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Influence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4(+) CD4(+) Lymphocytes in Dogs with Atopic Dermatitis: Open Study.

Fujimura M, Ishimaru H - J Vet Med (2014)

Bottom Line: The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01).By comparison, the use of HCA on group II did not show decrease in postcortisol levels.There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence.

View Article: PubMed Central - PubMed

Affiliation: Fujimura Animal Allergy Hospital, Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan.

ABSTRACT
This study investigated the influence of 0.00584% hydrocortisone aceponate spray (HCA; Cortavance Virbac SA, Carros, France) on blood serum cortisol levels and peripheral blood CCR4(+) CD4(+) T-lymphocyte levels in dogs with atopic dermatitis. Patients were randomly divided into group I (N = 8) and group II (N = 8). The dogs in group I were sprayed with HCA on the affected skin once a day for three weeks. The dogs in group II were treated once a day for 3 days followed by no treatment for 4 days for a total of three weeks. For the dogs in group I and group II the CADESI-03 scores before and after use of HCA showed significant reduction (P < 0.01). The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01). By comparison, the use of HCA on group II did not show decrease in postcortisol levels. There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence. In addition, there was no influence on peripheral blood CCR4(+) CD4(+) lymphocytes percentage in dogs in group I after treatment with HCA.

No MeSH data available.


Related in: MedlinePlus

Group I (n = 8), cortisol level pre-ACTH and post-ACTH after use of HCA spray for 21 days, pre-ACTH cortisol level mean ± SD; 1.4 ± 1.2 μg/dL and post-ACTH cortisol level mean ± SD; 8.9 ± 3.6 μg/dL.
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fig2: Group I (n = 8), cortisol level pre-ACTH and post-ACTH after use of HCA spray for 21 days, pre-ACTH cortisol level mean ± SD; 1.4 ± 1.2 μg/dL and post-ACTH cortisol level mean ± SD; 8.9 ± 3.6 μg/dL.

Mentions: In group I, prior to the use of HCA, the mean and SD of the cortisol levels were 3.7 ± 2.4 μg/dL (standard range 1.0–7.7 μg/dL) pre-ACTH and 13.9 ± 4.3 μg/dL (standard range 1.0–18.0 μg/dL) post-ACTH, Figure 1. The mean and SD of cortisol levels after use of HCA were 1.4 ± 1.2 μg/dL pre-ACTH and 8.9 ± 3.6 μg/dL post-ACTH, Figure 2.


Influence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4(+) CD4(+) Lymphocytes in Dogs with Atopic Dermatitis: Open Study.

Fujimura M, Ishimaru H - J Vet Med (2014)

Group I (n = 8), cortisol level pre-ACTH and post-ACTH after use of HCA spray for 21 days, pre-ACTH cortisol level mean ± SD; 1.4 ± 1.2 μg/dL and post-ACTH cortisol level mean ± SD; 8.9 ± 3.6 μg/dL.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590839&req=5

fig2: Group I (n = 8), cortisol level pre-ACTH and post-ACTH after use of HCA spray for 21 days, pre-ACTH cortisol level mean ± SD; 1.4 ± 1.2 μg/dL and post-ACTH cortisol level mean ± SD; 8.9 ± 3.6 μg/dL.
Mentions: In group I, prior to the use of HCA, the mean and SD of the cortisol levels were 3.7 ± 2.4 μg/dL (standard range 1.0–7.7 μg/dL) pre-ACTH and 13.9 ± 4.3 μg/dL (standard range 1.0–18.0 μg/dL) post-ACTH, Figure 1. The mean and SD of cortisol levels after use of HCA were 1.4 ± 1.2 μg/dL pre-ACTH and 8.9 ± 3.6 μg/dL post-ACTH, Figure 2.

Bottom Line: The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01).By comparison, the use of HCA on group II did not show decrease in postcortisol levels.There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence.

View Article: PubMed Central - PubMed

Affiliation: Fujimura Animal Allergy Hospital, Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan.

ABSTRACT
This study investigated the influence of 0.00584% hydrocortisone aceponate spray (HCA; Cortavance Virbac SA, Carros, France) on blood serum cortisol levels and peripheral blood CCR4(+) CD4(+) T-lymphocyte levels in dogs with atopic dermatitis. Patients were randomly divided into group I (N = 8) and group II (N = 8). The dogs in group I were sprayed with HCA on the affected skin once a day for three weeks. The dogs in group II were treated once a day for 3 days followed by no treatment for 4 days for a total of three weeks. For the dogs in group I and group II the CADESI-03 scores before and after use of HCA showed significant reduction (P < 0.01). The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (P < 0.01). By comparison, the use of HCA on group II did not show decrease in postcortisol levels. There was a tendency of suppression for hypothalamus-pituitary gland-adrenal gland system, but it was not serious influence. In addition, there was no influence on peripheral blood CCR4(+) CD4(+) lymphocytes percentage in dogs in group I after treatment with HCA.

No MeSH data available.


Related in: MedlinePlus