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Influence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4(+) CD4(+) Lymphocytes in Dogs with Atopic Dermatitis: Open Study.

Fujimura M, Ishimaru H - J Vet Med (2014)

Bottom Line: The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01).By comparison, the use of HCA on group II did not show decrease in postcortisol levels.There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence.

View Article: PubMed Central - PubMed

Affiliation: Fujimura Animal Allergy Hospital, Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan.

ABSTRACT
This study investigated the influence of 0.00584% hydrocortisone aceponate spray (HCA; Cortavance Virbac SA, Carros, France) on blood serum cortisol levels and peripheral blood CCR4(+) CD4(+) T-lymphocyte levels in dogs with atopic dermatitis. Patients were randomly divided into group I (N = 8) and group II (N = 8). The dogs in group I were sprayed with HCA on the affected skin once a day for three weeks. The dogs in group II were treated once a day for 3 days followed by no treatment for 4 days for a total of three weeks. For the dogs in group I and group II the CADESI-03 scores before and after use of HCA showed significant reduction (P < 0.01). The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01). By comparison, the use of HCA on group II did not show decrease in postcortisol levels. There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence. In addition, there was no influence on peripheral blood CCR4(+) CD4(+) lymphocytes percentage in dogs in group I after treatment with HCA.

No MeSH data available.


Related in: MedlinePlus

Three weeks use of HCA spray on dogs with CAD, CCR4+CD4+ lymphocytes percentage before and after use of HCA spray for 21 days, before (day 0) CCR4+CD4+ mean ± SD; 37.8 ± 10.8% and after (day 21) CCR4+CD4+ mean ± SD; 39.6 ± 14.4%. Statistically no significant difference was found (P > 0.05), Crossbar; <28.7 cut-off value.
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Related In: Results  -  Collection


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fig4: Three weeks use of HCA spray on dogs with CAD, CCR4+CD4+ lymphocytes percentage before and after use of HCA spray for 21 days, before (day 0) CCR4+CD4+ mean ± SD; 37.8 ± 10.8% and after (day 21) CCR4+CD4+ mean ± SD; 39.6 ± 14.4%. Statistically no significant difference was found (P > 0.05), Crossbar; <28.7 cut-off value.

Mentions: In group I, the mean and SD of CCR4+ CD4+ lymphocytes percentage before the use of HCA was 37.8 ± 10.8%. After the use of the spray the percentage was 39.6 ± 14.4%, Figure 4. CCR4+ CD4+ lymphocytes percentage did not fall below 28.7%, a cut-off level [15]. The CCR4+ CD4+ lymphocytes percentage before and after use of HCA did not show significant difference (P > 0.05).


Influence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4(+) CD4(+) Lymphocytes in Dogs with Atopic Dermatitis: Open Study.

Fujimura M, Ishimaru H - J Vet Med (2014)

Three weeks use of HCA spray on dogs with CAD, CCR4+CD4+ lymphocytes percentage before and after use of HCA spray for 21 days, before (day 0) CCR4+CD4+ mean ± SD; 37.8 ± 10.8% and after (day 21) CCR4+CD4+ mean ± SD; 39.6 ± 14.4%. Statistically no significant difference was found (P > 0.05), Crossbar; <28.7 cut-off value.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590839&req=5

fig4: Three weeks use of HCA spray on dogs with CAD, CCR4+CD4+ lymphocytes percentage before and after use of HCA spray for 21 days, before (day 0) CCR4+CD4+ mean ± SD; 37.8 ± 10.8% and after (day 21) CCR4+CD4+ mean ± SD; 39.6 ± 14.4%. Statistically no significant difference was found (P > 0.05), Crossbar; <28.7 cut-off value.
Mentions: In group I, the mean and SD of CCR4+ CD4+ lymphocytes percentage before the use of HCA was 37.8 ± 10.8%. After the use of the spray the percentage was 39.6 ± 14.4%, Figure 4. CCR4+ CD4+ lymphocytes percentage did not fall below 28.7%, a cut-off level [15]. The CCR4+ CD4+ lymphocytes percentage before and after use of HCA did not show significant difference (P > 0.05).

Bottom Line: The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01).By comparison, the use of HCA on group II did not show decrease in postcortisol levels.There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence.

View Article: PubMed Central - PubMed

Affiliation: Fujimura Animal Allergy Hospital, Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan.

ABSTRACT
This study investigated the influence of 0.00584% hydrocortisone aceponate spray (HCA; Cortavance Virbac SA, Carros, France) on blood serum cortisol levels and peripheral blood CCR4(+) CD4(+) T-lymphocyte levels in dogs with atopic dermatitis. Patients were randomly divided into group I (N = 8) and group II (N = 8). The dogs in group I were sprayed with HCA on the affected skin once a day for three weeks. The dogs in group II were treated once a day for 3 days followed by no treatment for 4 days for a total of three weeks. For the dogs in group I and group II the CADESI-03 scores before and after use of HCA showed significant reduction (P < 0.01). The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01). By comparison, the use of HCA on group II did not show decrease in postcortisol levels. There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence. In addition, there was no influence on peripheral blood CCR4(+) CD4(+) lymphocytes percentage in dogs in group I after treatment with HCA.

No MeSH data available.


Related in: MedlinePlus