., P < 0.5). These findings suggested that fibrinogen and D-dimer were the factors predisposing hypercoagulability through an increase in blood viscosity. The hemorheological abnormalities would shift an overall hemostatic balance toward a more thrombotic state in CHF dogs with MVD.

No MeSH data available.


Related in: MedlinePlus