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An Antioxidant Dietary Supplement Improves Brain-Derived Neurotrophic Factor Levels in Serum of Aged Dogs: Preliminary Results.

Sechi S, Chiavolelli F, Spissu N, Di Cerbo A, Canello S, Guidetti G, Fiore F, Cocco R - J Vet Med (2015)

Bottom Line: Our results showed that a dietary regime, enriched with antioxidants, induced a significant decrease of plasma levels of dROMs (p < 0.005) and a significant increase in BDNF serum levels (p < 0.005) after six months.Thus, we hypothesized a possible role of the diet in modulating pro- and antioxidant species as well as BDNF levels in plasma and serum, respectively.In conclusion the proposed diet enriched with antioxidants might be considered a valid alternative and a valuable strategy to counteract aging-related cognitive decline in elderly dogs.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via Vienna 2, 07100 Sassari, Italy.

ABSTRACT
Biological aging is characterized by a progressive accumulation of oxidative damage and decreased endogenous antioxidant defense mechanisms. The production of oxidants by normal metabolism damages proteins, lipids, and nucleotides, which may contribute to cognitive impairment. In this study 36 dogs were randomly divided into four groups and fed croquettes of different compositions for 6 months. We monitored derivatives of reactive oxygen metabolites (dROMs) and biological antioxidant potential (BAP) levels in dogs' plasma samples as well as brain-derived neurotrophic factor (BDNF) serum levels at the beginning and at the end of the dietary regime. Our results showed that a dietary regime, enriched with antioxidants, induced a significant decrease of plasma levels of dROMs (p < 0.005) and a significant increase in BDNF serum levels (p < 0.005) after six months. Thus, we hypothesized a possible role of the diet in modulating pro- and antioxidant species as well as BDNF levels in plasma and serum, respectively. In conclusion the proposed diet enriched with antioxidants might be considered a valid alternative and a valuable strategy to counteract aging-related cognitive decline in elderly dogs.

No MeSH data available.


Related in: MedlinePlus

Graphical representation of dROMs in plasma of aged dogs before and after the 6 months of the dietary regime. A significant decrease of dROMs levels was observed in dogs fed with antioxidant supplementation, in the second group (∗∗p < 0.005) and in the fourth group (∗∗p < 0.005), respectively.
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fig1: Graphical representation of dROMs in plasma of aged dogs before and after the 6 months of the dietary regime. A significant decrease of dROMs levels was observed in dogs fed with antioxidant supplementation, in the second group (∗∗p < 0.005) and in the fourth group (∗∗p < 0.005), respectively.

Mentions: As shown in Figure 1, a significant decrease in plasma levels of dROMs, after six months of feeding regime, in groups 2 and 4 (food supplemented with antioxidant) was observed (p < 0.005). dROMs levels remained unaltered in the first (control group) and third groups (fish-based meal, without antioxidant addition).


An Antioxidant Dietary Supplement Improves Brain-Derived Neurotrophic Factor Levels in Serum of Aged Dogs: Preliminary Results.

Sechi S, Chiavolelli F, Spissu N, Di Cerbo A, Canello S, Guidetti G, Fiore F, Cocco R - J Vet Med (2015)

Graphical representation of dROMs in plasma of aged dogs before and after the 6 months of the dietary regime. A significant decrease of dROMs levels was observed in dogs fed with antioxidant supplementation, in the second group (∗∗p < 0.005) and in the fourth group (∗∗p < 0.005), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590864&req=5

fig1: Graphical representation of dROMs in plasma of aged dogs before and after the 6 months of the dietary regime. A significant decrease of dROMs levels was observed in dogs fed with antioxidant supplementation, in the second group (∗∗p < 0.005) and in the fourth group (∗∗p < 0.005), respectively.
Mentions: As shown in Figure 1, a significant decrease in plasma levels of dROMs, after six months of feeding regime, in groups 2 and 4 (food supplemented with antioxidant) was observed (p < 0.005). dROMs levels remained unaltered in the first (control group) and third groups (fish-based meal, without antioxidant addition).

Bottom Line: Our results showed that a dietary regime, enriched with antioxidants, induced a significant decrease of plasma levels of dROMs (p < 0.005) and a significant increase in BDNF serum levels (p < 0.005) after six months.Thus, we hypothesized a possible role of the diet in modulating pro- and antioxidant species as well as BDNF levels in plasma and serum, respectively.In conclusion the proposed diet enriched with antioxidants might be considered a valid alternative and a valuable strategy to counteract aging-related cognitive decline in elderly dogs.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via Vienna 2, 07100 Sassari, Italy.

ABSTRACT
Biological aging is characterized by a progressive accumulation of oxidative damage and decreased endogenous antioxidant defense mechanisms. The production of oxidants by normal metabolism damages proteins, lipids, and nucleotides, which may contribute to cognitive impairment. In this study 36 dogs were randomly divided into four groups and fed croquettes of different compositions for 6 months. We monitored derivatives of reactive oxygen metabolites (dROMs) and biological antioxidant potential (BAP) levels in dogs' plasma samples as well as brain-derived neurotrophic factor (BDNF) serum levels at the beginning and at the end of the dietary regime. Our results showed that a dietary regime, enriched with antioxidants, induced a significant decrease of plasma levels of dROMs (p < 0.005) and a significant increase in BDNF serum levels (p < 0.005) after six months. Thus, we hypothesized a possible role of the diet in modulating pro- and antioxidant species as well as BDNF levels in plasma and serum, respectively. In conclusion the proposed diet enriched with antioxidants might be considered a valid alternative and a valuable strategy to counteract aging-related cognitive decline in elderly dogs.

No MeSH data available.


Related in: MedlinePlus