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Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique.

Pawar HA, Joshi PR - J Pharm (Cairo) (2014)

Bottom Line: The drug to stearic acid ratio 1 : 2 was found to be optimum on the basis of taste evaluation and in vitro release.The formulated granules were found to possess good flow property.The in vitro release of drug from granules was compared with marketed tablet formulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Quality Assurance, Dr. L. H. Hiranandani College of Pharmacy, Smt. CHM Campus, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra 421003, India.

ABSTRACT
Drugs from nitroimidazole category are generally bitter in taste. Oral formulation with bitter taste is not palatable. Geriatrics and pediatrics patients usually suffer from swallowing difficulties. Many other patients in some disease conditions avoid swallowing tablets. Satranidazole is a new nitro-imidazole derivative with bitter taste and is available in market as film coated tablet. The purpose of this research was to mask the bitter taste of Satranidazole by coating complexation with low melting point wax and Eudragit EPO. Different types of wax (glyceryl monostearate, stearic acid and cetyl alcohol) were tried for taste masking. The drug to stearic acid ratio 1 : 2 was found to be optimum on the basis of taste evaluation and in vitro release. The formulated granules were found to possess good flow property. FTIR studies confirmed that there was no interaction between drug and excipients. Scanning Electron Microscopy of drug and the optimized batch of granules was performed. The in vitro release of drug from granules was compared with marketed tablet formulation. The taste masked granules of optimized batch showed 87.65% release of drug in 1 hr which is comparable to that of marketed tablet formulation.

No MeSH data available.


Related in: MedlinePlus

UV spectrum of STZ in methanol.
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fig1: UV spectrum of STZ in methanol.

Mentions: The UV spectrum of STZ in methanol is shown in Figure 1. The λ max of Satranidazole sample was found to be 320 nm. STZ exhibited characteristic peaks at 1687, 1743, 1066, 1537, and 1215 cm−1 attributed to C=N stretching, C=O stretching, S=O stretching, C–NO2 stretching, and C–N vibrations. FTIR spectra showed all the important peaks of drug in spectra of drug-excipient mixture and formulation. FTIR of STZ, physical mixture of STZ with Eudragit EPO and stearic acid, and the optimized formulation is represented in Figures 2, 3, 4, and 5, respectively.


Development and Evaluation of Taste Masked Granular Formulation of Satranidazole by Melt Granulation Technique.

Pawar HA, Joshi PR - J Pharm (Cairo) (2014)

UV spectrum of STZ in methanol.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4590832&req=5

fig1: UV spectrum of STZ in methanol.
Mentions: The UV spectrum of STZ in methanol is shown in Figure 1. The λ max of Satranidazole sample was found to be 320 nm. STZ exhibited characteristic peaks at 1687, 1743, 1066, 1537, and 1215 cm−1 attributed to C=N stretching, C=O stretching, S=O stretching, C–NO2 stretching, and C–N vibrations. FTIR spectra showed all the important peaks of drug in spectra of drug-excipient mixture and formulation. FTIR of STZ, physical mixture of STZ with Eudragit EPO and stearic acid, and the optimized formulation is represented in Figures 2, 3, 4, and 5, respectively.

Bottom Line: The drug to stearic acid ratio 1 : 2 was found to be optimum on the basis of taste evaluation and in vitro release.The formulated granules were found to possess good flow property.The in vitro release of drug from granules was compared with marketed tablet formulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Quality Assurance, Dr. L. H. Hiranandani College of Pharmacy, Smt. CHM Campus, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra 421003, India.

ABSTRACT
Drugs from nitroimidazole category are generally bitter in taste. Oral formulation with bitter taste is not palatable. Geriatrics and pediatrics patients usually suffer from swallowing difficulties. Many other patients in some disease conditions avoid swallowing tablets. Satranidazole is a new nitro-imidazole derivative with bitter taste and is available in market as film coated tablet. The purpose of this research was to mask the bitter taste of Satranidazole by coating complexation with low melting point wax and Eudragit EPO. Different types of wax (glyceryl monostearate, stearic acid and cetyl alcohol) were tried for taste masking. The drug to stearic acid ratio 1 : 2 was found to be optimum on the basis of taste evaluation and in vitro release. The formulated granules were found to possess good flow property. FTIR studies confirmed that there was no interaction between drug and excipients. Scanning Electron Microscopy of drug and the optimized batch of granules was performed. The in vitro release of drug from granules was compared with marketed tablet formulation. The taste masked granules of optimized batch showed 87.65% release of drug in 1 hr which is comparable to that of marketed tablet formulation.

No MeSH data available.


Related in: MedlinePlus