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Assessment of Common Anaesthetic and Clinical Indices of Multimodal Therapy of Propofol, Xylazine, and Ketamine in Total Intravenous Anaesthesia in West African Dwarf Goat.

Celestine Okwudili U, Chinedu Athanasius E, Rita Ijeoma U - J Vet Med (2014)

Bottom Line: The multimodal therapy decreased significantly (P < 0.05) the heart rate in groups A, B, and D.However, temperature significantly (P < 0.05) decreased in groups A, B, and C.In conclusion, the multimodal therapy could be used successfully.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, Michael Okpara University of Agriculture, PMB 7267, Umudike, Umuahia, Abia State, Nigeria.

ABSTRACT
The assessment of anaesthetic and clinical indices of multimodal therapy of propofol, xylazine, and ketamine was done in West African Dwarf (WAD) goat. Sixteen healthy male WAD goats were assigned into four treatment groups, namely, control (group A) (ketamine 5 mg/kg + xylazine 0.05 mg/kg), group B (propofol 5 mg/kg + xylazine 0.05 mg/kg), group C (propofol 5 mg/kg + ketamine 5 mg/kg), and group D (propofol 2.5 mg/kg + ketamine 2.5 mg/kg + xylazine 0.05 mg/kg). All drugs were administered intravenously. The multimodal therapy decreased significantly (P < 0.05) the heart rate in groups A, B, and D. Also respiratory rate significantly (P < 0.05) decreased in groups A, B, and D but significantly (P < 0.05) increased at 20 min after induction in group C. However, temperature significantly (P < 0.05) decreased in groups A, B, and C. The induction was good and smooth in groups B and D. Surgical anaesthetic time was longer in groups B and D and shorter in group C. The quality of recovery was good in groups B and D. Side effects such as salivation and apnoea were observed in all groups. In conclusion, the multimodal therapy could be used successfully. However, group D could be the best combination considering the parameters measured.

No MeSH data available.


Related in: MedlinePlus

Mean heart rate following intravenous multimodal therapy of propofol, xylazine, and ketamine anaesthetics.
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Related In: Results  -  Collection


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fig1: Mean heart rate following intravenous multimodal therapy of propofol, xylazine, and ketamine anaesthetics.

Mentions: The heart rate significantly (P < 0.05) decreased in groups A, B, and D following induction when compared to group C. The heart rate was significantly (P < 0.05) lower in group A from 20 min to 40 min after induction when compared to other groups. However, the heart rate was significantly (P < 0.05) decreased in groups B and D at 60 min when compared to the control (group A). On the contrary, the heart rate significantly (P < 0.05) increased at 20 min after induction in group C (Figure 1).


Assessment of Common Anaesthetic and Clinical Indices of Multimodal Therapy of Propofol, Xylazine, and Ketamine in Total Intravenous Anaesthesia in West African Dwarf Goat.

Celestine Okwudili U, Chinedu Athanasius E, Rita Ijeoma U - J Vet Med (2014)

Mean heart rate following intravenous multimodal therapy of propofol, xylazine, and ketamine anaesthetics.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590866&req=5

fig1: Mean heart rate following intravenous multimodal therapy of propofol, xylazine, and ketamine anaesthetics.
Mentions: The heart rate significantly (P < 0.05) decreased in groups A, B, and D following induction when compared to group C. The heart rate was significantly (P < 0.05) lower in group A from 20 min to 40 min after induction when compared to other groups. However, the heart rate was significantly (P < 0.05) decreased in groups B and D at 60 min when compared to the control (group A). On the contrary, the heart rate significantly (P < 0.05) increased at 20 min after induction in group C (Figure 1).

Bottom Line: The multimodal therapy decreased significantly (P < 0.05) the heart rate in groups A, B, and D.However, temperature significantly (P < 0.05) decreased in groups A, B, and C.In conclusion, the multimodal therapy could be used successfully.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, Michael Okpara University of Agriculture, PMB 7267, Umudike, Umuahia, Abia State, Nigeria.

ABSTRACT
The assessment of anaesthetic and clinical indices of multimodal therapy of propofol, xylazine, and ketamine was done in West African Dwarf (WAD) goat. Sixteen healthy male WAD goats were assigned into four treatment groups, namely, control (group A) (ketamine 5 mg/kg + xylazine 0.05 mg/kg), group B (propofol 5 mg/kg + xylazine 0.05 mg/kg), group C (propofol 5 mg/kg + ketamine 5 mg/kg), and group D (propofol 2.5 mg/kg + ketamine 2.5 mg/kg + xylazine 0.05 mg/kg). All drugs were administered intravenously. The multimodal therapy decreased significantly (P < 0.05) the heart rate in groups A, B, and D. Also respiratory rate significantly (P < 0.05) decreased in groups A, B, and D but significantly (P < 0.05) increased at 20 min after induction in group C. However, temperature significantly (P < 0.05) decreased in groups A, B, and C. The induction was good and smooth in groups B and D. Surgical anaesthetic time was longer in groups B and D and shorter in group C. The quality of recovery was good in groups B and D. Side effects such as salivation and apnoea were observed in all groups. In conclusion, the multimodal therapy could be used successfully. However, group D could be the best combination considering the parameters measured.

No MeSH data available.


Related in: MedlinePlus