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Hepatic Necrosis and Degenerative Myopathy Associated with Cassava Feeding in Pigs.

Daniel-Igwe G - J Vet Med (2014)

Bottom Line: The necropsy lesions included skeletal and cardiac muscle degeneration and necrosis, icterus, hepatic necrosis, and oedema of the dependent parts.The deaths and clinical signs are thought to be due to a non cyanide toxic principle in cassava, possibly the coumarins (scopoletin), which is found in high levels in cassava diet even after heat treatment.Therefore, the use of proper processing technology to obtain cassava products of high quality is recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike PMB 7267, Abia State, Nigeria.

ABSTRACT
Forty-three deaths were recorded among pigs fed boiled cassava meal at a private piggery over a period of two years. There were signs of sudden death in some cases with blood exuding from the external nares, vomiting, muscular weakness and pain or reluctance to move, emaciation, and stunted growth. The necropsy lesions included skeletal and cardiac muscle degeneration and necrosis, icterus, hepatic necrosis, and oedema of the dependent parts. The deaths and clinical signs are thought to be due to a non cyanide toxic principle in cassava, possibly the coumarins (scopoletin), which is found in high levels in cassava diet even after heat treatment. Therefore, the use of proper processing technology to obtain cassava products of high quality is recommended.

No MeSH data available.


Related in: MedlinePlus

Liver: necrosis and mononuclear cellular infiltration of the liver (He 40x).
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Related In: Results  -  Collection


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fig1: Liver: necrosis and mononuclear cellular infiltration of the liver (He 40x).

Mentions: Postmortem tissues from the liver, heart, and skeletal muscles were fixed in 10% neutral buffered formal saline, embedded in paraffin wax, and thereafter sectioned at 5 μm. The slides were stained using haematoxylin and eosin (H & E) technique. The histopathological examination of the tissues revealed that, in the acute cases, the liver lobules showed spot-like degeneration and coagulative necrosis. In the chronic cases many liver lobules showed postnecrotic collapse and fibrosis, bile duct hyperplasia and scattered partially destroyed lobules, and mononuclear cellular infiltration (Figure 1). The skeletal and cardiac muscles showed Zenker's degeneration and necrosis of the fibres and an increase in mononuclear cells and oedema between the fibres (Figures 2 and 3).


Hepatic Necrosis and Degenerative Myopathy Associated with Cassava Feeding in Pigs.

Daniel-Igwe G - J Vet Med (2014)

Liver: necrosis and mononuclear cellular infiltration of the liver (He 40x).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590868&req=5

fig1: Liver: necrosis and mononuclear cellular infiltration of the liver (He 40x).
Mentions: Postmortem tissues from the liver, heart, and skeletal muscles were fixed in 10% neutral buffered formal saline, embedded in paraffin wax, and thereafter sectioned at 5 μm. The slides were stained using haematoxylin and eosin (H & E) technique. The histopathological examination of the tissues revealed that, in the acute cases, the liver lobules showed spot-like degeneration and coagulative necrosis. In the chronic cases many liver lobules showed postnecrotic collapse and fibrosis, bile duct hyperplasia and scattered partially destroyed lobules, and mononuclear cellular infiltration (Figure 1). The skeletal and cardiac muscles showed Zenker's degeneration and necrosis of the fibres and an increase in mononuclear cells and oedema between the fibres (Figures 2 and 3).

Bottom Line: The necropsy lesions included skeletal and cardiac muscle degeneration and necrosis, icterus, hepatic necrosis, and oedema of the dependent parts.The deaths and clinical signs are thought to be due to a non cyanide toxic principle in cassava, possibly the coumarins (scopoletin), which is found in high levels in cassava diet even after heat treatment.Therefore, the use of proper processing technology to obtain cassava products of high quality is recommended.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike PMB 7267, Abia State, Nigeria.

ABSTRACT
Forty-three deaths were recorded among pigs fed boiled cassava meal at a private piggery over a period of two years. There were signs of sudden death in some cases with blood exuding from the external nares, vomiting, muscular weakness and pain or reluctance to move, emaciation, and stunted growth. The necropsy lesions included skeletal and cardiac muscle degeneration and necrosis, icterus, hepatic necrosis, and oedema of the dependent parts. The deaths and clinical signs are thought to be due to a non cyanide toxic principle in cassava, possibly the coumarins (scopoletin), which is found in high levels in cassava diet even after heat treatment. Therefore, the use of proper processing technology to obtain cassava products of high quality is recommended.

No MeSH data available.


Related in: MedlinePlus