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Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats.

El-Hewaity M, Abd El Latif A, Soliman A, Aboubakr M - J Vet Med (2014)

Bottom Line: Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism.On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats.The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of El-Sadat City, Minoufiya 32897, Egypt.

ABSTRACT
The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular (IM) administrations of 2 mg/kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves were best described by two-compartment open model in both sheep and goats. The pharmacokinetics of cefquinome did not differ significantly between sheep and goats; similar intramuscular dose rate of cefquinome should therefore be applicable to both species. On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats. The in vitro serum protein-binding tendency was 15.65% in sheep and 14.42% in goats. The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These findings indicate successful use of cefquinome in sheep and goats.

No MeSH data available.


Semilogarithmic graph depicting the time-concentration of cefquinome in serum of sheep and goats after repeated intramuscular injections of 2 mg/kg b.wt. once daily for three consecutive days.
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fig1: Semilogarithmic graph depicting the time-concentration of cefquinome in serum of sheep and goats after repeated intramuscular injections of 2 mg/kg b.wt. once daily for three consecutive days.

Mentions: No clinical signs of adverse effects or intolerance were observed to cefquinome IM injection in sheep and goats. The mean serum concentrations of cefquinome in sheep and goat receiving repeated IM injections of 2 mg/kg b.wt. once daily for three consecutive days versus time are summarized in Figure 1. These data are best fitted to a two-compartment open model. The results illustrated nonsignificant increase in the serum level of cefquinome in goats compared to values recorded in sheep. Also the results showed a significant increase in serum concentrations of cefquinome after repeated doses compared to the first dose in both species sheep and goat. Cefquinome could be detected in a therapeutic concentration for 24 h post IM injection in sheep and goats. The pharmacokinetic parameters of cefquinome following repeated IM injections of 2 mg/kg b.wt. once daily for three consecutive days in sheep and goats are presented in Table 1. There were no significant differences between the pharmacokinetic parameters of cefquinome in sheep and goats after repeated IM doses. The result of in vitro protein binding study indicated that 15.65% and 14.42% of cefquinome were bound to sheep and goats serum protein, respectively.


Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats.

El-Hewaity M, Abd El Latif A, Soliman A, Aboubakr M - J Vet Med (2014)

Semilogarithmic graph depicting the time-concentration of cefquinome in serum of sheep and goats after repeated intramuscular injections of 2 mg/kg b.wt. once daily for three consecutive days.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590874&req=5

fig1: Semilogarithmic graph depicting the time-concentration of cefquinome in serum of sheep and goats after repeated intramuscular injections of 2 mg/kg b.wt. once daily for three consecutive days.
Mentions: No clinical signs of adverse effects or intolerance were observed to cefquinome IM injection in sheep and goats. The mean serum concentrations of cefquinome in sheep and goat receiving repeated IM injections of 2 mg/kg b.wt. once daily for three consecutive days versus time are summarized in Figure 1. These data are best fitted to a two-compartment open model. The results illustrated nonsignificant increase in the serum level of cefquinome in goats compared to values recorded in sheep. Also the results showed a significant increase in serum concentrations of cefquinome after repeated doses compared to the first dose in both species sheep and goat. Cefquinome could be detected in a therapeutic concentration for 24 h post IM injection in sheep and goats. The pharmacokinetic parameters of cefquinome following repeated IM injections of 2 mg/kg b.wt. once daily for three consecutive days in sheep and goats are presented in Table 1. There were no significant differences between the pharmacokinetic parameters of cefquinome in sheep and goats after repeated IM doses. The result of in vitro protein binding study indicated that 15.65% and 14.42% of cefquinome were bound to sheep and goats serum protein, respectively.

Bottom Line: Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism.On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats.The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, University of El-Sadat City, Minoufiya 32897, Egypt.

ABSTRACT
The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular (IM) administrations of 2 mg/kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341) as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves were best described by two-compartment open model in both sheep and goats. The pharmacokinetics of cefquinome did not differ significantly between sheep and goats; similar intramuscular dose rate of cefquinome should therefore be applicable to both species. On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats. The in vitro serum protein-binding tendency was 15.65% in sheep and 14.42% in goats. The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These findings indicate successful use of cefquinome in sheep and goats.

No MeSH data available.